Along the path, we improved methods that can be useful for the whole field - from a new segmentation method over scmorph to strategies for quality control. Lots more in the preprint, so do check it out if you are interested in microRNAs, cell morphology and how it can be used to create vast […]

Among the 18 miRNAs was miR-155-5p, whose activity we could link to its sequence, showing that it subtly affects cell morphology in human and mouse cells. In fact, we found that miRNAs with more similar sequence also produced more similar cell morphologies! […]

[Original post on genomic.social]

Hundreds of miRNAs changed cell morphology! But only very few of them did so across cell lines (we tested five: three human and two mouse lines). But a subset of 18 miRNAs did! This is interesting because we know that miRNAs' activity depends on the context […]

[Original post on genomic.social]

We tested over 4,000 microRNAs and looked at whether they changed cell organelles, which we made visible with a technique called Cell Painting. To sift through the 100,000+ microscopy pictures, we translated the pictures into numbers. We were looking for changes in subpopulations of cells and […]

@eliocamp seeing as your profile suggests you are used to R, you might like plotnine which gives ggplot2-like syntax. What's really missing is all the extensions to ggplot2, but of course it's impossible to port them all.