Jakub Kopycinski
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jkopy.bsky.social
Jakub Kopycinski
@jkopy.bsky.social
310 followers 1.7K following 14 posts
Vaccine immunologist, Arsenal fan and fatigued rugby dad.
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Reposted by Jakub Kopycinski
labliston.bsky.social
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Reposted by Jakub Kopycinski
matthewcobb.bsky.social
Hey Colossal - spend some of your money on saving this real bird!
October 7, 2025 at 6:35 AM
Reposted by Jakub Kopycinski
mpibiochem.bsky.social
An interdisciplinary study uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy.

❕Publication: www.cell.com/cancer-cell/...

❕Press Release: www.biochem.mpg.de/when-tumors-...
June 26, 2025 at 5:27 PM
Reposted by Jakub Kopycinski
labwaggoner.bsky.social
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
July 18, 2025 at 7:07 PM
Reposted by Jakub Kopycinski
labwaggoner.bsky.social
A microfluidic chip-based antigen-specific T-cell response assay (ASTRA) that automates the detection of M.tb-specific T-cell activation responses to facilitate screening for latent M.tb infection and TB
www.nature.com/articles/s41...
‪@natbiomedeng.nature.com‬
June 27, 2025 at 6:25 PM
Reposted by Jakub Kopycinski
arseblog.com
www.vulture.com/article/zohr...
June 25, 2025 at 7:10 AM
jkopy.bsky.social
I've just signed "Stop the Oxford Congestion Charge" - Will you support the campaign too? actionstorm.org/petitions/st...
actionstorm.org
June 22, 2025 at 8:55 AM
Reposted by Jakub Kopycinski
jkagan1.bsky.social
mRNAs encoding adjuvant proteins boost immunity. A fantastic study from Hunter et al shows the value of IL12. Study validates original work on this concept, ref below.
Kudos to the authors on this exciting discovery!
www.science.org/doi/10.1126/...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 7, 2025 at 12:40 PM
Reposted by Jakub Kopycinski
sailorrooscout.bsky.social
The study has been published in Science. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...
• www.scripps.edu/news-and-eve...
ABSTRACT A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SHM) and produce bnAbs. In two randomized, open-label phase 1 human clinical trials, IAVI-G002 in the United States and IAVI-G003 in Rwanda and South Africa, we evaluated the safety and immunogenicity of mRNA-encoded nanoparticles as priming immunogens (both trials) and first-boosting immunogens (IAVI-G002). The vaccines were generally safe and well tolerated, except 18% of IAVI-G002 participants experienced skin reactions. Priming induced bnAb precursors with substantial frequencies and SHM, and heterologous boosting elicited increased SHM, affinity, and neutralization activity toward bnAb development. The results establish clinical proof of concept that heterologous boosting can advance bnAb-precursor maturation and demonstrate bAb priming in Africa where the HIV burden is highest. FUNDING This work was supported by funding from the Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVIMC INV-007368, CAVIMC INV-036842, CCVIMC INV-007371, VISC INV-008017, INV-032929, CAVD network INV-002916, VxPDC INV-008352, INV-007375, NAC INV-007522, INV-008813, INV-007385 and INV-005175); IAVI (IAVI 167627819, |AVI A0803); the lAVI Neutralizing Antibody Center; the National Institute of Allergy and Infectious Diseases (NIAID) (UM1 Al100663 and UM1 Al144462); the Intramural Research Program of NIAID; the Swedish Research Council (2017-00968); Moderna, Inc.; the U.S. Agency for International Development (USAID) (AID-5 OAA-A-16-00032 and IAVI A11257); and the U.S. President's Emergency Plan for AIDS Relief. Two phase 1 clinical trials tested the first steps of a germline-targeting HIV vaccine strategy to induce broadly neutralizing antibodies (bnAbs). A nanoparticle antigen (multicolored sphere) delivered via mRNA activated immune cells, including bnAb precursor B cells (red) and other B cells (blue). The red cells began producing bnAb precursors (red Y-shapes). In one trial (IAVI G002), a second, distinct nanoparticle antigen (larger multicolored sphere) further guided those precursors toward developing the features of bnAbs. Credit: Scripps Research Fig. S1. Conceptual schematic for germline-targeting vaccine design.
May 16, 2025 at 4:01 PM
Reposted by Jakub Kopycinski
joescaramanga.co.uk
I Know What You Did Last Supper
discussingfilm.net DiscussingFilm @discussingfilm.net · May 15
‘THE PASSION OF THE CHRIST 2’ has been officially titled…

