Jules Michalska
@julesmichalska.bsky.social
Optical Connectomics Scientist at E11 Bio.
All things light microscopy, brain architecture & connectomics 🧠🔬🐈⬛
All things light microscopy, brain architecture & connectomics 🧠🔬🐈⬛
Helloooo all, I will be at SfN this year and would love to chat! Please come by, and reach out!!!
The E11 Bio team is headed to Society for Neuroscience #Sfn2025! Come talk circuit mapping, protein barcodes, expansion microscopy, and optical connectomics at our booth (#4015) and posters!
More info: e11.bio/sfn
Ask us about our reception!
More info: e11.bio/sfn
Ask us about our reception!
November 14, 2025 at 6:10 PM
Helloooo all, I will be at SfN this year and would love to chat! Please come by, and reach out!!!
Reposted by Jules Michalska
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
October 1, 2025 at 2:16 PM
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
Reposted by Jules Michalska
We're excited to welcome Jeff Chen and JinYoung Lee to the team! 🎉
Both are University of Toronto undergrads joining us for a gap year. Jeff will work on barcode design and viral payloads, while JinYoung will focus on expansion microscopy and imaging.
Both are University of Toronto undergrads joining us for a gap year. Jeff will work on barcode design and viral payloads, while JinYoung will focus on expansion microscopy and imaging.
June 10, 2025 at 4:49 PM
We're excited to welcome Jeff Chen and JinYoung Lee to the team! 🎉
Both are University of Toronto undergrads joining us for a gap year. Jeff will work on barcode design and viral payloads, while JinYoung will focus on expansion microscopy and imaging.
Both are University of Toronto undergrads joining us for a gap year. Jeff will work on barcode design and viral payloads, while JinYoung will focus on expansion microscopy and imaging.
Reposted by Jules Michalska
"Academic research groups and startups are essential drivers of scientific progress. But some projects, like the Hubble Space Telescope or the Human Genome Project, are too big for any one academic lab or loose consortium..."
Former MIT researchers advance a new model for innovation
Developed by former MIT researchers, focused research organizations (FROs) undertake large research efforts and have begun to contribute to scientific advances.
news.mit.edu
June 9, 2025 at 7:46 PM
"Academic research groups and startups are essential drivers of scientific progress. But some projects, like the Hubble Space Telescope or the Human Genome Project, are too big for any one academic lab or loose consortium..."
Reposted by Jules Michalska
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
May 29, 2025 at 3:29 PM
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Reposted by Jules Michalska
I'm really hoping to see some applications of PlantEx this year — tell your plant friends! 🍀
If you are a plant biologist yourself and interested, skeptical, or struggling implementing expansion microscopy — just write me; it's easy & I'd love to be of assistance! 🌺
www.biorxiv.org/content/10.1...
If you are a plant biologist yourself and interested, skeptical, or struggling implementing expansion microscopy — just write me; it's easy & I'd love to be of assistance! 🌺
www.biorxiv.org/content/10.1...
February 16, 2025 at 2:26 AM
I'm really hoping to see some applications of PlantEx this year — tell your plant friends! 🍀
If you are a plant biologist yourself and interested, skeptical, or struggling implementing expansion microscopy — just write me; it's easy & I'd love to be of assistance! 🌺
www.biorxiv.org/content/10.1...
If you are a plant biologist yourself and interested, skeptical, or struggling implementing expansion microscopy — just write me; it's easy & I'd love to be of assistance! 🌺
www.biorxiv.org/content/10.1...
Our work at @e11bio.bsky.social in connectomics is featured in @asimovpress.bsky.social ! We’re building new tools to map the brain with greater precision and scale.
Can we treat brain disorders by restoring neural connections?
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
February 10, 2025 at 6:16 PM
Our work at @e11bio.bsky.social in connectomics is featured in @asimovpress.bsky.social ! We’re building new tools to map the brain with greater precision and scale.
Reposted by Jules Michalska
Do you work with confocal, STED or MINFLUX microscopes, commercial or homebuilt? Do you struggle with control of your spatial light modulator or with incorporating adaptive optics, or do you just need more flexibility? Have a look at my SLM control code:
github.com/wiebkejahr/s...
github.com/wiebkejahr/s...
GitHub - wiebkejahr/slm_control
Contribute to wiebkejahr/slm_control development by creating an account on GitHub.
github.com
January 20, 2025 at 8:38 PM
Do you work with confocal, STED or MINFLUX microscopes, commercial or homebuilt? Do you struggle with control of your spatial light modulator or with incorporating adaptive optics, or do you just need more flexibility? Have a look at my SLM control code:
github.com/wiebkejahr/s...
github.com/wiebkejahr/s...
Reposted by Jules Michalska
#microscopy #preprint alert!
The manuscript shows how to correct sample drifts. In 3D, with nm precision, not requiring more hardware than a widefield arm!
Congrats @JakobVorlaufer 🥳
I wrote the SLM control software used for aligning the control beams 🤓
www.biorxiv.org/content/10.1...
The manuscript shows how to correct sample drifts. In 3D, with nm precision, not requiring more hardware than a widefield arm!
Congrats @JakobVorlaufer 🥳
I wrote the SLM control software used for aligning the control beams 🤓
www.biorxiv.org/content/10.1...
Image-based 3D active sample stabilization on the nanometer scale for optical microscopy
Super-resolution microscopy often entails long acquisition times of minutes to hours. Since drifts during the acquisition adversely affect data quality, active sample stabilization is commonly used fo...
www.biorxiv.org
January 15, 2025 at 2:04 PM
#microscopy #preprint alert!
The manuscript shows how to correct sample drifts. In 3D, with nm precision, not requiring more hardware than a widefield arm!
Congrats @JakobVorlaufer 🥳
I wrote the SLM control software used for aligning the control beams 🤓
www.biorxiv.org/content/10.1...
The manuscript shows how to correct sample drifts. In 3D, with nm precision, not requiring more hardware than a widefield arm!
Congrats @JakobVorlaufer 🥳
I wrote the SLM control software used for aligning the control beams 🤓
www.biorxiv.org/content/10.1...
Reposted by Jules Michalska
🔬peeps!
I am delighted to finally publish my code for controlling a spatial light modulator (SLM) to perform adaptive optics & to sculpt the vortex beams for STED & MINFLUX microscopy - complete w graphical user interface for easy use!
github.com/wiebkejahr/s...
Short user manual🧵
I am delighted to finally publish my code for controlling a spatial light modulator (SLM) to perform adaptive optics & to sculpt the vortex beams for STED & MINFLUX microscopy - complete w graphical user interface for easy use!
github.com/wiebkejahr/s...
Short user manual🧵
January 15, 2025 at 3:31 PM
🔬peeps!
I am delighted to finally publish my code for controlling a spatial light modulator (SLM) to perform adaptive optics & to sculpt the vortex beams for STED & MINFLUX microscopy - complete w graphical user interface for easy use!
github.com/wiebkejahr/s...
Short user manual🧵
I am delighted to finally publish my code for controlling a spatial light modulator (SLM) to perform adaptive optics & to sculpt the vortex beams for STED & MINFLUX microscopy - complete w graphical user interface for easy use!
github.com/wiebkejahr/s...
Short user manual🧵
Here at E11BIO we have been working hard to make optical #connectomics accessible for the scientific community. Check out our journey!
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 6, 2024 at 6:57 PM
Here at E11BIO we have been working hard to make optical #connectomics accessible for the scientific community. Check out our journey!