Jesko Wagner
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jeskowagner.genomic.social.ap.brid.gy
Jesko Wagner
@jeskowagner.genomic.social.ap.brid.gy
5 followers 1 following 10 posts
PhD researcher in Edinburgh, researching how to find better treatments faster.
https://jeskowagner.github.io
#Bioinformatics
#DrugDiscovery
#BioImaging
#Genomics

[bridged from https://genomic.social/@jeskowagner on the fediverse by https://fed.brid.gy/ ]
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jeskowagner.genomic.social.ap.brid.gy
Among the 18 miRNAs was miR-155-5p, whose activity we could link to its sequence, showing that it subtly affects cell morphology in human and mouse cells. In fact, we found that miRNAs with more similar sequence also produced more similar cell morphologies! […]

[Original post on genomic.social]
A violin graph, showing that greater sequence similarity is associated with greater morphological similarity.
November 15, 2025 at 2:52 PM
jeskowagner.genomic.social.ap.brid.gy
Hundreds of miRNAs changed cell morphology! But only very few of them did so across cell lines (we tested five: three human and two mouse lines). But a subset of 18 miRNAs did! This is interesting because we know that miRNAs' activity depends on the context […]

[Original post on genomic.social]
A five way Venn diagram, describing how many miRNAs significantly impacted cell morphology in which cell line. Sections, including overlaps, are numbered, with the cell line C2C12 exhibiting the highest number of significant miRNAs. A heatmap showing 18 miRNAs that altered cell morphology in more than one cell line. Among them is miR-155-5p.
November 15, 2025 at 2:48 PM