Kazuhiro Maeshima
@kazu-maeshima.bsky.social
#Chromatin biologist/biophysicist @NIG & SOKENDAI in Japan.
Chromatin is very dynamic and flexible, but NOT regular!!! 🧪🧬🔬
My career and work: http://bit.ly/2CuF4L5
Lab HP: https://bit.ly/3F1a8nk
YouTube Seminar: https://bit.ly/4fYZiOj
Chromatin is very dynamic and flexible, but NOT regular!!! 🧪🧬🔬
My career and work: http://bit.ly/2CuF4L5
Lab HP: https://bit.ly/3F1a8nk
YouTube Seminar: https://bit.ly/4fYZiOj
Thanks. Yes, we agree to your point.
September 11, 2025 at 11:21 PM
Thanks. Yes, we agree to your point.
Thanks @zeinabrekad.bsky.social for your kind words. We totally agree to your point, and indeed we are working on H1:
bsky.app/profile/kazu...
www.biorxiv.org/content/10.1...
bsky.app/profile/kazu...
www.biorxiv.org/content/10.1...
September 11, 2025 at 11:20 PM
Thanks @zeinabrekad.bsky.social for your kind words. We totally agree to your point, and indeed we are working on H1:
bsky.app/profile/kazu...
www.biorxiv.org/content/10.1...
bsky.app/profile/kazu...
www.biorxiv.org/content/10.1...
Reposted by Kazuhiro Maeshima
Condensed chromatin domain structure and cohesin-constrained mobility assure independent transcription regulation for each domain!
Also consistent with many previous studies.
(4/n)
Also consistent with many previous studies.
(4/n)
August 29, 2025 at 10:57 AM
Condensed chromatin domain structure and cohesin-constrained mobility assure independent transcription regulation for each domain!
Also consistent with many previous studies.
(4/n)
Also consistent with many previous studies.
(4/n)
Thank you so much!
August 29, 2025 at 10:43 AM
Thank you so much!
Thank you for the nice list. Could you add me to the list?
August 29, 2025 at 8:03 AM
Thank you for the nice list. Could you add me to the list?
🧩 Also highly relevant: a modeling study from Bin Zhang group predicts condensed euchromatin domains with active protrusions. Perfectly complementary to our findings! 3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 28, 2025 at 4:18 AM
🧩 Also highly relevant: a modeling study from Bin Zhang group predicts condensed euchromatin domains with active protrusions. Perfectly complementary to our findings! 3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We thank all the coauthors: @katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san @lschermelleh.bsky.social, Toyoda-san. 🙏Special thanks to @healthcare.nikon.com for 3D-SIM support. Also see our related paper@TICB bit.ly/4fW4cfL 2
Is euchromatin really open in the cell?
Growing evidence has demonstrated that strings of nucleosomes, consisting of DNA wrapped
around core histones [1], are rather irregularly and dynamically folded as chromatin
in the cell (Figure 1A,B) ...
bit.ly
August 28, 2025 at 4:18 AM
We thank all the coauthors: @katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san @lschermelleh.bsky.social, Toyoda-san. 🙏Special thanks to @healthcare.nikon.com for 3D-SIM support. Also see our related paper@TICB bit.ly/4fW4cfL 2