Jeff Lange
@jeffjlange.bsky.social
Microscopist, biologist, chemist
Opinions expressed are my own.
Opinions expressed are my own.
Reposted by Jeff Lange
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 5
Prompt DEER
Pdb 4YXH
Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.
Next: PIERCE
Suggestions?
Day 5
Prompt DEER
Pdb 4YXH
Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.
Next: PIERCE
Suggestions?
October 6, 2025 at 5:10 AM
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 5
Prompt DEER
Pdb 4YXH
Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.
Next: PIERCE
Suggestions?
Day 5
Prompt DEER
Pdb 4YXH
Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.
Next: PIERCE
Suggestions?
I don't use AI on an everyday basis or nearly at all. I have been looking for a paper which I remember that showed expansion of bio samples so large that they are visible to the naked eye. I asked copilot and it found it immediately. It even gave me a real link that worked. I am devastated.
November 5, 2025 at 2:33 AM
I don't use AI on an everyday basis or nearly at all. I have been looking for a paper which I remember that showed expansion of bio samples so large that they are visible to the naked eye. I asked copilot and it found it immediately. It even gave me a real link that worked. I am devastated.
Reposted by Jeff Lange
What makes #StowersGrad distinct from other #PhD programs? Our students are not limited to only learning under their PI. Experts throughout the Institute in our 16 Technology Centers offer additional learning opportunities.
Learn more + apply now: bit.ly/44VM6DI
Learn more + apply now: bit.ly/44VM6DI
October 24, 2025 at 11:18 PM
What makes #StowersGrad distinct from other #PhD programs? Our students are not limited to only learning under their PI. Experts throughout the Institute in our 16 Technology Centers offer additional learning opportunities.
Learn more + apply now: bit.ly/44VM6DI
Learn more + apply now: bit.ly/44VM6DI
Reposted by Jeff Lange
A new @sciam.bsky.social feature explores #research from the Halfmann Lab, revealing that our cells contain immune proteins that can instantly form crystals—triggering the cell to sacrifice itself when a virus invades. #SciSky
🔗 Read here: www.scientificamerican.com/article/cell...
🔗 Read here: www.scientificamerican.com/article/cell...
Cells Have a Death Switch That Protects Us from Viruses but Also Leads to Aging
A special class of immune proteins protect us from pathogens but also drive inflammation and cell death
www.scientificamerican.com
October 20, 2025 at 6:57 PM
A new @sciam.bsky.social feature explores #research from the Halfmann Lab, revealing that our cells contain immune proteins that can instantly form crystals—triggering the cell to sacrifice itself when a virus invades. #SciSky
🔗 Read here: www.scientificamerican.com/article/cell...
🔗 Read here: www.scientificamerican.com/article/cell...
It's always funny to see these. The bar for effort on these type emails is so low. I believe in you, you can do it.
![An image showing a salutation from an email I received that says "Dear Jeffrey," followed by "Dear [First Name],"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:k6adddrypjqnb36x7yqw7wzz/bafkreibnhbdwwcoc7ovn2uhhpys6xohqei3xlxsjf3oamaxb4cltu7yn3i@jpeg)
October 16, 2025 at 1:35 PM
It's always funny to see these. The bar for effort on these type emails is so low. I believe in you, you can do it.
Has anyone tried using mesoscope.scripps.edu/beta/index.h... and CellPAINT2D to try to illustrate/simulate phase separation? You can make multivalent interactions, but they don't unbind, at least that I can figure out.
October 10, 2025 at 2:05 PM
Has anyone tried using mesoscope.scripps.edu/beta/index.h... and CellPAINT2D to try to illustrate/simulate phase separation? You can make multivalent interactions, but they don't unbind, at least that I can figure out.
