Before a job interview 😅

First time it happened to my lecture I thought it's an earthquake (Greek in Switzerland)

#RNASky #BiologySky #CryoEM

This work was possible thanks with the Cryo-EM hub at the @ethz.ch and the BSF screening facility at the EPFL.
@nccr-rna-disease.bsky.social @mcid-unibe.bsky.social

🧬 NT-2 binds at 60S PTC where peptide bonds form and stabilizes an inactive SERBP1-bound state only when living cells are treated,
establishing a direct structural link between a small-molecule inhibitor and ribosome dormancy.
#translation #cryoEM #biochemistry

💡 We built a quantitative human-based cell-free translation platform that tests thousands of reactions in parallel, directly measuring protein synthesis while bypassing cellular toxicity.

#quantitativebiology #RNA #ribosome #cellfree #drugdiscovery

Very exciting and nicely illustrated! Congratulations!

Thanks a lot, Jonathan!