Joel Steele 🧪💉⚡💥📹
@joelissteele.bsky.social
Palawa Man ❤💛🖤, Proteomics Lead @Monash Research Fellow, obsessed with #Proteomics and MassSpec 🧪💉⚡💥📹 | #FulbrightAlumni @NASA| views expressed are my own
🚀 Exciting times at Monash Proteomics & Metabolomics!
Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)
Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)
Monash University's Proteomics & Metabolomics Platform Strengthens Partnerships with Seer and Thermo Fisher Scientific
Monash University's Proteomics & Metabolomics Platform is set to revolutionise the field of proteomics and multiomics with its latest partnerships with Seer, Inc. and Thermo Fisher Scientific. This co...
www.monash.edu
February 25, 2025 at 7:57 AM
🚀 Exciting times at Monash Proteomics & Metabolomics!
Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)
Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)
Reposted by Joel Steele 🧪💉⚡💥📹
A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate
- toxin/antitoxin pairs
- anti-CRISPR proteins
+ a database of 120B synthetic base pairs
www.biorxiv.org/content/10.1...
@brianhie.bsky.social
- toxin/antitoxin pairs
- anti-CRISPR proteins
+ a database of 120B synthetic base pairs
www.biorxiv.org/content/10.1...
@brianhie.bsky.social
December 18, 2024 at 10:14 PM
A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate
- toxin/antitoxin pairs
- anti-CRISPR proteins
+ a database of 120B synthetic base pairs
www.biorxiv.org/content/10.1...
@brianhie.bsky.social
- toxin/antitoxin pairs
- anti-CRISPR proteins
+ a database of 120B synthetic base pairs
www.biorxiv.org/content/10.1...
@brianhie.bsky.social
🚨 Exciting research alert! 🚨
New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟
Details: shorturl.at/G0FHr
New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟
Details: shorturl.at/G0FHr
December 11, 2024 at 2:23 AM
🚨 Exciting research alert! 🚨
New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟
Details: shorturl.at/G0FHr
New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟
Details: shorturl.at/G0FHr
OUTSTANDING PAPER !!!!!
One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.
ProHap: A New Tool for Capturing Genetic Diversity in Proteomics
communities.springernature.com
December 11, 2024 at 2:09 AM
OUTSTANDING PAPER !!!!!
Reposted by Joel Steele 🧪💉⚡💥📹
One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.
ProHap: A New Tool for Capturing Genetic Diversity in Proteomics
communities.springernature.com
December 10, 2024 at 3:41 AM
One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.
Reposted by Joel Steele 🧪💉⚡💥📹
“The genetic architecture of protein stability” 🧪🧶🧬
An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5
www.biorxiv.org/content/10.1...
An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5
www.biorxiv.org/content/10.1...
October 28, 2023 at 5:49 AM
“The genetic architecture of protein stability” 🧪🧶🧬
An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5
www.biorxiv.org/content/10.1...
An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5
www.biorxiv.org/content/10.1...
Reposted by Joel Steele 🧪💉⚡💥📹
Podcasting help: @proteomicsnews.bsky.social and I record shows remotely using Squadcast, and that works great. But as conferences approach we’ve talked about recording in-person. But I don’t know exactly how. Do we just hook up a bunch of mics and splitters to a MacBook? tascam? mixing board? Help!
October 6, 2023 at 12:06 PM
Podcasting help: @proteomicsnews.bsky.social and I record shows remotely using Squadcast, and that works great. But as conferences approach we’ve talked about recording in-person. But I don’t know exactly how. Do we just hook up a bunch of mics and splitters to a MacBook? tascam? mixing board? Help!
Reposted by Joel Steele 🧪💉⚡💥📹
I'm especially excited about this year's courses. The entire curriculum was shaken up, almost every course removed to make room for the new vision and directions of human proteome research! 🧪 🧬
US HUPO 2024 in Portland is going to have an incredible line up of short courses! You can even attend these without attending the whole conference, but you should probably come to the conference too. Anyways, register here if you want: na.eventscloud.com/ereg/index.p...
#proteomics
#proteomics
October 4, 2023 at 9:04 PM
I'm especially excited about this year's courses. The entire curriculum was shaken up, almost every course removed to make room for the new vision and directions of human proteome research! 🧪 🧬
Reposted by Joel Steele 🧪💉⚡💥📹
Our comparison of two high-throughput plasma proteomics platforms is out today in Nature: www.nature.com/articles/s41...
By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.
By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.
Large-scale plasma proteomics comparisons through genetics and disease associations - Nature
Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves...
www.nature.com
October 4, 2023 at 4:46 PM
Our comparison of two high-throughput plasma proteomics platforms is out today in Nature: www.nature.com/articles/s41...
By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.
By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.
Reposted by Joel Steele 🧪💉⚡💥📹
Inaugural #POTRHList on Bluesky, w/ @leannewg.bsky.social, @ucdproteomics.bsky.social and I (likely poorly threaded).
Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...
1/n
Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...
1/n
From volcanoes to the bench: Advantages of novel hyperthermoacidic archaeal proteases for proteomics...
Here we introduce hyperthermoacidic archaeal proteases (HTA-Proteases©) isolated from organisms that thrive in nearly boiling acidic volcanic springs …
www.sciencedirect.com
October 4, 2023 at 6:52 PM
Inaugural #POTRHList on Bluesky, w/ @leannewg.bsky.social, @ucdproteomics.bsky.social and I (likely poorly threaded).
Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...
1/n
Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...
1/n
Reposted by Joel Steele 🧪💉⚡💥📹
Good blog post about how to approach the analysis of a two species proteomics experiment.
github.com/pwilmart/Hum...
github.com/pwilmart/Hum...
October 4, 2023 at 11:19 PM
Good blog post about how to approach the analysis of a two species proteomics experiment.
github.com/pwilmart/Hum...
github.com/pwilmart/Hum...