Kevin C Klatt, PhD, RD
@kcklatt.bsky.social
Incoming Assistant Prof, @uoftnutrisci.bsky.social . #Metabolism Researcher, #Dietitian.
Associate Editor, American Journal of Clinical Nutrition. 🎙️Host, 'AJCN In Press' 🎙️
By way of: UC Berkeley, Baylor CoM, NIH, Cornell
Kcklatt.substack.com
Associate Editor, American Journal of Clinical Nutrition. 🎙️Host, 'AJCN In Press' 🎙️
By way of: UC Berkeley, Baylor CoM, NIH, Cornell
Kcklatt.substack.com
Pinned
This year's Annual Review of Nutrition is out and full of really great reads.
My contribution details the broad history of nutritional guidance in America & covers the forces (science/politics/culture) that have driven the evolution of nutrition guidance.
www.annualreviews.org/content/jour...
My contribution details the broad history of nutritional guidance in America & covers the forces (science/politics/culture) that have driven the evolution of nutrition guidance.
www.annualreviews.org/content/jour...
It's so grating to continue to watch COVID contrarians put forth the need to improve metabolic health. There's no serious efforts to use policy to improve dietary patterns, coverage of dietitian & exercise physio services; no attempt to regulate food systems so the default choice = healthier choice
Oh look, it’s NIH Director Jay Bhattacharya and sidecar passenger Matthew Memoli blaming individuals for dying during the pandemic, because in their view, they were lazy and ate shitty foods.
There’s a lot more to hate in this article, but that’s the (anti)appetizer.
There’s a lot more to hate in this article, but that’s the (anti)appetizer.
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org
November 16, 2025 at 12:49 AM
It's so grating to continue to watch COVID contrarians put forth the need to improve metabolic health. There's no serious efforts to use policy to improve dietary patterns, coverage of dietitian & exercise physio services; no attempt to regulate food systems so the default choice = healthier choice
New CDC update on infant botulism - 2 new cases since Nov 8th, reported presence of bacteria in an open canister of ByHeart formula from California, and a re all of ByHeart Whole Nutrition Infant Formula for all lots.
share.google/FoBGPHIxF7Q5...
share.google/FoBGPHIxF7Q5...
Investigation Update: Infant Botulism Outbreak, November 2025
Investigation details for an outbreak of infant botulism linked to infant formula, November 2025.
share.google
November 12, 2025 at 12:46 AM
New CDC update on infant botulism - 2 new cases since Nov 8th, reported presence of bacteria in an open canister of ByHeart formula from California, and a re all of ByHeart Whole Nutrition Infant Formula for all lots.
share.google/FoBGPHIxF7Q5...
share.google/FoBGPHIxF7Q5...
Glad to see more test-to-treat dosing trials happening for nutrients. Single dose vs placebo paradigms with no consideration of baseline and achieved levels have resulted in largely null but nearly uninterpretable results.
newsroom.heart.org/news/heart-a...
newsroom.heart.org/news/heart-a...
Heart attack risk halved in adults with heart disease taking tailored vitamin D doses
Research Highlights: Adults with heart disease prescribed vitamin D in doses tailored to reach blood levels considered optimal for heart health (>40-80 ng/mL) had a reduced risk of heart attack by mor...
newsroom.heart.org
November 11, 2025 at 6:35 PM
Glad to see more test-to-treat dosing trials happening for nutrients. Single dose vs placebo paradigms with no consideration of baseline and achieved levels have resulted in largely null but nearly uninterpretable results.
newsroom.heart.org/news/heart-a...
newsroom.heart.org/news/heart-a...
