Jelle van den Ameele
@jellevda.bsky.social
Reposted by Jelle van den Ameele
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS
Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow
rdcu.be
October 15, 2025 at 10:10 AM
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS
Reposted by Jelle van den Ameele
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Reposted by Jelle van den Ameele
Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️
As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
October 10, 2025 at 8:45 AM
Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️
As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
Reposted by Jelle van den Ameele
This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social
📢 BREAKING NEWS!
The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients
A huge milestone for the mito community! 💥
www.thelilyfoundation.org.uk/news/first-e...
@mitocamb.bsky.social
The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients
A huge milestone for the mito community! 💥
www.thelilyfoundation.org.uk/news/first-e...
@mitocamb.bsky.social
August 7, 2025 at 11:34 AM
Reposted by Jelle van den Ameele
📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics @cam.ac.uk @mrc-mbu.bsky.social @camneurodept.bsky.social @jellevda.bsky.social It's a great time to join this dynamic and world leading team working on #mitochondria Closes 28/8/25
www.cam.ac.uk/jobs/senior-...
www.cam.ac.uk/jobs/senior-...
Senior Research Associate (Fixed Term)
Nuclear-mitochondrial genetic interactions in health and neurodegenerative diseases Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. The University of
www.cam.ac.uk
August 1, 2025 at 1:50 PM
📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics @cam.ac.uk @mrc-mbu.bsky.social @camneurodept.bsky.social @jellevda.bsky.social It's a great time to join this dynamic and world leading team working on #mitochondria Closes 28/8/25
www.cam.ac.uk/jobs/senior-...
www.cam.ac.uk/jobs/senior-...
Reposted by Jelle van den Ameele
Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.
May 23, 2025 at 2:43 PM
Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.
Reposted by Jelle van den Ameele
Thanks to @lilyfoundation.bsky.social for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre! #mito @ucl-qs-cnmd.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social
May 8, 2025 at 4:43 PM
Thanks to @lilyfoundation.bsky.social for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre! #mito @ucl-qs-cnmd.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social
Reposted by Jelle van den Ameele
We spent a great afternoon at the House of Lords for the launch of the @lifearc.bsky.social Centre for #Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…
May 7, 2025 at 8:13 PM
We spent a great afternoon at the House of Lords for the launch of the @lifearc.bsky.social Centre for #Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…
Reposted by Jelle van den Ameele
It was a great day and a fantastic #PPIE workshop!! @lifearc.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @dwong47.bsky.social @mitogene.bsky.social @mrc-mbu.bsky.social @mitonewcastle.bsky.social @uclqsion.bsky.social
Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
April 15, 2025 at 6:36 PM
Reposted by Jelle van den Ameele
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Reposted by Jelle van den Ameele
2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply!
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social
📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
April 11, 2025 at 6:23 AM
2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply!
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social
Reposted by Jelle van den Ameele
Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 4, 2025 at 8:52 AM
Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jelle van den Ameele
We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) - Job Opportunities - University of Cambridge
Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) in the Division of Neurology at the University of Cambridge.
www.jobs.cam.ac.uk
April 2, 2025 at 1:52 PM
We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
Reposted by Jelle van den Ameele
Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 20, 2025 at 4:38 AM
Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jelle van den Ameele
All the jobs, all in one place!!
February 28, 2025 at 2:42 PM
All the jobs, all in one place!!
Reposted by Jelle van den Ameele
📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
February 28, 2025 at 10:56 AM
📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator
Join us! Links below.
Reposted by Jelle van den Ameele
We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫
Come join me and my lab in beautiful Copenhagen. 🇩🇰
PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK
Come join me and my lab in beautiful Copenhagen. 🇩🇰
PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
February 26, 2025 at 10:37 AM
We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫
Come join me and my lab in beautiful Copenhagen. 🇩🇰
PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK
Come join me and my lab in beautiful Copenhagen. 🇩🇰
PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK
Reposted by Jelle van den Ameele
BBC news article about one of our patients with #neuroferritinopathy on the DefINe clinical trial, funded by #LifeArc. Spread the word about this disease, and also this trial - more participants needed!
www.bbc.com/news/article...