Reposted by Jeff Lange
This week is #CRC25 — our annual Crossroads Research Conference! A time for our community to connect, share discoveries, and spark new collaborations. Hear from attendees including @jeffjlange.bsky.social & @juliannahaug.bsky.social ⬇️
September 11, 2025 at 8:44 PM
This week is #CRC25 — our annual Crossroads Research Conference! A time for our community to connect, share discoveries, and spark new collaborations. Hear from attendees including @jeffjlange.bsky.social & @juliannahaug.bsky.social ⬇️
Reposted by Jeff Lange
Applications for our #PhD program are NOW OPEN! Our independently fully funded program allows students to focus entirely on #research & growth, exploring their own questions while learning from top experts in the field. #GradSchool
Apply now: bit.ly/44VM6DI
Apply now: bit.ly/44VM6DI
September 8, 2025 at 2:27 PM
Applications for our #PhD program are NOW OPEN! Our independently fully funded program allows students to focus entirely on #research & growth, exploring their own questions while learning from top experts in the field. #GradSchool
Apply now: bit.ly/44VM6DI
Apply now: bit.ly/44VM6DI
Reposted by Jeff Lange
Cnidarian-Microbe Interactions
Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred.
Contact Matt Gibson: mg2@stowers.org
Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred.
Contact Matt Gibson: mg2@stowers.org
August 14, 2025 at 4:50 PM
Cnidarian-Microbe Interactions
Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred.
Contact Matt Gibson: mg2@stowers.org
Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred.
Contact Matt Gibson: mg2@stowers.org
A little Friday distraction, is the sound a Mac plays when you turn it on the final chord from A Day in the Life by the Beatles? This is a clip of the song in question. youtube.com/clip/UgkxZZ3...
YouTube
Share your videos with friends, family, and the world
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August 29, 2025 at 2:16 PM
A little Friday distraction, is the sound a Mac plays when you turn it on the final chord from A Day in the Life by the Beatles? This is a clip of the song in question. youtube.com/clip/UgkxZZ3...
Sweet! Very excited to read this paper on the transcriptome AND proteome of stress granules both from yeast and mammalian after treatment with azide/arsenite. www.cell.com/cell-reports... I've always wondered if the contents are there by accident, or on purpose to maintain the phase/granule.
Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes
Demeshkina and Ferré-D'Amaré purify stress granule cores from yeast and mammalian
cells. These cytoplasmic ribonucleoproteins are a conserved response of eukaryotic
cells to stressors; their dysregula...
www.cell.com
June 8, 2025 at 1:42 PM
Sweet! Very excited to read this paper on the transcriptome AND proteome of stress granules both from yeast and mammalian after treatment with azide/arsenite. www.cell.com/cell-reports... I've always wondered if the contents are there by accident, or on purpose to maintain the phase/granule.
Reposted by Jeff Lange
Today we celebrate the accomplishments of our 2025 graduates! #GraduationDay #PhD
May 5, 2025 at 2:21 PM
Today we celebrate the accomplishments of our 2025 graduates! #GraduationDay #PhD
It's a beautiful day for disc golf!
May 3, 2025 at 6:26 PM
It's a beautiful day for disc golf!
Reposted by Jeff Lange
Meet Jeff Lange, Senior Research Scientist, in this #RoadToResearch Q&A!
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
Read more: bit.ly/3Fd0nVm
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
Read more: bit.ly/3Fd0nVm
Road to Research: Q&A with Jeff Lange, Senior Research Scientist
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
bit.ly
March 7, 2025 at 9:49 PM
Meet Jeff Lange, Senior Research Scientist, in this #RoadToResearch Q&A!
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
Read more: bit.ly/3Fd0nVm
"I hope to inspire early-career researchers to be curious and, in turn, have a far-reaching impact on humanity and human health as a whole."
Read more: bit.ly/3Fd0nVm
Reposted by Jeff Lange
I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
January 3, 2025 at 11:28 AM
I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
Reposted by Jeff Lange
The Institute mourns the loss of R. Scott Hawley, PhD. A brilliant scientist, cherished colleague, and true mentor. Scott's contributions to our understanding of genetics and passion for training the next generation of scientists will forever be remembered. bit.ly/3WPqqYG
Remembering R. Scott Hawley, Ph.D.