Continuing to see so much blatantly anti-vaccine messaging nowadays that looks no different than foodie messaging (embraced by many legit folks) from a decade ago. If your nutrition messaging can be co-opted into an anti-vaccine tropes w minimal rewording, consider changing your nutrition messaging
November 2, 2025 at 2:32 PM
Continuing to see so much blatantly anti-vaccine messaging nowadays that looks no different than foodie messaging (embraced by many legit folks) from a decade ago. If your nutrition messaging can be co-opted into an anti-vaccine tropes w minimal rewording, consider changing your nutrition messaging
Reposted by Kevin C Klatt, PhD, RD
Credit to MDPI for retracting this vitamin D/COVID-19 meta-analysis that @gidmk.bsky.social and I flagged: pubpeer.com/publications...
PubPeer - Protective Effect of Vitamin D Supplementation on COVID-19-R...
There are comments on PubPeer for publication: Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis a...
pubpeer.com
October 31, 2025 at 5:00 PM
Credit to MDPI for retracting this vitamin D/COVID-19 meta-analysis that @gidmk.bsky.social and I flagged: pubpeer.com/publications...
Reposted by Kevin C Klatt, PhD, RD
There are ongoing claims that acetaminophen (Tylenol) use in pregnancy causes autism. Here’s five things you should know 🧵
October 27, 2025 at 1:05 AM
There are ongoing claims that acetaminophen (Tylenol) use in pregnancy causes autism. Here’s five things you should know 🧵
The academic debates arnd saturated fat have largely questioned whether they're as 'bad' as once thought, given the limited association w CVD in cohort studies assessing self reported intakes in relation to risk (despite controlled feeding trials clearly showing a linear relationship w LDL/ApoB).
October 26, 2025 at 4:58 PM
The academic debates arnd saturated fat have largely questioned whether they're as 'bad' as once thought, given the limited association w CVD in cohort studies assessing self reported intakes in relation to risk (despite controlled feeding trials clearly showing a linear relationship w LDL/ApoB).
Reposted by Kevin C Klatt, PhD, RD
You may have read that your protein supplements are giving you lead poisoning. That's not the case. If you want to have protein shakes, that's fine. But whether you need to and whether they're safely regulated is a different story. My latest for @vox.com.
www.vox.com/future-perfe...
www.vox.com/future-perfe...
No, your protein powder isn’t poisoning you
New testing finds two-thirds of popular protein powders exceed lead limits — especially plant-based brands. What you need to know before your next scoop — and why the reality is different.
www.vox.com
October 22, 2025 at 2:36 PM
You may have read that your protein supplements are giving you lead poisoning. That's not the case. If you want to have protein shakes, that's fine. But whether you need to and whether they're safely regulated is a different story. My latest for @vox.com.
www.vox.com/future-perfe...
www.vox.com/future-perfe...
Reposted by Kevin C Klatt, PhD, RD
Meet Richard Frye, whose research record on leucovorin traces the gulf between promise and proof.
By Brendan Borrell
www.thetransmitter.org/spectrum/exc...
By Brendan Borrell
www.thetransmitter.org/spectrum/exc...
Exclusive: Meet Richard Frye, who studies leucovorin for autism
Frye has led two placebo-controlled trials of the folate supplement in autistic people; the first was suspended by regulators, and the other has yet to be published.
www.thetransmitter.org
October 1, 2025 at 9:29 PM
Meet Richard Frye, whose research record on leucovorin traces the gulf between promise and proof.
By Brendan Borrell
www.thetransmitter.org/spectrum/exc...
By Brendan Borrell
www.thetransmitter.org/spectrum/exc...
Folks following the leucovorin & autism story should be aware of a ton of PubPeer activity on one of the major trials. Many inconsistencies, statistical concerns, etc raised.
pubpeer.com/publications...
pubpeer.com/publications...
PubPeer - Efficacy of oral folinic acid supplementation in children wi...
There are comments on PubPeer for publication: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial (2024)
pubpeer.com
October 16, 2025 at 5:00 PM
Folks following the leucovorin & autism story should be aware of a ton of PubPeer activity on one of the major trials. Many inconsistencies, statistical concerns, etc raised.
pubpeer.com/publications...
pubpeer.com/publications...
A good insider view of a dysfunctional FDA, helping to explain why Makary said leucovorin would treat 100Ks of kids w autism, meanwhile they pursued an indication for the rare disease of CFD.
FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.
FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.
Employees inside the FDA and outside experts said they were worried the U.S. is headed toward a new era of drug regulation: one where political decisions lead, and evidence follows
www.statnews.com/2025/10/14/f...
www.statnews.com/2025/10/14/f...
Inside FDA, career staffers describe how political pressure is influencing their work
Current and former FDA staff said the level of involvement of political officials in nitty-gritty regulatory matters is unprecedented.
www.statnews.com
October 15, 2025 at 12:53 AM
A good insider view of a dysfunctional FDA, helping to explain why Makary said leucovorin would treat 100Ks of kids w autism, meanwhile they pursued an indication for the rare disease of CFD.
FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.
FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.
MMWR stole the show in the first round of headlines about CDC cuts but in the chaos, many missed that the NHANES mobile team remains RIF'd. This is the backbone of this key survey that contains some of the only representative anthropometric, biochemical, clinical and dietary data on the country.
Protecting the nation’s public health demands data, whether it be new measles cases, a surge in ER visits, or shifting patterns in obesity. The most recent job cuts at the CDC threaten the mostly unseen foundation of that research enterprise.
www.statnews.com/2025/10/14/c...
www.statnews.com/2025/10/14/c...
CDC team running top survey on health and nutrition is laid off
NHANES has collected data on eating patterns, diabetes and other common diseases for decades. The CDC team that runs it has been fired.
www.statnews.com
October 14, 2025 at 4:29 PM
MMWR stole the show in the first round of headlines about CDC cuts but in the chaos, many missed that the NHANES mobile team remains RIF'd. This is the backbone of this key survey that contains some of the only representative anthropometric, biochemical, clinical and dietary data on the country.
This moment -- when we have a failing traditional healthcare system + increasing acceptance of low evidence, hyperbolic 'food is medicine'/lifestyle/functional medicine' + a government eager to co-opt/endorse wellness slop -- is particularly scary for folks who care abt evidence-based nutrition
October 12, 2025 at 7:43 PM
This moment -- when we have a failing traditional healthcare system + increasing acceptance of low evidence, hyperbolic 'food is medicine'/lifestyle/functional medicine' + a government eager to co-opt/endorse wellness slop -- is particularly scary for folks who care abt evidence-based nutrition
Reposted by Kevin C Klatt, PhD, RD
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
October 11, 2025 at 2:10 AM
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Gave some quotes to NPR about the coming chaos with the DGAs.
Full primer here:
kcklatt.substack.com/p/what-to-ex...
Full primer here:
kcklatt.substack.com/p/what-to-ex...
October 9, 2025 at 10:16 PM
Gave some quotes to NPR about the coming chaos with the DGAs.
Full primer here:
kcklatt.substack.com/p/what-to-ex...
Full primer here:
kcklatt.substack.com/p/what-to-ex...
Peer Review reports went live on the 'Harvard' citation the administration is using to support the Tylenol-Autism/ADHD link. Pretty eyebrow raising
ehjournal.biomedcentral.com/articles/10....
ehjournal.biomedcentral.com/articles/10....
Environmental Health
Established in 2002, Environmental Health has an international readership and is rated in the top 25% of journals in this field. It covers primarily original ...
ehjournal.biomedcentral.com
September 30, 2025 at 6:10 PM
Peer Review reports went live on the 'Harvard' citation the administration is using to support the Tylenol-Autism/ADHD link. Pretty eyebrow raising
ehjournal.biomedcentral.com/articles/10....
ehjournal.biomedcentral.com/articles/10....
Nancy Mace on Bill Maher telling pregnant women to take Ibuprofen instead of Tylenol is so emblematic of everything wrong with this administrations approach to health.
September 30, 2025 at 4:11 PM
Nancy Mace on Bill Maher telling pregnant women to take Ibuprofen instead of Tylenol is so emblematic of everything wrong with this administrations approach to health.
