KaiTanLab
@kaitanlab.bsky.social
Kai Tan lab at Children's Hospital of Philadelphia and University of Pennsylvania
Reposted by KaiTanLab
1/3 Excited to share our latest preprint: TissueCraftAI! 🚀
It's the FIRST 1B-parameter spatial omics model built on ControlNet & Stable Diffusion. 🧬🤖
Moving beyond CNNs, it enables query-driven prediction of molecular maps directly from histology.
🔗 www.biorxiv.org/content/10.6...
It's the FIRST 1B-parameter spatial omics model built on ControlNet & Stable Diffusion. 🧬🤖
Moving beyond CNNs, it enables query-driven prediction of molecular maps directly from histology.
🔗 www.biorxiv.org/content/10.6...
Query-driven generative AI synthesizes multi-modal spatial omics from histology
Spatial omics technologies offer unprecedented insights into the cellular organization of tissues; however, they are not yet scalable for routine clinical use. In contrast, images of histological stai...
www.biorxiv.org
December 15, 2025 at 7:33 PM
1/3 Excited to share our latest preprint: TissueCraftAI! 🚀
It's the FIRST 1B-parameter spatial omics model built on ControlNet & Stable Diffusion. 🧬🤖
Moving beyond CNNs, it enables query-driven prediction of molecular maps directly from histology.
🔗 www.biorxiv.org/content/10.6...
It's the FIRST 1B-parameter spatial omics model built on ControlNet & Stable Diffusion. 🧬🤖
Moving beyond CNNs, it enables query-driven prediction of molecular maps directly from histology.
🔗 www.biorxiv.org/content/10.6...
Chill out at annual lab outing on a nice cool September day. We had much of the state park to ourselves now the summer crowd is pretty much gone.
September 18, 2025 at 10:17 PM
Chill out at annual lab outing on a nice cool September day. We had much of the state park to ourselves now the summer crowd is pretty much gone.
Reposted by KaiTanLab
Check out this fantastic plenary paper from @katanlab.bsky.social and colleagues in @bloodjournal.bsky.social: tinyurl.com/mr9nzj3k
Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2
Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2
June 7, 2025 at 6:31 PM
Check out this fantastic plenary paper from @katanlab.bsky.social and colleagues in @bloodjournal.bsky.social: tinyurl.com/mr9nzj3k
Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2
Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2
In our new paper in Nature Genetics www.nature.com/articles/s41... we identified a novel ERBB4 signaling axis between macrophages and neuroblasts in therapy resistance in high risk neuroblastoma.
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring - Nature Genetics
Analysis of pre- and post-chemotherapy samples collected from 22 patients with high-risk neuroblastoma using single-nucleus RNA and ATAC sequencing and spatial omics characterizes therapy-related chan...
www.nature.com
May 9, 2025 at 12:48 PM
In our new paper in Nature Genetics www.nature.com/articles/s41... we identified a novel ERBB4 signaling axis between macrophages and neuroblasts in therapy resistance in high risk neuroblastoma.
In four recent papers, we and colleagues characterized HSPC-like blast heterogeneity across pediatric ALLs, and revealed several molecular mechanisms for their roles in leukemogenesis and therapy resistance. tinyurl.com/573ncj98, tinyurl.com/27f95scn, tinyurl.com/fb25akcn, tinyurl.com/mwjvncvk.
March 22, 2025 at 2:05 PM
In four recent papers, we and colleagues characterized HSPC-like blast heterogeneity across pediatric ALLs, and revealed several molecular mechanisms for their roles in leukemogenesis and therapy resistance. tinyurl.com/573ncj98, tinyurl.com/27f95scn, tinyurl.com/fb25akcn, tinyurl.com/mwjvncvk.
Congratulations to the newly minted Dr. Jonathan Sussman! Job well done. We are all very pround of your achievement.
March 22, 2025 at 1:43 PM
Congratulations to the newly minted Dr. Jonathan Sussman! Job well done. We are all very pround of your achievement.
Excited to share our latest work in @NatureCancer to get a better understanding why relapsed T-ALL is so deadly and potential target strategies, led by Jason Xu and @changya1 with members of David Teachey, @junjyang, @CMullighan and many great colleagues.
twtr.to/foS9o
twtr.to/foS9o
March 18, 2025 at 1:08 AM
Excited to share our latest work in @NatureCancer to get a better understanding why relapsed T-ALL is so deadly and potential target strategies, led by Jason Xu and @changya1 with members of David Teachey, @junjyang, @CMullighan and many great colleagues.
twtr.to/foS9o
twtr.to/foS9o
Happy to share our newest work, CelloType, to improve segmentation and annotation of tissue spatial omics data.CelloType performs simultaneous segmentation and structure annotation using a transformer-based model.
twtr.to/T0m76
twtr.to/T0m76
March 18, 2025 at 1:08 AM
Happy to share our newest work, CelloType, to improve segmentation and annotation of tissue spatial omics data.CelloType performs simultaneous segmentation and structure annotation using a transformer-based model.
twtr.to/T0m76
twtr.to/T0m76
It's that time of the year... Lab outing 2024!
March 18, 2025 at 1:08 AM
It's that time of the year... Lab outing 2024!
