Jon Mosser
@jonmosser.com
Pediatric infectious disease doc | global health researcher | modelling disease burden and intervention coverage from local to global scales | #vaccines, #VPDs, #NTDs, #malaria, #anemia, #hemoglobinopathies, #geospatial analysis | he/him | opinions my own
Thanks to @thelancetinfdis.bsky.social for the opportunity to publish these updated estimates.
November 4, 2025 at 4:51 PM
Thanks to @thelancetinfdis.bsky.social for the opportunity to publish these updated estimates.
Author Share link for the Lancet ID paper on the global, regional, and national burden of Chagas disease (free access for the next 50 days) authors.elsevier.com/a/1m2hA5E-Uo...
Permanent link to the paper directly on the Lancet ID website: www.thelancet.com/journals/lan...
Permanent link to the paper directly on the Lancet ID website: www.thelancet.com/journals/lan...
November 4, 2025 at 3:57 PM
Author Share link for the Lancet ID paper on the global, regional, and national burden of Chagas disease (free access for the next 50 days) authors.elsevier.com/a/1m2hA5E-Uo...
Permanent link to the paper directly on the Lancet ID website: www.thelancet.com/journals/lan...
Permanent link to the paper directly on the Lancet ID website: www.thelancet.com/journals/lan...
Thank you to our multinational team of GBD 2023 Chagas Disease Collaborators, the RAISE Study, and our NTDs team at IHME for collaborating to produce this critical, updated analysis!
November 4, 2025 at 3:57 PM
Thank you to our multinational team of GBD 2023 Chagas Disease Collaborators, the RAISE Study, and our NTDs team at IHME for collaborating to produce this critical, updated analysis!
To get better estimates, we need improved data quality, including adequate coding to prevent misclassification of Chagas deaths and better estimates of the true population at risk. Sustained funding for screening, treatment, and improved data collection is crucial to mitigate #Chagas disease burden.
November 4, 2025 at 3:55 PM
To get better estimates, we need improved data quality, including adequate coding to prevent misclassification of Chagas deaths and better estimates of the true population at risk. Sustained funding for screening, treatment, and improved data collection is crucial to mitigate #Chagas disease burden.
Prevalence also shifted to older age groups, peaking at 45–65 years in 2023. This reflects decreasing incidence in endemic locations. Health systems must prepare for chronic care needs as the burden of disease shifts to older populations.
November 4, 2025 at 3:54 PM
Prevalence also shifted to older age groups, peaking at 45–65 years in 2023. This reflects decreasing incidence in endemic locations. Health systems must prepare for chronic care needs as the burden of disease shifts to older populations.
Cases in non-endemic locations increased 46.2%, primarily due to prevalence amongst people who have migrated from endemic countries. Improved awareness about #Chagas disease and systems to improve access to diagnosis & treatment for these individuals in non-endemic locations are needed.
November 4, 2025 at 3:53 PM
Cases in non-endemic locations increased 46.2%, primarily due to prevalence amongst people who have migrated from endemic countries. Improved awareness about #Chagas disease and systems to improve access to diagnosis & treatment for these individuals in non-endemic locations are needed.
We estimated 10.5 million global prevalent cases in 2023. There has been major progress: age-standardised mortality dropped by 72.5% from 1990–2023. This success reflects strong vector control and socioeconomic development in endemic regions.
#GlobalHealth #NTDs
#GlobalHealth #NTDs
November 4, 2025 at 3:51 PM
We estimated 10.5 million global prevalent cases in 2023. There has been major progress: age-standardised mortality dropped by 72.5% from 1990–2023. This success reflects strong vector control and socioeconomic development in endemic regions.
#GlobalHealth #NTDs
#GlobalHealth #NTDs
June 25, 2025 at 5:05 PM
I had the chance to speak with @npr.org before this announcement, on this critical moment for #vaccination.
"The world is going to have to pick a trajectory," [Mosser] says. "Are we going to turn our backs on one of the most remarkable public health achievements that the world has ever seen?"
"The world is going to have to pick a trajectory," [Mosser] says. "Are we going to turn our backs on one of the most remarkable public health achievements that the world has ever seen?"
The good news (154 million deaths avoided) and bad news about childhood vaccines
A new study points out success stories — and potential obstacles — to bringing vaccines to the world's children.
www.npr.org
June 25, 2025 at 5:04 PM
I had the chance to speak with @npr.org before this announcement, on this critical moment for #vaccination.
