@jonathanrwallace.bsky.social
Reposted
Before the midterms of 1866, President Andrew Johnson called his congressional opponents traitors and said they should be hanged.
Voters were so profoundly moved by his words... that they gave his opponents a supermajority in Congress, and the nation got the Fourteenth Amendment.
Voters were so profoundly moved by his words... that they gave his opponents a supermajority in Congress, and the nation got the Fourteenth Amendment.
November 20, 2025 at 3:33 PM
Before the midterms of 1866, President Andrew Johnson called his congressional opponents traitors and said they should be hanged.
Voters were so profoundly moved by his words... that they gave his opponents a supermajority in Congress, and the nation got the Fourteenth Amendment.
Voters were so profoundly moved by his words... that they gave his opponents a supermajority in Congress, and the nation got the Fourteenth Amendment.
Reposted
Being an AI-enabled worker is essentially about letting AI do all of your work and being competent enough to review & catch its errors.
This leads to two outcomes:
1. The output gap between the best workers and the average will explode.
2. Entry-level workers are at a massive disadvantage.
This leads to two outcomes:
1. The output gap between the best workers and the average will explode.
2. Entry-level workers are at a massive disadvantage.
November 19, 2025 at 2:43 PM
Being an AI-enabled worker is essentially about letting AI do all of your work and being competent enough to review & catch its errors.
This leads to two outcomes:
1. The output gap between the best workers and the average will explode.
2. Entry-level workers are at a massive disadvantage.
This leads to two outcomes:
1. The output gap between the best workers and the average will explode.
2. Entry-level workers are at a massive disadvantage.
Reposted
Folks are asking what to do about the One Special Boy's AI vids and whether they should share them:
MOCK THEM WITHOUT SHARING.
This creates what an enthymeme, where readers have to SUPPLY PART OF THE REFERENT to understand what you are mocking. An enthymeme is the STRONGEST form of persuasion.
MOCK THEM WITHOUT SHARING.
This creates what an enthymeme, where readers have to SUPPLY PART OF THE REFERENT to understand what you are mocking. An enthymeme is the STRONGEST form of persuasion.
October 19, 2025 at 3:07 AM
Folks are asking what to do about the One Special Boy's AI vids and whether they should share them:
MOCK THEM WITHOUT SHARING.
This creates what an enthymeme, where readers have to SUPPLY PART OF THE REFERENT to understand what you are mocking. An enthymeme is the STRONGEST form of persuasion.
MOCK THEM WITHOUT SHARING.
This creates what an enthymeme, where readers have to SUPPLY PART OF THE REFERENT to understand what you are mocking. An enthymeme is the STRONGEST form of persuasion.
Reposted
Multiple times this year I’ve had coffee with fellow immigrants who grew up in corrupt third world countries and the shared sentiment has been that Americans don’t understand how bad things are going to get.
August 9, 2025 at 1:40 PM
Multiple times this year I’ve had coffee with fellow immigrants who grew up in corrupt third world countries and the shared sentiment has been that Americans don’t understand how bad things are going to get.
Reposted
The horrifying moment for me growing up was realizing that if you can put together enough layers of indirection then you can get away with murder.
Shooting someone is a crime but denying them funding for life saving food or medical care? That’s just bureaucracy.
Shooting someone is a crime but denying them funding for life saving food or medical care? That’s just bureaucracy.
The Boy Genius Who Killed 14 Million Poor People
What is the moral weight of responsibility for the men who carried out DOGE’s work?
www.thebulwark.com
August 5, 2025 at 1:50 PM
The horrifying moment for me growing up was realizing that if you can put together enough layers of indirection then you can get away with murder.
Shooting someone is a crime but denying them funding for life saving food or medical care? That’s just bureaucracy.
Shooting someone is a crime but denying them funding for life saving food or medical care? That’s just bureaucracy.
Reposted
As Trump signals he will fire or replace government officials who publish negative inflation or jobs numbers, it’s a good time to remember that the reason communism killed millions of people in China under Mao was government officials being pressured to lie about how much food they actually had.
