Janssen Kotah, PhD 🇵🇭
@jmkotah.bsky.social
Filipino neurobiologist working at the Bart Eggen lab (University Medical Center Groningen, NL). Studying neurodegenerative diseases with single cell and spatial transcriptomics techniques. https://jmkotah.github.io/
I'm very happy to share that our work describing a geospatial approach to allocating transcripts for single cell spatial transcriptomics (in human brains) using the 10x Xenium platform is now out in @commsbio.nature.com! @barteggen.bsky.social @kooistrasm.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features - Communications Biology
Investigating the suitability of different strategies for transcript allocation, including nuclear borders, expanded nuclear borders, and post-run immunostaining masks, for in situ sequencing data gen...
www.nature.com
July 23, 2025 at 10:20 AM
I'm very happy to share that our work describing a geospatial approach to allocating transcripts for single cell spatial transcriptomics (in human brains) using the 10x Xenium platform is now out in @commsbio.nature.com! @barteggen.bsky.social @kooistrasm.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Janssen Kotah, PhD 🇵🇭
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
December 18, 2024 at 2:50 PM
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
Reposted by Janssen Kotah, PhD 🇵🇭
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 3:49 PM
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Reposted by Janssen Kotah, PhD 🇵🇭
🚨New paper out in Nature Mental Health from my work with @erindunnscd.bsky.social at #MassGeneral! We found that childhood adversity leads to #epigenetic changes that can increase OR reduce risk for depression. Let me explain... 🧵(1/6)
Read the paper here: www.nature.com/articles/s44...
Read the paper here: www.nature.com/articles/s44...
December 2, 2024 at 8:11 PM
🚨New paper out in Nature Mental Health from my work with @erindunnscd.bsky.social at #MassGeneral! We found that childhood adversity leads to #epigenetic changes that can increase OR reduce risk for depression. Let me explain... 🧵(1/6)
Read the paper here: www.nature.com/articles/s44...
Read the paper here: www.nature.com/articles/s44...
Reposted by Janssen Kotah, PhD 🇵🇭
Happy to share that our work on the impact of stress on human milk microbiome is now published in BBI! Great work lead by Hannah Juncker!! www.sciencedirect.com/science/arti...
Maternal stress in the early postpartum period is associated with alterations in human milk microbiome composition
Maternal stress is associated with negative early-life development and (mental)health outcomes. There is recent evidence that maternal stress in the p…
www.sciencedirect.com
November 25, 2024 at 3:13 PM
Happy to share that our work on the impact of stress on human milk microbiome is now published in BBI! Great work lead by Hannah Juncker!! www.sciencedirect.com/science/arti...
Reposted by Janssen Kotah, PhD 🇵🇭
Wishing the Elsevier editors who desk-accepted this all the best for their next career moves.
doi.org/10.1016/j.ij...
doi.org/10.1016/j.ij...
November 22, 2024 at 2:49 PM
Wishing the Elsevier editors who desk-accepted this all the best for their next career moves.
doi.org/10.1016/j.ij...
doi.org/10.1016/j.ij...
Reposted by Janssen Kotah, PhD 🇵🇭
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
November 14, 2024 at 3:21 AM
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!