New CRISPR libraries from the @johndoench.bsky.social and Root labs — Jacquere (human) and Julianna (mouse).
A perfect pairing for your next screen. 🍷🧀
https://twp.ai/9PX2kT
https://twp.ai/4irnYP

Excited to share work with
Zhidian Zhang, @milot.bsky.social, @martinsteinegger.bsky.social, and @sokrypton.org
biorxiv.org/content/10.1...
TLDR: We introduce MSA Pairformer, a 111M parameter protein language model that challenges the scaling paradigm in self-supervised protein language modeling🧵

💡 Want to investigate your target gene by mapping mutations, together with functional/genomic annotation on protein 3D structure? Discover the potential of Genomics 2 Proteins portal.

🔹 Taught by Sumaiya Iqbal & @jordansafer.bsky.social (@broadinstitute.org) at #bc2

👉Register: tinyurl.com/3y8ay2d6

Inverse folding models fine-tuned on ddG data are SOTA on stability/thermostability prediction, & can be further improved by including features from PLMs; additionally, these help identify conserved AAs whose functional importance isn't obvious from structure alone www.biorxiv.org/content/10.1...

Before you all go crazy, note that this is mixed chirality structure prediction

I have a story very similar to Emily’s. I am the longest ever patient on a Cystic Fibrosis modulator drug, currently at 15 years. I went from annual hospitalizations and to no chronic cough anymore. I wrote my will at 22 and like Francis Collins mentioned yesterday, now I have a retirement plan.