August 1, 2025 at 6:42 PM
As Trump signals he will fire or replace government officials who publish negative inflation or jobs numbers, it’s a good time to remember that the reason communism killed millions of people in China under Mao was government officials being pressured to lie about how much food they actually had.
Reposted
OK, this is wild.
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
May 12, 2025 at 3:20 PM
OK, this is wild.
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
Reposted
These are real images of exoplanets.
Four super-Jupiters, imaged 10 times over 12 years around a star 133 lightyears away.
These are real, giant worlds, out there in the dark.
And we can see them.
Four super-Jupiters, imaged 10 times over 12 years around a star 133 lightyears away.
These are real, giant worlds, out there in the dark.
And we can see them.
May 7, 2025 at 7:57 PM
These are real images of exoplanets.
Four super-Jupiters, imaged 10 times over 12 years around a star 133 lightyears away.
These are real, giant worlds, out there in the dark.
And we can see them.
Four super-Jupiters, imaged 10 times over 12 years around a star 133 lightyears away.
These are real, giant worlds, out there in the dark.
And we can see them.
I wish I knew someone who gets this (me).
just picked this up, hopefully it’s got some good knock knock jokes inside
April 30, 2025 at 1:49 AM
I wish I knew someone who gets this (me).
Reposted
Reposted
The FBI just arrested a sitting judge.
April 25, 2025 at 2:39 PM
The FBI just arrested a sitting judge.
How many people know that contracting measles makes your body forget how it fought off previous bugs (up to 7 out of 10 bugs you can now get again)?
It is called immune amnesia.
asm.org/articles/201....
It is called immune amnesia.
asm.org/articles/201....
Measles and Immune Amnesia | ASM.org
Measles is much more serious than a rash and fever: it also causes immune amnesia and leaves patients especially vulnerable to secondary infection.
asm.org
April 25, 2025 at 2:44 PM
How many people know that contracting measles makes your body forget how it fought off previous bugs (up to 7 out of 10 bugs you can now get again)?
It is called immune amnesia.
asm.org/articles/201....
It is called immune amnesia.
asm.org/articles/201....
Reposted
Economists polled by the Wall Street Journal have significantly revised their forecasts downward for the US economy since January. The consensus went from 2-3% growth to flat or a shrinking economy.
A guaranteed recession based on one guy’s vibes and misunderstanding of trade deficits.
A guaranteed recession based on one guy’s vibes and misunderstanding of trade deficits.
April 21, 2025 at 8:21 PM
Economists polled by the Wall Street Journal have significantly revised their forecasts downward for the US economy since January. The consensus went from 2-3% growth to flat or a shrinking economy.
A guaranteed recession based on one guy’s vibes and misunderstanding of trade deficits.
A guaranteed recession based on one guy’s vibes and misunderstanding of trade deficits.
Reposted
Hard to overstate the extent to which we have handicapped our ability to deal with adversarial
abuse because “ceNsOrsHiP!” screamers have cowed people into ceasing to study, and companies into ceasing to mitigate, the most transparently manipulative things. www.washingtonpost.com/technology/2...
abuse because “ceNsOrsHiP!” screamers have cowed people into ceasing to study, and companies into ceasing to mitigate, the most transparently manipulative things. www.washingtonpost.com/technology/2...
Russia seeds chatbots with lies. Any bad actor could game AI the same way.
In their race to push out new versions with more capability, AI companies leave users vulnerable to “LLM grooming” efforts that promote bogus information.
www.washingtonpost.com
April 18, 2025 at 1:48 PM
Hard to overstate the extent to which we have handicapped our ability to deal with adversarial
abuse because “ceNsOrsHiP!” screamers have cowed people into ceasing to study, and companies into ceasing to mitigate, the most transparently manipulative things. www.washingtonpost.com/technology/2...
abuse because “ceNsOrsHiP!” screamers have cowed people into ceasing to study, and companies into ceasing to mitigate, the most transparently manipulative things. www.washingtonpost.com/technology/2...