Excited to share the first spatially resolved multiomics atlas for human bone marrow, published today in @CellCellPress.Wonderful collaborations with Ling Qin @LingQin6, Charles Nelson, Martin Carroll, Ivan Maillard, Vinohd Pillai @pillai_vinodh labs!
twtr.to/cJ099
twtr.to/cJ099
March 18, 2025 at 1:08 AM
Excited to share the first spatially resolved multiomics atlas for human bone marrow, published today in @CellCellPress.Wonderful collaborations with Ling Qin @LingQin6, Charles Nelson, Martin Carroll, Ivan Maillard, Vinohd Pillai @pillai_vinodh labs!
twtr.to/cJ099
twtr.to/cJ099
Interested in understanding tissue cellular architecture changes in disease and development with spatial omics data? check out our new method, CytoCommunity published in @naturemethods,
twtr.to/AfDEQ twtr.to/Gyefw
twtr.to/AfDEQ twtr.to/Gyefw
March 18, 2025 at 1:08 AM
Interested in understanding tissue cellular architecture changes in disease and development with spatial omics data? check out our new method, CytoCommunity published in @naturemethods,
twtr.to/AfDEQ twtr.to/Gyefw
twtr.to/AfDEQ twtr.to/Gyefw
Another bittersweet moment to send off Changya Chen @Changya1, a brilliant former postdoc, lab member and friend. Changya will continue his great science in his own lab at the Chinese Academy of Medical Sciences and Peking Union Medical College this Spring.
March 18, 2025 at 1:07 AM
Another bittersweet moment to send off Changya Chen @Changya1, a brilliant former postdoc, lab member and friend. Changya will continue his great science in his own lab at the Chinese Academy of Medical Sciences and Peking Union Medical College this Spring.
Happy holidays from the Tan lab! Wish you a peaceful and productive 2024!
March 18, 2025 at 1:07 AM
Happy holidays from the Tan lab! Wish you a peaceful and productive 2024!
Congratulations to a lab alum, Greg Chen, for being recognized in the Forbes 30 Under 30 list. We are incredibly proud of his achievement.
forbes.com/profile/gregor…
forbes.com/profile/gregor…
Gregory Chen
Gregory Chen on the 2024 30 Under 30 - Science - Gregory Chen's research focuses on CAR-T cell therapy, a groundbreaking approach to genetically modify
www.forbes.com
March 18, 2025 at 1:07 AM
Congratulations to a lab alum, Greg Chen, for being recognized in the Forbes 30 Under 30 list. We are incredibly proud of his achievement.
forbes.com/profile/gregor…
forbes.com/profile/gregor…
It is bittersweet to send off Yang Ding @YangDing19, a brilliant physician scientist, lab member and friend. Yang will continue her great science and patient care in her own lab at John Hopkins School of Medicine this Fall.
March 18, 2025 at 1:07 AM
It is bittersweet to send off Yang Ding @YangDing19, a brilliant physician scientist, lab member and friend. Yang will continue her great science and patient care in her own lab at John Hopkins School of Medicine this Fall.
Congratulations to the newly minted Dr. Shovik Bandyopadhyay! Job well done. We are all very pround of your achievement.
March 18, 2025 at 1:07 AM
Congratulations to the newly minted Dr. Shovik Bandyopadhyay! Job well done. We are all very pround of your achievement.
As it draws to a close, we would like to highlight our group of summer interns at @CHOP_Research and @PennMedEVDCSO, Arianne Parvaresh-Rizi, Liya Mooradian, Harley Hernandez, Barera Ajaz. You are such a talent and dynamic quad! Thank you @_hubmap:
hubmapconsortium.org/internship-pro…
hubmapconsortium.org/internship-pro…
March 18, 2025 at 1:07 AM
As it draws to a close, we would like to highlight our group of summer interns at @CHOP_Research and @PennMedEVDCSO, Arianne Parvaresh-Rizi, Liya Mooradian, Harley Hernandez, Barera Ajaz. You are such a talent and dynamic quad! Thank you @_hubmap:
hubmapconsortium.org/internship-pro…
hubmapconsortium.org/internship-pro…
After some much needed calories and H2O, everyone is happy again.
March 18, 2025 at 1:07 AM
After some much needed calories and H2O, everyone is happy again.
Some friendly competition under hot summer sun! And the winner of egg toss is 🥁...
March 18, 2025 at 1:07 AM
Some friendly competition under hot summer sun! And the winner of egg toss is 🥁...
It's that time of the year... Lab outing 2023!
March 18, 2025 at 1:07 AM
It's that time of the year... Lab outing 2023!
Congrats to Jason Xu for successful defense of his PhD thesis! Absolutely amazing body of work on the discovery and targeting of treatment resistant subpopulations in T-cell ALL . We are very proud of your achievement and looking forward to seeing your amazing work in the future!
March 18, 2025 at 1:07 AM
Congrats to Jason Xu for successful defense of his PhD thesis! Absolutely amazing body of work on the discovery and targeting of treatment resistant subpopulations in T-cell ALL . We are very proud of your achievement and looking forward to seeing your amazing work in the future!
We are excited to welcome Susan Kelley as our lab manager!
March 18, 2025 at 1:07 AM
We are excited to welcome Susan Kelley as our lab manager!
Happy holidays from the Tan lab!
March 18, 2025 at 1:06 AM
Happy holidays from the Tan lab!
Congratulations to Wenbao Yu for winning the Inaugural Klaus Hummeler High-Impact Publication Awards by CHOP research institute! Here's their awesome paper:
tinyurl.com/2p8k7w23
tinyurl.com/2p8k7w23
Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia | Blood | American Society of Hematology
Abstract. KMT2A-rearranged (KMT2A-r) infant ALL is a devastating malignancy with a dismal outcome, and younger age at diagnosis is associated with increase
tinyurl.com
March 18, 2025 at 1:06 AM
Congratulations to Wenbao Yu for winning the Inaugural Klaus Hummeler High-Impact Publication Awards by CHOP research institute! Here's their awesome paper:
tinyurl.com/2p8k7w23
tinyurl.com/2p8k7w23
