Katsuhiko Minami
@katsuminami.bsky.social
Postdoc at Maeshima-Lab (@kazu-maeshima.bsky.social), National Institute of Genetics, Japan / Interested in chromatin, replication, microscopy, ...
Reposted by Katsuhiko Minami
🧩 Also highly relevant: a modeling study from Bin Zhang group predicts condensed euchromatin domains with active protrusions. Perfectly complementary to our findings! 3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 28, 2025 at 4:18 AM
🧩 Also highly relevant: a modeling study from Bin Zhang group predicts condensed euchromatin domains with active protrusions. Perfectly complementary to our findings! 3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Katsuhiko Minami
We thank all the coauthors: @katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san @lschermelleh.bsky.social, Toyoda-san. 🙏Special thanks to @healthcare.nikon.com for 3D-SIM support. Also see our related paper@TICB bit.ly/4fW4cfL 2
Is euchromatin really open in the cell?
Growing evidence has demonstrated that strings of nucleosomes, consisting of DNA wrapped
around core histones [1], are rather irregularly and dynamically folded as chromatin
in the cell (Figure 1A,B) ...
bit.ly
August 28, 2025 at 4:18 AM
We thank all the coauthors: @katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san @lschermelleh.bsky.social, Toyoda-san. 🙏Special thanks to @healthcare.nikon.com for 3D-SIM support. Also see our related paper@TICB bit.ly/4fW4cfL 2
Reposted by Katsuhiko Minami
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
🔬 Original paper: www.science.org/doi/full/10....
🔬 Original paper: www.science.org/doi/full/10....
Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells
Local chromatin motion remains steady during interphase, allowing cells to conduct housekeeping tasks under similar environments.
www.science.org
April 25, 2025 at 12:24 AM
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
🔬 Original paper: www.science.org/doi/full/10....
🔬 Original paper: www.science.org/doi/full/10....
(2/2) Deepest thanks to Maeshima-sensei (@kazu-maeshima.bsky.social), all the collaborators of this paper, and Maeshima-Lab members. Proud to have been involved in this wonderful work!
April 1, 2025 at 12:11 PM
(2/2) Deepest thanks to Maeshima-sensei (@kazu-maeshima.bsky.social), all the collaborators of this paper, and Maeshima-Lab members. Proud to have been involved in this wonderful work!
Reposted by Katsuhiko Minami
We quantitatively measured nucleosome motion across the 4 chromatin classes, from euchromatin to heterochromatin.
🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion.
🎉 Congrats @katsuminami.bsky.social @kakonakazato.bsky.social and all collaborators!
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🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion.
🎉 Congrats @katsuminami.bsky.social @kakonakazato.bsky.social and all collaborators!
2/2
March 29, 2025 at 1:06 AM
We quantitatively measured nucleosome motion across the 4 chromatin classes, from euchromatin to heterochromatin.
🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion.
🎉 Congrats @katsuminami.bsky.social @kakonakazato.bsky.social and all collaborators!
2/2
🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion.
🎉 Congrats @katsuminami.bsky.social @kakonakazato.bsky.social and all collaborators!
2/2