Reposted
Today, we report the first independent study from our lab describing a new technology for live imaging and manipulation of homeostatic microglia (brain-resident macrophages) in the brain.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
GPCR-targeted imaging and manipulation of homeostatic microglia in living systems
Microglia, the resident innate immune cells of the brain, are known to perform key roles such as synaptic pruning, apoptotic debris removal, and pathogen defense in the central nervous system. Microglial mutations are directly linked to many neurodevelopmental (e.g., schizophrenia) and neurodegenerative (e.g., Alzheimer's disease) disorders, indicating the diagnostic and therapeutic potential of microglia for treating these conditions. Currently, we lack robust molecular tools to specifically image and manipulate microglia in vivo, which presents a major hurdle in our understanding of the brain-wide functions of these cells during the early onset of brain diseases. Here, we describe a molecular technology for imaging and manipulation of homeostatic microglia in live organisms (e.g., in zebrafish and mice) by covalently targeting the purinergic receptor, P2RY12. Using this technology, we imaged microglia-pathogen interactions in the larval zebrafish brain and revealed various morphological states of microglia in the adult mouse brain. We further expanded the microglia labelling approach to single-microglia tracking and microglial surfaceome mapping using photoactivatable fluorophores and photoproximity labelling, respectively. We anticipate the use of this universal tool for studying microglial biology across species to reveal the dynamics and polarization of resting microglia into a reactive state found in many neurodegenerative diseases. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
April 6, 2025 at 6:50 PM
Today, we report the first independent study from our lab describing a new technology for live imaging and manipulation of homeostatic microglia (brain-resident macrophages) in the brain.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Reposted
I regularly read Fox News headlines to see how news stories are being presented to MAGA.
This morning’s fascinating because there’s no mention of the impact of tariffs to readers or the stock market tanking.
Instead it’s directing anger at Republicans who aren’t all in on Trump tanking the economy
This morning’s fascinating because there’s no mention of the impact of tariffs to readers or the stock market tanking.
Instead it’s directing anger at Republicans who aren’t all in on Trump tanking the economy
April 3, 2025 at 2:20 PM
I regularly read Fox News headlines to see how news stories are being presented to MAGA.
This morning’s fascinating because there’s no mention of the impact of tariffs to readers or the stock market tanking.
Instead it’s directing anger at Republicans who aren’t all in on Trump tanking the economy
This morning’s fascinating because there’s no mention of the impact of tariffs to readers or the stock market tanking.
Instead it’s directing anger at Republicans who aren’t all in on Trump tanking the economy
Reposted
This is insane.
They are tearing up the fabric of society, the things we fund together so that we can thrive have a more prosperous country.
And they are going to hand the money that was going toward this to themselves.
They are tearing up the fabric of society, the things we fund together so that we can thrive have a more prosperous country.
And they are going to hand the money that was going toward this to themselves.
Everyone who works for PRAMS (the Pregnancy Risk Assessment Monitoring System) at CDC was terminated today. That appears to be the end of a critical program which monitored infant and maternal health nationwide across pregnancy, childbirth & postpartum. talkingpointsmemo.com/edblog/prams...
PRAMS Shuttered for Good
In the first weeks of the administration I wrote a number of...
talkingpointsmemo.com
April 2, 2025 at 3:10 AM
This is insane.
They are tearing up the fabric of society, the things we fund together so that we can thrive have a more prosperous country.
And they are going to hand the money that was going toward this to themselves.
They are tearing up the fabric of society, the things we fund together so that we can thrive have a more prosperous country.
And they are going to hand the money that was going toward this to themselves.
Reposted
Highly recommend. How a social media company makes decisions that affect all of us. us.macmillan.com/books/978125...
Careless People
#1 New York Times Bestseller“Careless People is darkly funny and genuinely shocking...Not only does [Sarah Wynn-Williams] have the storytelling chops to un...
us.macmillan.com
April 2, 2025 at 3:12 AM
Highly recommend. How a social media company makes decisions that affect all of us. us.macmillan.com/books/978125...
Zuckerberg and Sandberg sued to prevent this book from being promoted.
app.thestorygraph.com/books/f7e310...
app.thestorygraph.com/books/f7e310...
