@jkropski.bsky.social
Pulmonary/Critical Care Physician/Scientist. IPF. Single-cell/lung biology. Personal account - opinions are my own.
Reposted
Great new work led by Aaron Kwok from @davisjmcc.bsky.social’s group. A tool to “denoise” contaminating transcripts from image based spatial data.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Denoising image-based spatial transcriptomics data with DenoIST
Image-based spatial transcriptomics (IST) technologies provide unprecedented resolution of gene expression in tissue sections, but suffer from contamination of cells' gene expression profiles due to i...
www.biorxiv.org
November 15, 2025 at 1:31 PM
Great new work led by Aaron Kwok from @davisjmcc.bsky.social’s group. A tool to “denoise” contaminating transcripts from image based spatial data.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
A show of bipartisan support for NIH. Basically flat except for ARPA-H.
The President’s budget proposal basically ignored (as it should have been).
The President’s budget proposal basically ignored (as it should have been).
House LHHC bill is out. Lots of hits to HHS, but the top line number for NIH is 1% decrease, mostly due to cuts ARPA-H. This seems like a huge rejection of the president's budget request.
democrats-appropriations.house.gov
September 2, 2025 at 12:37 AM
A show of bipartisan support for NIH. Basically flat except for ARPA-H.
The President’s budget proposal basically ignored (as it should have been).
The President’s budget proposal basically ignored (as it should have been).
Reposted
So excited to share @saahimall.bsky.social just had her her first 1st author publication published in AJP lung! Huge accomplishment!!! This study wouldn't have been possible without the amazing @jensucre.bsky.social!
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity | American Journal of Physiology-Lung Cellular and Molecular Physiology | American Physiological So...
A molecular understanding of lung organogenesis requires delineation of the timing and regulation of the cellular transitions that ultimately form and support a surface capable of gas exchange. While ...
journals.physiology.org
August 4, 2025 at 10:25 PM
So excited to share @saahimall.bsky.social just had her her first 1st author publication published in AJP lung! Huge accomplishment!!! This study wouldn't have been possible without the amazing @jensucre.bsky.social!
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Reposted
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
July 30, 2025 at 4:00 AM
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
Reposted
Congrats to @saahimall.bsky.social on her first study from her PhD! Also, science is always more fun when done with friends. Great to work as always with @jensucre.bsky.social and @jkropski.bsky.social!
A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity https://www.biorxiv.org/content/10.1101/2025.06.02.656433v1
June 5, 2025 at 5:37 PM
Congrats to @saahimall.bsky.social on her first study from her PhD! Also, science is always more fun when done with friends. Great to work as always with @jensucre.bsky.social and @jkropski.bsky.social!
New spatial paper from Saahi and VUMC/TGen LungMAP team with SCRI colleagues! @nebanovich.bsky.social @jensucre.bsky.social
A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity https://www.biorxiv.org/content/10.1101/2025.06.02.656433v1
June 5, 2025 at 5:21 PM
New spatial paper from Saahi and VUMC/TGen LungMAP team with SCRI colleagues! @nebanovich.bsky.social @jensucre.bsky.social
Congratulations to Serges, Dawn, Tina and team! Single-cell insights into how early life RSV infection contributes to asthma risk.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development
Airway epithelial cells from children with wheeze are characterized by altered development and susceptibility to RSV infection.
www.science.org
May 24, 2025 at 12:23 PM
Congratulations to Serges, Dawn, Tina and team! Single-cell insights into how early life RSV infection contributes to asthma risk.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations to our amazing IP colleagues - really important paper addressing approach to diagnosis of pulmonary nodules out in NEJM- www.nejm.org/doi/full/10....
Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules | NEJM
Each year, millions of pulmonary nodules are identified incidentally or through lung
cancer screening, and many involve biopsy to distinguish cancer from benign processes.
Both navigational broncho...
www.nejm.org
May 19, 2025 at 11:02 PM
Congratulations to our amazing IP colleagues - really important paper addressing approach to diagnosis of pulmonary nodules out in NEJM- www.nejm.org/doi/full/10....
Reposted
Since this was published yesterday, NPR reports JAMA joins NEJM on the list of journals that confirms they’ve been sent threatening letters by Trump’s DOJ, ominously referencing their tax-exempt status in a bid to compel regime-friendly editorial choices.
www.scientificamerican.com/article/the-...
www.scientificamerican.com/article/the-...
The Scary Implications of U.S. Government Attacks on Medical Journals
A Trump-aligned prosecutor’s attack on medical journals is a threat to your health care—and the medical establishment should not comply
www.scientificamerican.com
May 2, 2025 at 10:10 PM
Since this was published yesterday, NPR reports JAMA joins NEJM on the list of journals that confirms they’ve been sent threatening letters by Trump’s DOJ, ominously referencing their tax-exempt status in a bid to compel regime-friendly editorial choices.
www.scientificamerican.com/article/the-...
www.scientificamerican.com/article/the-...
Reposted
This is definitely worth a read... This is what conscience and courage look like...
www.atsjournals.org/doi/10.1513/...
1/n
www.atsjournals.org/doi/10.1513/...
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With Sadness and Resolve: Why I Resigned as Chief Medical Officer of an NIH Institute and What Comes Next | Annals of the American Thoracic Society | Articles in Press
www.atsjournals.org
April 27, 2025 at 12:18 PM
This is definitely worth a read... This is what conscience and courage look like...
www.atsjournals.org/doi/10.1513/...
1/n
www.atsjournals.org/doi/10.1513/...
1/n
Reposted
😍
The March issue of @naturegenet.bsky.social is live!
Featuring:
✅spatial transcriptomics in pulmonary fibrosis
✅clonal hematopoiesis
✅psychiatric disorders across sex
✅PD-L1 succinylation in melanoma
✅human microglia isoform atlas
✅genomic analyses in Citrus
& more
⬇️
www.nature.com/ng/volumes/5...
Featuring:
✅spatial transcriptomics in pulmonary fibrosis
✅clonal hematopoiesis
✅psychiatric disorders across sex
✅PD-L1 succinylation in melanoma
✅human microglia isoform atlas
✅genomic analyses in Citrus
& more
⬇️
www.nature.com/ng/volumes/5...
March 18, 2025 at 4:38 PM
😍
Reposted
So excited that our study made the cover of Nature Genetics this month!
March 17, 2025 at 3:21 PM
So excited that our study made the cover of Nature Genetics this month!
Reposted
How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.
The NIH. That's just the economic benefit.
Biomedical research promotes human health.
February 10, 2025 at 5:27 PM
How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.
The NIH. That's just the economic benefit.
Biomedical research promotes human health.