"The world is going to have to pick a trajectory," [Mosser] says. "Are we going to turn our backs on one of the most remarkable public health achievements that the world has ever seen?"
"The world is going to have to pick a trajectory," [Mosser] says. "Are we going to turn our backs on one of the most remarkable public health achievements that the world has ever seen?"
Bill Moss of @ivac-hopkins.bsky.social on the challenges to come:
"...the study’s analysis took place prior to the shifts in U.S. federal funding... “The situation is even more challenging, I think, in the coming years than is even outlined in this analysis,” Moss told STAT."
"...the study’s analysis took place prior to the shifts in U.S. federal funding... “The situation is even more challenging, I think, in the coming years than is even outlined in this analysis,” Moss told STAT."
June 25, 2025 at 4:25 PM
Bill Moss of @ivac-hopkins.bsky.social on the challenges to come:
"...the study’s analysis took place prior to the shifts in U.S. federal funding... “The situation is even more challenging, I think, in the coming years than is even outlined in this analysis,” Moss told STAT."
"...the study’s analysis took place prior to the shifts in U.S. federal funding... “The situation is even more challenging, I think, in the coming years than is even outlined in this analysis,” Moss told STAT."
We have a choice: do we turn our backs on the most successful public health intervention that the world has ever known? Or do we redouble our efforts to ensure that everyone, everywhere can benefit from the protection of lifesaving #vaccines?
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June 25, 2025 at 2:05 AM
We have a choice: do we turn our backs on the most successful public health intervention that the world has ever known? Or do we redouble our efforts to ensure that everyone, everywhere can benefit from the protection of lifesaving #vaccines?
/🧵
/🧵
In the decades to come, we need strong global leadership and support from governments and other programs. We need to ensure that national immunization programs have the resources they need to tailor vaccination programs to the needs of their communities.
June 25, 2025 at 2:03 AM
In the decades to come, we need strong global leadership and support from governments and other programs. We need to ensure that national immunization programs have the resources they need to tailor vaccination programs to the needs of their communities.
As we move into the second half of this decade, we're at a pivotal moment - coming out of the COVID pandemic, partially but not fully recovered from its impact, and on the heels of more than a decade of slowed progress in many countries. We're at a crossroads.
June 25, 2025 at 2:01 AM
As we move into the second half of this decade, we're at a pivotal moment - coming out of the COVID pandemic, partially but not fully recovered from its impact, and on the heels of more than a decade of slowed progress in many countries. We're at a crossroads.
And USAID has had a key role in monitoring vaccine coverage, particularly in LMICs, through the Demographics and Health Surveys. Just over half of all of our survey data sources in this study came from the DHS program. This data is crucial to monitor immunization and many other health metrics.
June 25, 2025 at 2:00 AM
And USAID has had a key role in monitoring vaccine coverage, particularly in LMICs, through the Demographics and Health Surveys. Just over half of all of our survey data sources in this study came from the DHS program. This data is crucial to monitor immunization and many other health metrics.
@Gavi has played a major role in supporting many countries in rolling out and scaling up new vaccines and enhancing delivery for more established vaccines, while they work towards more sustainable domestic funding approaches.
June 25, 2025 at 1:58 AM
@Gavi has played a major role in supporting many countries in rolling out and scaling up new vaccines and enhancing delivery for more established vaccines, while they work towards more sustainable domestic funding approaches.
WHO plays a key role in providing guidance, too - for instance, in developing strategies that have been crucial in mitigating the effects of the COVID-19 pandemic on essential health services like immunization.
June 25, 2025 at 1:57 AM
WHO plays a key role in providing guidance, too - for instance, in developing strategies that have been crucial in mitigating the effects of the COVID-19 pandemic on essential health services like immunization.
In our manuscript, for instance, we rely heavily on data collected by @who.int and @unicef.org, as well as the contextual information that comes from their expertise and close connections with countries.
June 25, 2025 at 1:56 AM
In our manuscript, for instance, we rely heavily on data collected by @who.int and @unicef.org, as well as the contextual information that comes from their expertise and close connections with countries.
In the paper, we point out that the progress made over the past decades has involved deep, sustained collaboration - from local to global levels - and that this needs to continue to achieve the full promise of immunization, as outlined in #IA2030.
June 25, 2025 at 1:54 AM
In the paper, we point out that the progress made over the past decades has involved deep, sustained collaboration - from local to global levels - and that this needs to continue to achieve the full promise of immunization, as outlined in #IA2030.