Careless People: A Cautionary Tale of Power, Greed, and Lost Idealism by Sarah Wynn-Williams
An explosive insider account charting one woman's career at the heart of one of the most influent...
app.thestorygraph.com
March 31, 2025 at 1:51 PM
Zuckerberg and Sandberg sued to prevent this book from being promoted.
app.thestorygraph.com/books/f7e310...
app.thestorygraph.com/books/f7e310...
Reposted
How can you ever pretend to be a serious law firm again after you have become a supplicant?
Nobody is looking to hire an advocate who prostrates themselves to a regime of clowns, just retire.
Nobody is looking to hire an advocate who prostrates themselves to a regime of clowns, just retire.
March 29, 2025 at 1:51 AM
How can you ever pretend to be a serious law firm again after you have become a supplicant?
Nobody is looking to hire an advocate who prostrates themselves to a regime of clowns, just retire.
Nobody is looking to hire an advocate who prostrates themselves to a regime of clowns, just retire.
Reposted
“Ordinary Germans” not that long ago.
berto.fyi/4iQdr1K
"Nazi perpetrators and leaders were not freaks, but they had been brought up in a culture of rancid, self-pitying national paranoia … almost all the prominent Nazis came from middle-class families with right-wing values—“
berto.fyi/3FVds5O
berto.fyi/4iQdr1K
"Nazi perpetrators and leaders were not freaks, but they had been brought up in a culture of rancid, self-pitying national paranoia … almost all the prominent Nazis came from middle-class families with right-wing values—“
berto.fyi/3FVds5O
Ordinary Germans | Neal Ascherson
We know who the Nazis were and what they did. In Hitler's People, the distinguished historian Richard J. Evans seeks to explain what what made them capable of doing it.
berto.fyi
March 28, 2025 at 11:59 AM
“Ordinary Germans” not that long ago.
berto.fyi/4iQdr1K
"Nazi perpetrators and leaders were not freaks, but they had been brought up in a culture of rancid, self-pitying national paranoia … almost all the prominent Nazis came from middle-class families with right-wing values—“
berto.fyi/3FVds5O
berto.fyi/4iQdr1K
"Nazi perpetrators and leaders were not freaks, but they had been brought up in a culture of rancid, self-pitying national paranoia … almost all the prominent Nazis came from middle-class families with right-wing values—“
berto.fyi/3FVds5O
Reposted
What Hegseth, Watlz, Gabbard, and Rubio did on purpose broke the law, not only should all of them be fired they should all be investigated and charged.
Judge orders Trump administration to preserve Signal chat about Yemen military operation. apple.news/AqG3YDXWrT9a...
Judge orders Trump administration to preserve Signal chat about Yemen military operation. apple.news/AqG3YDXWrT9a...
Judge orders Trump administration to preserve Signal chat about Yemen military operation — The Washington Post
Judge James E. Boasberg, whom has already drawn President Donald Trump’s ire, ordered national security agencies to preserve the records of a leaked group Signal chat, reportedly set to auto-delete.
apple.news
March 28, 2025 at 12:08 AM
What Hegseth, Watlz, Gabbard, and Rubio did on purpose broke the law, not only should all of them be fired they should all be investigated and charged.
Judge orders Trump administration to preserve Signal chat about Yemen military operation. apple.news/AqG3YDXWrT9a...
Judge orders Trump administration to preserve Signal chat about Yemen military operation. apple.news/AqG3YDXWrT9a...
Reposted
Conservatives like to complain about “the mainstream media” but in reality the mainstream of social media, cable news and podcasts is decidedly right wing.
It’s only legacy print media that is arguably left-wing in outlook. And barely so.
It’s only legacy print media that is arguably left-wing in outlook. And barely so.
March 27, 2025 at 7:29 PM
Conservatives like to complain about “the mainstream media” but in reality the mainstream of social media, cable news and podcasts is decidedly right wing.
It’s only legacy print media that is arguably left-wing in outlook. And barely so.
It’s only legacy print media that is arguably left-wing in outlook. And barely so.