Johannes Hagen
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johanneshagen.bsky.social
Johannes Hagen
@johanneshagen.bsky.social
PhD student @osman-lab.bsky.social interested in mitochondrial DNA quality control mechanisms
Reposted by Johannes Hagen
Din Baruch, Maya Schuldiner, Ofir Klein and colleagues create and validate a proteome-wide yeast library for protein detection and analysis.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
September 22, 2025 at 1:05 PM
Reposted by Johannes Hagen
Please repost: Do you want to be part of the LSM Graduate school? Apply now for projects in Bioinformatics, Cell and Molecular Biology, Neurosciences, Genetics, Plant Sciences & Microbiology at www.portal.graduatecenter.lmu.de/ocgc/lsm
🗓️Deadline: 24.10.2025, 12:00 CET noon !
youtu.be/Xu2au-cX2pQ?...
Graduate School Life Science Munich LSM
YouTube video by Ludwig-Maximilians-Universität München
youtu.be
September 10, 2025 at 10:32 AM
Reposted by Johannes Hagen
🚨 Preprint alert! 🚨
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria

www.biorxiv.org/content/10.1...
Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection
The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP pr...
www.biorxiv.org
August 12, 2025 at 7:49 AM
Reposted by Johannes Hagen
🏁A big thank you to Marco Chierici and all the attendees of the course “Advanced Python for Data Science and Bioinformatics”!
The success of this course was driven by your enthusiasm and involvement.
Good luck with your data and projects!🦾💯
July 3, 2025 at 10:48 AM
Reposted by Johannes Hagen
🚀 We've just kicked off our Advanced Python for #DataScience & #Bioinformatics course with Dr. Marco Chierici!
A fantastic group of participants is ready to level up their Python skills and dive deep into real-world applications. Let's code! 🐍💻
June 30, 2025 at 9:47 AM
Reposted by Johannes Hagen
🎉 50 years of the Faculty of #Biology - and 20 years of interdisciplinary work at the #Biocenter! “Biology today is a big data science,” says Professor Stibor. AI, biodiversity loss & synthetic biology will be key topics of the future.📖 To the interview: www.lmu.de/en/newsroom/...
May 20, 2025 at 10:19 AM
Reposted by Johannes Hagen
As part of The Insight Series – Conversations with the Experts we had the pleasure of speaking with Dr. Silke Robatzek who is an ERC Grant holder and a leading researcher in the Genetics Dept at the LMU Biocenter
We hope she motivates you as much as she has inspired us!
#WomenInScience #Plants #Biol
April 9, 2025 at 3:56 PM
Reposted by Johannes Hagen
MITOtalks this week
April 1, 2025 at 4:10 PM
Reposted by Johannes Hagen
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:05 PM
Reposted by Johannes Hagen
Another insightful week with papers on the quality control on nucleoids and unimported mitochondrial protein, with new information on the transcriptional control of PINK1 by SMAD3.

In another issue of #mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

In collaboration with @biomednews.bsky.social
March 16, 2025 at 5:10 PM
Reposted by Johannes Hagen
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
www.biorxiv.org
February 16, 2025 at 2:04 PM
Reposted by Johannes Hagen
@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ?

@felix_thoma on 𝕏 Apr 25, 2022
"Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse"

need this here!
December 5, 2024 at 11:06 AM