Jolanda van Leeuwen
jsvanleeuwen.bsky.social
Jolanda van Leeuwen
@jsvanleeuwen.bsky.social
Associate Professor | Functional Genomics | UMass Chan Medical School
Reposted by Jolanda van Leeuwen
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26

genetics-gsa.org/yeast-2026/
November 7, 2025 at 3:41 PM
Reposted by Jolanda van Leeuwen
Join a collaborative home of Nobel Prize-winning biomedical research. Advance discoveries of the treatment and prevention of diseases. The Morningside Graduate School of Biomedical Sciences is accepting applications for the Biomedical Sciences PhD program: direc.to/nEHU

#PhD #PhDSky
November 4, 2025 at 4:33 PM
Reposted by Jolanda van Leeuwen
I’m excited to highlight our latest paper, just published in Cell 🎉

We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.

1/n 🧪

www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...
www.cell.com
August 15, 2025 at 6:35 PM
Reposted by Jolanda van Leeuwen
The May issue of #G3journal features work by Paltenghi and @jsvanleeuwen.bsky.social which identifies highly conserved genetic suppression mechanisms across genetically diverse yeast isolates in an effort to reduce disease severity in genetic disorders.

Read more: buff.ly/AhEqx0f
May 22, 2025 at 6:03 PM
The latest work of PhD student Claire Paltenghi
@fbm-unil.bsky.social @unil.bsky.social @umasschan.bsky.social, on the conservation of genetic suppression interactions across genetic contexts, now published in G3 @genetics-gsa.bsky.social: doi.org/10.1093/g3jo...
Genetic suppression interactions are highly conserved across genetically diverse yeast isolates
Sometimes the detrimental effects of a mutation can be rescued by another mutation. For genetic diseases, such suppressor mutations may identify new therap
doi.org
May 9, 2025 at 11:52 AM
Reposted by Jolanda van Leeuwen
<grumble> funding agencies, scoring schemes on “clarity of hypothesis” is quite a straightjacket. There is plenty of v good discovery/ hypothesis generating science which doesn’t have a “narrow” hypothesis
May 5, 2025 at 9:05 AM
Reposted by Jolanda van Leeuwen
For those of you interested in cancer synthetic lethality, this should be a v interesting Gordon Conference organised by @mgarnett.bsky.social @vazquezf.bsky.social & Benjamin Schwartz- highly recommended ! www.grc.org/synthetic-le...
2025 Synthetic Lethality Approaches in Oncology Conference GRC
The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
March 20, 2025 at 1:32 PM
Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1...

So what did we find?
The modifiers that cause changes in gene essentiality
www.biorxiv.org
March 9, 2025 at 2:45 PM
Reposted by Jolanda van Leeuwen
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
January 31, 2025 at 1:49 PM
Reposted by Jolanda van Leeuwen
Yeast Genetics & Genomics at CSHL
July 22 - August 12, 2025

Application Deadline: March 31, 2025
Arrival: July 22nd by 6pm EST
Departure: August 12th around 12pm EST

For more info and to apply please visit the Yeast Genetics & Genomics course website: meetings.cshl.edu/courses.aspx...
January 17, 2025 at 2:57 PM
Reposted by Jolanda van Leeuwen
📢 #Yeast2025 News!
Registration and abstract submission are NOW OPEN!
Join us at the 32nd ICYGMB
📅 Save the Date: 21-24 July 2025
📍 Location: Paris @sorbonne-universite.fr
🔗 Submit: premc.org/yeast2025/su...
🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...
January 14, 2025 at 7:28 AM
Come join us at CSHL in March for the Network Biology meeting! Less than two weeks left to submit your abstract
January 14, 2025 at 8:38 PM
Reposted by Jolanda van Leeuwen
Hey #networkbiology bubble and affinionados. Don't miss the CSHL Meeting: Network Biology in spring 2025. Great panel of speakers lined up by the organizers @fritzroth.bsky.social @pedrobeltrao.bsky.social, Roded Sharan, and @jsvanleeuwen.bsky.social.

meetings.cshl.edu/meetings.asp...
Network Biology
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
December 5, 2024 at 9:14 PM
Reposted by Jolanda van Leeuwen
Calling all systems and computational biologists in search of a faculty position:

We have Assistant and Associate Professor positions! 🚀

Pittsburgh is beautiful, and we are doing amazing science here.

cfopitt.taleo.net/careersectio...

cfopitt.taleo.net/careersectio...

Please apply by Dec 2!
Faculty.Professor.Assistant - Full-Time
Click the link provided to see the complete job description.
cfopitt.taleo.net
November 20, 2024 at 1:58 PM