mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Republicans on spending committee push back against proposed reorganization and overhead cuts

University of Washington Human Resources

Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II+ cells at single-cell …

Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...

Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

Nature - A coordinated cellular network regulates tolerance to food

Mucosal Immunology Podcast · Episode

While debates in the U.S. rage about potential overexposure to fluoride, people worldwide still lack basic access to it.

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.

The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.