🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

It’s always a bit awkward to write about personal experiences. I tried to touch on what Pride means to me and ended up reflecting on heteronormativity, passing, and allyship. Thank you @slefkopoulos.bsky.social for the great opportunity! @ucph.bsky.social
#LGBTQIA+ #PRIDE #Diversity

There is still some time to secure your spot at the next Niche meeting in CPH. We have a great lineup of speakers! @novo-nordisk.bsky.social sciencecluster.dk/event/confer...

I could not have been more proud! The first student from the lab just defended his PhD in great style!! Congratulations Arnau Casòliba Melich !!! A huge thank you to the committee @bernasozen.bsky.social Ana Boskovic and @aramariaceleste.bsky.social

It was fun to chat with @amjeve.bsky.social about my fantastic mentors and how it is to become independent at reNEW_Global @ucph.bsky.social

💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL

In a new preprint with @trabelink.bsky.social, T. Moritz & @bonalditiziana.bsky.social, we find that implantation leads to rewiring of the TCA cycle to support histone acetylation turnover and exit from naïve pluripotency. Gr8 work of @elenikafkia.bsky.social D. Pladevall-Morera et al. rb.gy/clk8vm

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j
@natcellbio.nature.com

Become Our New Faculty Colleague! We are looking for a junior Principal Investigator to expand their stem cell research towards translational outcomes.
reNEW Copenhagen @ucph.bsky.social
#stemcell #diversity #faculty #regenerativemedicine shorturl.at/m9Zko

It was very fun to contribute to this article: "But genes are not the whole story. New research has shown the extent to which cell metabolism (...) has an important, underappreciated role in directing cell fates". www.quantamagazine.org/how-metaboli... QuantaMagazine @ucph.bsky.social

Only 2 weeks left to apply! 16 fantastic positions available, also @ucph.bsky.social . For our project remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

I’m very excited about this collaborative project! We managed to significantly scale up and streamline human blastoid generation without the use of feeders. @leeboratory.bsky.social @grazianomartello.bsky.social @pasquelab.bsky.social and Nicolas Rivron @ucph.bsky.social