Reposted by Kevin C Klatt, PhD, RD
It was a pleasure to chat with @drjessicaknurick.bsky.social about ultra-processed foods and other topics discussed in my new book Food Intelligence co-authored with @juliabelluz.bsky.social.
substack.com/home/post/p-...
substack.com/home/post/p-...
Ultraprocessed Foods with Dr. Kevin Hall
Few scientists have shaped the way we understand nutrition and metabolism as much as Dr.
substack.com
September 30, 2025 at 1:16 PM
It was a pleasure to chat with @drjessicaknurick.bsky.social about ultra-processed foods and other topics discussed in my new book Food Intelligence co-authored with @juliabelluz.bsky.social.
substack.com/home/post/p-...
substack.com/home/post/p-...
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
September 28, 2025 at 12:25 AM
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
Every basic scientist & PhD program director should be watching how cell culture and rodent models of Tylenol exposure are being used by motivated parties (e.g. it depletes your glutathione! Science proves it PMID...) to sell a narrative and sow confusion right now.
September 26, 2025 at 11:32 PM
Every basic scientist & PhD program director should be watching how cell culture and rodent models of Tylenol exposure are being used by motivated parties (e.g. it depletes your glutathione! Science proves it PMID...) to sell a narrative and sow confusion right now.
Really excited to announce that I've accepted an Assistant Professor position in the Department of Nutritional Sciences in the Faculty of Medicine at the University of Toronto! Looking forward to venturing north (🥶) & building out my own research group focused on human nutrition & metabolism 🥳
Big news! Thrilled to welcome Dr. Kevin Klatt as our newest Assistant Professor in Nutritional Sciences! From Cornell → NIH → Baylor → UC Berkeley, he brings expertise in maternal & infant nutrition + micronutrients! Join us in welcoming him! @kcklatt.bsky.social @uoftmedicine.bsky.social
September 24, 2025 at 12:23 AM
Really excited to announce that I've accepted an Assistant Professor position in the Department of Nutritional Sciences in the Faculty of Medicine at the University of Toronto! Looking forward to venturing north (🥶) & building out my own research group focused on human nutrition & metabolism 🥳
Excited to listen to the new nutrition science book from @kevinh-phd.bsky.social & @juliabelluz.bsky.social !
It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science.
amzn.to/42akyvM
It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science.
amzn.to/42akyvM
September 23, 2025 at 3:57 PM
Excited to listen to the new nutrition science book from @kevinh-phd.bsky.social & @juliabelluz.bsky.social !
It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science.
amzn.to/42akyvM
It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science.
amzn.to/42akyvM
It's very bizarre that the admin pursued a leucovorin indication for children with cerebral folate deficiency and autism symptoms, not for general autism. CFD is rare and the diagnosis is confirmed by measuring folate levels in cerebrospinal fluid, which most general cases of autism won't have.
September 23, 2025 at 3:58 AM
It's very bizarre that the admin pursued a leucovorin indication for children with cerebral folate deficiency and autism symptoms, not for general autism. CFD is rare and the diagnosis is confirmed by measuring folate levels in cerebrospinal fluid, which most general cases of autism won't have.
For an admin that loves to weaponize the quality of the science behind COVID pandemic public health restrictions and emphasizes needing gold standard science, it's interesting we are inflating the risks of Tylenol & benefits of Leucovorin based on pretty weak evidence
September 22, 2025 at 11:17 PM
For an admin that loves to weaponize the quality of the science behind COVID pandemic public health restrictions and emphasizes needing gold standard science, it's interesting we are inflating the risks of Tylenol & benefits of Leucovorin based on pretty weak evidence
The hilariously butchered pronouncement of acetaminophen makes me really wish someone had tried to call leucovorin by its chemical name, 5-formyltetrahydrofolate
September 22, 2025 at 11:09 PM
The hilariously butchered pronouncement of acetaminophen makes me really wish someone had tried to call leucovorin by its chemical name, 5-formyltetrahydrofolate