"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."

@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇

theconversation.com/the-science-...

#obesity #metabolism

@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’

Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social

Read it here: www.cell.com/cell/fulltex...

The brain is the master regulator of food intake and energy balance. A brilliant new @cellpress.bsky.social review, including the mechanism of GLP-1 drugs, by @clemmensenc.bsky.social and colleagues, open-access
www.cell.com/cell/fulltex...

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...

High-intensity exercise → lactate signaling → neurogenesis? Yes (in some brain areas), but forced treadmill stress might be a potential confounding factor. We unpack this and propose some solutions in our latest JC article in The Journal of Physiology (@jphysiol.bsky.social): doi.org/10.1113/JP28...

𝐋𝐄𝐀𝐏2: 𝐀 𝐧𝐞𝐰 𝐡𝐨𝐫𝐦𝐨𝐧𝐞 𝐰𝐢𝐭𝐡 𝐛𝐢𝐠 𝐢𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦?

Research published today in @cp-cellrepmed.bsky.social shows that #insulin and #glucagon play a crucial role in regulating levels of LEAP2 - a newly discovered hormone with promise for treating cardiometabolic disease.

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New preprint on a cross-species atlas of the dorsal vagal complex and neural mediators of cagrilintide’s effects on energy balance @metabolcenter.bsky.social
>580,000 cells mapping to 89 rat, mice and rhesus macaque cell populations!

www.biorxiv.org/content/10.1...

#Neuroscience #Obesity

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Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/

On #WorldObesityDay, we have contributed a SnapShot to a special Issue on Obesity in @cp-cellmetabolism.bsky.social covering brain actions of the current and emerging weight loss drugs. @jonaspetersen.bsky.social @johansenvbi.bsky.social

Free access link: authors.elsevier.com/a/1kiaA5WXUlaX…

I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism
www.nature.com/articles/s41...

www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort

1/3 Kicking off my 🦋 journey with news that my lab has been awarded an ERC Consolidator Grant! Feeling incredibly proud and grateful. The project builds on our long-term focus: homeostatic control of body weight and pharmacological approaches for sustained weight loss. cbmr.ku.dk/news/2024/er...

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5