🧬 NT-2 binds at 60S PTC where peptide bonds form and stabilizes an inactive SERBP1-bound state only when living cells are treated,
establishing a direct structural link between a small-molecule inhibitor and ribosome dormancy.
#translation #cryoEM #biochemistry

💡 We built a quantitative human-based cell-free translation platform that tests thousands of reactions in parallel, directly measuring protein synthesis while bypassing cellular toxicity.

#quantitativebiology #RNA #ribosome #cellfree #drugdiscovery

Excellent science, impeccable organisation and breathtaking views in and out the #RNA turnover #BiochemEvent in Brighton, UK 🌊🧬 @biochemsoc.bsky.social

🌊 Potential lab logo 🌊

What if I told you, there is a way to pause the time?

Our method paper to produce efficient cell-free translation lysates from diverse human cell types is out 🎉 www.jbc.org/article/S002... @unibe.ch @mcid-unibe.bsky.social
@muehlemann.bsky.social @nickkouvelas.bsky.social

Winning the lecturer of the year award from the #Biology department of @unibe.ch definitely made my day 🤩🎉 (after a tough week, otherwise 😅). UniBern has been very supportive and generous in providing excellent teaching courses so KUDOS to them!

Lessons on how to breathe 🌳🇨🇭
#Biochemistry #academicteaching @unibe.ch

I think I study more #Biochemistry on semester weekends than my students 😅
Gluconeogenesis feat. Greek language lessons 🍭

Kandersteg has been the hub for the swiss @nccr-rna-disease.bsky.social RNA for most of the last 9 years of workshops. Collaborations and friendships were made, posters were drugged on ice streets, and plans and dreams were made on frozen slopes. Those #RNA days in Kandersteg have left their mark.

The very informative 2023-2024 #RNA review series in @embojournal.bsky.social has been completed. Throwback to our contribution, reviewing how #coronaviruses modulate host cell translation 🔬🦠
www.embopress.org/page/journal...
www.embopress.org/doi/full/10....

New pre-print 📢:Cell-free translation from diverse human cell types: Fast, reproducible and scalable
t.co/IAld0ocjDf
@nickkouvelas.bsky.social @unibern.bsky.social #biorxiv #mRNA #Ribosome