‘THE RESURRECTION OF CHRIST’
May 15, 2025 at 5:38 PM
Reposted by Jakub Kopycinski
davidho.bsky.social
Nobel Prize winning science.
Moderna's combo Covid and flu mRNA shot outperforms current vaccines in large trial
A combination shot would make it easier for people to get vaccinated against Covid and the flu at the same time.
www.nbcnews.com
May 10, 2025 at 9:46 AM
Reposted by Jakub Kopycinski
ox.ac.uk
Congratulations to

- Prof Véronique Gouverneur
- Prof Desmond King
- Prof Andrew McMichael
- Prof Gero Miesenböck

Read more ⬇️
Four Oxford researchers elected to the US National Academy of
Last week, the National Academy of Sciences in the US announced the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original
www.ox.ac.uk
May 6, 2025 at 11:38 AM
Reposted by Jakub Kopycinski
jenjuno.viralvaxlab.com
As a first #ImmunoSky post, I’m excited to share our latest pre-print, by the fantastic Mitchell Zheng!

www.biorxiv.org/content/10.1...

Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. 🧵 1/9
www.biorxiv.org
December 20, 2024 at 3:39 AM
Reposted by Jakub Kopycinski
jenjuno.viralvaxlab.com
Happy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances!

www.science.org/doi/10.1126/...

Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab
April 27, 2025 at 5:07 PM
Reposted by Jakub Kopycinski
labwaggoner.bsky.social
CXCR4 down-regulation deconvolutes TCR-independent activation in the AIM assay
www.science.org/doi/10.1126/...
April 25, 2025 at 6:17 PM
Reposted by Jakub Kopycinski
labwaggoner.bsky.social
OMIP-114: A 36-Color Spectral Flow Cytometry Panel for Detailed Analysis of T Cell Activation and Regulation in Small Human Blood Volumes
onlinelibrary.wiley.com/doi/full/10....
April 23, 2025 at 7:41 PM
Reposted by Jakub Kopycinski
itaiyanai.bsky.social
In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.
April 21, 2025 at 11:31 AM
jkopy.bsky.social
@arseblog.com a very…
April 17, 2025 at 5:25 AM
Reposted by Jakub Kopycinski
science.org
Quantum dots feature widely tunable and distinctive optical, electrical, chemical, and physical properties. They span energy harvesting, illumination, displays, cameras, and more.

Read more on #WorldQuantumDay: scim.ag/4j6gJOl
Semiconductor quantum dots: Technological progress and future challenges
A review highlights advances in the synthesis of colloidal quantum dots that have enabled numerous applications.
scim.ag
April 14, 2025 at 3:39 PM
Reposted by Jakub Kopycinski
labliston.bsky.social
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!

We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!

www.nature.com/articles/s41...
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
www.nature.com
April 14, 2025 at 8:53 AM
Reposted by Jakub Kopycinski
marcveld.bsky.social
Robust T cell responses to Pfizer/BioNTech vaccine compared to infection and evidence of attenuated peripheral CD8+ T cell responses due to COVID-19

Sounds ominous, but is it? Good vaccine responses but less viral responses..... or is context needed?

(X, Mar 20, 2023)

www.cell.com/immunity/ful...
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection
Our understanding of T cell responses in COVID-19 and vaccination is incomplete. Gao et al. examine SARS-CoV-2-specific T cell responses to infection and vaccination, revealing disparate kinetics betw...
www.cell.com
February 27, 2025 at 8:53 PM
Reposted by Jakub Kopycinski
arindam92.bsky.social
I am super happy to share our latest article entitled "Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy", now published in Science www.science.org/doi/10.1126/...
It was my postdoctoral work mit @sauer-lab.bsky.social Congrats to all the co-authors!
January 10, 2025 at 2:07 PM
Reposted by Jakub Kopycinski
sailorrooscout.bsky.social
THIS IS HUGE! Researchers at Scripps Research Institute have developed a groundbreaking UNIVERSAL coronavirus vaccine that triggers STONG immune responses AND shows promise in neutralizing MULTIPLE coronaviruses, including those responsible for causing COVID-19, MERS, AND even the “common cold.” 🧪🧵⬇️
March 27, 2025 at 4:00 PM
Reposted by Jakub Kopycinski
labwaggoner.bsky.social
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
March 18, 2025 at 4:36 PM