jormahaarala.bsky.social
@jormahaarala.bsky.social
Retired researcher interested in drug development and natural sciences
Reposted
J Med Chem is on 🔥 with the editorials lately, and I highly recommend giving this one a read. Understanding free drug principles is the gateway to all of pharmacology, and is all too often mangled and misapplied by drug discovery practitioners.
Free Drug Concepts: A Lingering Problem in Drug Discovery
pubs.acs.org
March 22, 2025 at 2:54 PM
www.nature.com/articles/s41... Approximately half the energy of CO2 capture needed compared to leading direct air capture technologies.
Thermal Ca2+/Mg2+ exchange reactions to synthesize CO2 removal materials - Nature
Reactions of Mg-rich silicates with calcium carbonates/sulfates result in the formation of materials that could potentially be used for low-cost carbon dioxide removal from the atmosphere.
www.nature.com
March 10, 2025 at 6:56 AM
Reposted
Over 100 kids sick, many hospitalized, 1 dead, and the outbreak is continuing to spread. Measles vaccine is a safe and effective medicine that could've prevented this if parents had used it. Sad apnews.com/article/meas...
An unvaccinated child has died in the Texas measles outbreak
A child who was not vaccinated has died from measles in West Texas. It's the first death in an outbreak that began late last month and the first from measles in the U.S. since 2015.
apnews.com
February 26, 2025 at 5:09 PM
Anticancer activity of RAPTA-EA1 in triple-negative BRCA1 proficient breast cancer cells: single and combined treatment with the PARP inhibitor olaparib: Heliyon www.cell.com/heliyon/full...
Anticancer activity of RAPTA-EA1 in triple-negative BRCA1 proficient breast cancer cells: single and combined treatment with the PARP inhibitor olaparib
Anti-cancer drugs; Metal-based drugs; BRCA1; RAPTA-EA1; Olaparib.
www.cell.com
February 18, 2025 at 6:51 AM
Reposted
clever idea, once pursued by Xios, we worried about potential autoimmune toxicities however
January 14, 2025 at 2:08 PM
Scientists peel away the mystery of JAK enzymes, which play roles in everything from eczema to ulcerative colitis medicalxpress.com/news/2025-02... via @medical_xpress
Scientists peel away the mystery of JAK enzymes, which play roles in everything from eczema to ulcerative colitis
Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of medications called JAK inhibitors, using an acronym that assumes the averag...
medicalxpress.com
February 8, 2025 at 3:07 PM
Weakness in lung cancer's defenses found—an enzyme that boosts cancer cell metabolism medicalxpress.com/news/2025-02... via @medical_xpress
Weakness in lung cancer's defenses found—an enzyme that boosts cancer cell metabolism
Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment.
medicalxpress.com
February 8, 2025 at 2:44 PM
Due to the low water solubility of tolvaptan, the developed
plant-derived nanovesicles like
tolvaptan or liposome/tolvaptan nanoparticle complexes may present a novel and effective strategy for nanodrug delivery.
www.sciencedirect.com/science/arti...
February 2, 2025 at 5:55 PM
Reposted
Are you using the Chemical Probes Portal? If not, it’s time to explore this FREE resource which offers expert advice on >800 chemical probes, along with detailed guidelines on:
✅ How to choose the best probe for your protein of interest.
✅ How to use it appropriately to ensure reliable results.
January 6, 2025 at 3:45 PM
Reposted
Vertex’s non-opioid pain drug gets FDA approval for acute pain. #biosky #medsky "The culmination of decades of work, Vertex’s Journavx is now cleared to treat the short-lived 'acute' pain usually felt after an accident or a surgery." www.biopharmadive.com/news/vertex-...
Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research
Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.
www.biopharmadive.com
January 30, 2025 at 11:15 PM
Reposted
Vertex wins FDA approval for non-opioid pain drug, setting stage for closely watched rollout www.statnews.com/2025/01/30/v... via @jonathanwosen.bsky.social
Vertex wins FDA approval for non-opioid pain drug, setting stage for closely watched rollout
Vertex Pharmaceuticals won FDA approval for a non-opioid drug for moderate to severe acute pain
www.statnews.com
January 30, 2025 at 11:16 PM
Reposted
Disperazol Pharma joins the AMR Industry Alliance to combat #AMR by targeting biofilms and supporting biotech innovation. Their approach enhances drug efficacy through advanced delivery methods like nanoparticles, targeted therapies, and AI-driven optimization.

karacasanime.com.ve/uncategorize...
Breakthrough Partnership: Disperazol Pharma Takes Bold Steps Against Global Antibiotic Resistance!
Breakthrough Partnership: Disperazol Pharma Takes Bold Steps Against Global Antibiotic Resistance! - Clinique Bio
karacasanime.com.ve
January 31, 2025 at 4:46 AM