@ritahorvath.bsky.social @jellevda.bsky.social
www.bbc.com/news/article...
@ritahorvath.bsky.social @jellevda.bsky.social
Brain drug cure needed for future 'trapped in' generations
Scientists hope to find a cure for a genetic condition linked back to a single Cumbrian family line.
www.bbc.com
February 11, 2025 at 10:08 AM
BBC news article about one of our patients with #neuroferritinopathy on the DefINe clinical trial, funded by #LifeArc. Spread the word about this disease, and also this trial - more participants needed!
www.bbc.com/news/article...
@ritahorvath.bsky.social @jellevda.bsky.social
www.bbc.com/news/article...
@ritahorvath.bsky.social @jellevda.bsky.social
Reposted by Jelle van den Ameele
Very excited to share this #LifeArc video about the 4 new #rare disease centres across the UK, with our centre for #mitochondrial diseases being one of them!
@jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
@jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
LifeArc on LinkedIn: Rare disease research faces unique challenges including lack of…
Rare disease research faces unique challenges including lack of investment, small patient populations, fragmented research and challenging routes to…
www.linkedin.com
January 29, 2025 at 10:54 AM
Very excited to share this #LifeArc video about the 4 new #rare disease centres across the UK, with our centre for #mitochondrial diseases being one of them!
@jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
@jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 27, 2025 at 7:38 PM
Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!
Reposted by Jelle van den Ameele
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Jelle van den Ameele
Final week to apply for this research coordinator position, working on all things #mito & the LifeArc centre for rare diseases. Join us! www.jobs.cam.ac.uk/job/48491/
@ritahorvath.bsky.social @jellevda.bsky.social
@ritahorvath.bsky.social @jellevda.bsky.social
Research Coordinator (Fixed Term) - Job Opportunities - University of Cambridge
Research Coordinator (Fixed Term) in the Division of Neurology at the University of Cambridge.
www.jobs.cam.ac.uk
January 18, 2025 at 10:45 AM
Final week to apply for this research coordinator position, working on all things #mito & the LifeArc centre for rare diseases. Join us! www.jobs.cam.ac.uk/job/48491/
@ritahorvath.bsky.social @jellevda.bsky.social
@ritahorvath.bsky.social @jellevda.bsky.social
Reposted by Jelle van den Ameele
For any patients (or researchers) interested in #mito research, the Lily Foundation has launched its new 'research zone': www.thelilyfoundation.org.uk/affected-by-...
@ritahorvath.bsky.social @jellevda.bsky.social
@ritahorvath.bsky.social @jellevda.bsky.social
Research Zone - The Lily Foundation
Your hub for the latest news, views and breakthroughs in mitochondrial disease research. categories: Research on the road,Researcher spotlight,PPIE round-up,Science unwrapped,Journal club,Trials hub
www.thelilyfoundation.org.uk
January 9, 2025 at 8:57 AM
For any patients (or researchers) interested in #mito research, the Lily Foundation has launched its new 'research zone': www.thelilyfoundation.org.uk/affected-by-...
@ritahorvath.bsky.social @jellevda.bsky.social
@ritahorvath.bsky.social @jellevda.bsky.social
Reposted by Jelle van den Ameele
New year, new bluesky account, and new website: mitocamb.medschl.cam.ac.uk
MitoCAMB - Cambridge Clinical Mitochondrial Research Group
Studying the genetic basis and mechanisms of mitochondrial diseases. Our aim is to provide a precise diagnosis and to discover new treatments.
mitocamb.medschl.cam.ac.uk
January 3, 2025 at 4:32 PM
New year, new bluesky account, and new website: mitocamb.medschl.cam.ac.uk