A Legacy of Scientific Excellence and Mentorship
bit.ly
February 4, 2025 at 6:12 PM
The Institute mourns the loss of R. Scott Hawley, PhD. A brilliant scientist, cherished colleague, and true mentor. Scott's contributions to our understanding of genetics and passion for training the next generation of scientists will forever be remembered. bit.ly/3WPqqYG
Deleting my 20 year old Facebook account. It's harder to do it than I thought it would be. I originally joined earlier than that when my University became eligible to join. But I nuked that first profile in 2004. Downloading your data takes time...plan ahead.
January 25, 2025 at 4:48 PM
Deleting my 20 year old Facebook account. It's harder to do it than I thought it would be. I originally joined earlier than that when my University became eligible to join. But I nuked that first profile in 2004. Downloading your data takes time...plan ahead.
Here's a way to brighten up your Friday! The manatees are back in Florida for the winter and that means you get to watch them on live webcam feeds. savethemanatee.org/manatees/web...
Enjoy!
Enjoy!
Webcams | Save the Manatee Club
Manatee webcams offer live footage of these gentle giants in their natural habitat, both above-water and underwater. Watch now!
savethemanatee.org
January 3, 2025 at 2:44 PM
Here's a way to brighten up your Friday! The manatees are back in Florida for the winter and that means you get to watch them on live webcam feeds. savethemanatee.org/manatees/web...
Enjoy!
Enjoy!
Up for the sunrise this morning and it did not disappoint!
December 30, 2024 at 1:41 PM
Up for the sunrise this morning and it did not disappoint!
Working on our first attempt at ONE microscopy today. www.nature.com/articles/s41...
Very exciting!
Very exciting!
One-step nanoscale expansion microscopy reveals individual protein shapes - Nature Biotechnology
Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.
www.nature.com
November 21, 2024 at 7:53 PM
Working on our first attempt at ONE microscopy today. www.nature.com/articles/s41...
Very exciting!
Very exciting!
Fluorescence Friday huh? How about this wild spindle from Xenopus tissue culture cells? This was taken last week during out Cell Biology grad module.
I'll try posting a video in the comments to this post. I tried an animated gif already and it didn't seem to work.
I'll try posting a video in the comments to this post. I tried an animated gif already and it didn't seem to work.
November 15, 2024 at 3:30 PM
Fluorescence Friday huh? How about this wild spindle from Xenopus tissue culture cells? This was taken last week during out Cell Biology grad module.
I'll try posting a video in the comments to this post. I tried an animated gif already and it didn't seem to work.
I'll try posting a video in the comments to this post. I tried an animated gif already and it didn't seem to work.
Reposted by Jeff Lange
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
November 11, 2024 at 7:33 PM
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Gonna send this out there one more time since there are so many new people here. Any info would be appreciated!
Has anyone been to the American Physical Society's March meeting (now apparently called the APS Global Physics Summit) specifically looking for biophys content? How does it compare the Biophysical Society conference? Or how does it compare to other large meetings (ASCB, SFN, ?) you may have been to?
November 11, 2024 at 11:19 PM
Gonna send this out there one more time since there are so many new people here. Any info would be appreciated!
This is pretty epic!
November 10, 2024 at 2:11 AM
This is pretty epic!
Has anyone been to the American Physical Society's March meeting (now apparently called the APS Global Physics Summit) specifically looking for biophys content? How does it compare the Biophysical Society conference? Or how does it compare to other large meetings (ASCB, SFN, ?) you may have been to?
November 7, 2024 at 7:59 PM
Has anyone been to the American Physical Society's March meeting (now apparently called the APS Global Physics Summit) specifically looking for biophys content? How does it compare the Biophysical Society conference? Or how does it compare to other large meetings (ASCB, SFN, ?) you may have been to?