Merci également @ugsf-lille.bsky.social pour cette collaboration fructueuse!

www.nature.com/articles/s43...

7/7 This work was made possible thanks to the support of @ImpetusGrants, @AgenceRecherche.bsky.social, @CNRSbiologie.bsky.social, @CNRS_DR20, @Inserm.bsky.social, @insermpacacorse, @univ-cotedazur, #AgeMed_Inserm, @IHU-RespirERA.bsky.social, @Institut_cancer and @CancerpolePACA. Thank you so much!!

6/7 We are deeply grateful to Professor Eric Gilson for his unfailing support from the very beginning of this adventure. His advice has been crucial in making this project what it is today.

5/7 A huge thank you to all collaborators that contributes to this work at @ircaninstitute and beyond (@CRCL_Lyon, @MC_Michallet, @LP2M_Lab, @IPMC_Sophia, IRMB, @C3M_U1065, @umr8576, TIRO_lab) for their invaluable contributions.

4/7 By targeting GD3 with immunotherapy in mice, we demonstrated reduced fibrosis (lung, liver) and osteoporosis. These findings open exciting therapeutic avenues for combating aging and its associated diseases.

3/7 SICs are a novel mechanism that allows senescent cells to escape immune clearance by NK cells. GD3 acts as an "invisibility cloak," enabling these cells to persist, to be “tolerated” by immune system and contribute to age-related diseases.

2/7 Huge congratulations to @IltisCharlene and @IrynaMoskaleva.bsky.social, the incredible co-first authors of this work. You worked so hard for this! Nice present for Christmas!