Juan Burrone
@jbneuro.bsky.social
Neuroscientist at King's College London
Reposted by Juan Burrone
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
October 4, 2025 at 2:16 AM
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
Reposted by Juan Burrone
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...
www.biorxiv.org
October 6, 2025 at 9:50 AM
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Juan Burrone
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Juan Burrone
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
rdcu.be
May 15, 2025 at 8:26 AM
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Reposted by Juan Burrone
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
April 30, 2025 at 3:12 PM
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
Reposted by Juan Burrone
Deadline for FENS/IBRO-PERC stipends for our summer course extended to March 05, 2025‼️
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
February 27, 2025 at 10:18 PM
Deadline for FENS/IBRO-PERC stipends for our summer course extended to March 05, 2025‼️
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
Reposted by Juan Burrone
Ever wondered how to share research data but didn’t know where to start? Join us for an informal and open workshop where we’ll break down the how and why of data sharing.
January 20, 2025 at 9:41 PM
Ever wondered how to share research data but didn’t know where to start? Join us for an informal and open workshop where we’ll break down the how and why of data sharing.
Delighted to see this out! A great story by @bcompans and @vimast86 with the help of @Lenherr_C. Nanoscale plasticity of axo-axonic synapses at the AIS. Enjoy!
Thank you @jbneuro.bsky.social for giving me the freedome to apply my fascination for super-resolution micrscopy to one of, if not his favorite compartment, the AIS.
A big thanks to Vincenzo for bringing his fantastic patching skills and to Clara for joining this adventure too!
A big thanks to Vincenzo for bringing his fantastic patching skills and to Clara for joining this adventure too!
December 2, 2024 at 9:12 PM
Delighted to see this out! A great story by @bcompans and @vimast86 with the help of @Lenherr_C. Nanoscale plasticity of axo-axonic synapses at the AIS. Enjoy!