Raúl Valderrama
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jrmarval.bsky.social
Raúl Valderrama
@jrmarval.bsky.social
Experimental Biologist.
Bioinformatician in process.
RNAseq & TME BrCa.
National Autonomous University of Mexico &
Cancer and Virology Research Unit, Children's Hospital of Mexico Federico Gomez.
We are the tool's documentation (which no one reads), a YouTube tutorial by an Asian guy (who explains it better than the actual paper), ChatGPT (which sometimes makes things up but keeps my morale high), and my stubbornness, against my expert thesis committee… clearly, it's a fair fight 🫠
March 26, 2025 at 5:27 PM
Hundreds of cancer papers mention cell lines that don’t seem to exist | Science | AAAS www.science.org/content/arti...
Hundreds of cancer papers mention cell lines that don’t seem to exist
Finding could be an indicator of paper mill activity
www.science.org
February 11, 2025 at 11:00 PM
🧬 Spatial transcriptomics is revolutionizing biology! It maps gene expression in 3D, revealing how cells interact in tissues.
🦠 From tumor progression to immune responses, this tech unlocks key insights into health and disease. 🚀 #Science #SpatialTranscriptomics

www.csbj.org/article/S200...
A guidebook of spatial transcriptomic technologies, data resources and analysis approaches
Advances in transcriptomic technologies have deepened our understanding of the cellular gene expression programs of multicellular organisms and provided a theoretical basis for disease diagnosis and t...
www.csbj.org
February 3, 2025 at 8:40 PM

scRNA-seq analyzes gene expression at the single-cell level, uncovering cellular heterogeneity. It identifies biomarkers, reconstructs cellular trajectories, and enables personalized therapies, revolutionizing precision medicine.

www.nature.com/articles/s41...
Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data - Nature Protocols
In this Tutorial Review, Hemberg et al. present an overview of the computational workflow involved in processing single-cell RNA sequencing data.
www.nature.com
January 27, 2025 at 9:05 AM
Reposted by Raúl Valderrama
More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers

https://go.nature.com/3Ej9R
xA
More than 40% of postdocs leave academia, study reveals
Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
go.nature.com
January 26, 2025 at 10:39 AM
Reposted by Raúl Valderrama
The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences

https://go.nature.com/3PNuEfh
Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences
Bidirectional transfer of mitochondria between cancer and immune cells.
go.nature.com
January 24, 2025 at 3:53 PM
Reposted by Raúl Valderrama
A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases

https://go.nature.com/3POiHpJ
A scalable system using mini-organs to test personalized RNA therapy
Platform to accelerate the testing of antisense oligonucleotides.
go.nature.com
January 25, 2025 at 12:06 PM