Jarek Cendrowski
@jarekcendrowski.bsky.social
Senior postdoc interested in crosstalk between membrane trafficking and metabolism in the context of cell differentiation and cancer. Trying to do everything using HCS microscopy.
Reposted by Jarek Cendrowski
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
November 25, 2025 at 4:22 PM
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Reposted by Jarek Cendrowski
Reposted by Jarek Cendrowski
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 7:45 PM
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Reposted by Jarek Cendrowski
I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!
March 26, 2025 at 4:58 AM
I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!
Reposted by Jarek Cendrowski
Lovely to see the JCS best paper prize renamed in honor of David Stephens, a fantastic cell biologist the world lost far too soon #biologists100
March 26, 2025 at 11:10 AM
Lovely to see the JCS best paper prize renamed in honor of David Stephens, a fantastic cell biologist the world lost far too soon #biologists100
Reposted by Jarek Cendrowski
An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 28, 2025 at 7:13 PM
An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
Amazing science, with fantastic people at beautiful location of #EMBOcellBio24 Annaberg Workshop "From Molecules to Organisms".
March 21, 2025 at 10:24 AM
Amazing science, with fantastic people at beautiful location of #EMBOcellBio24 Annaberg Workshop "From Molecules to Organisms".
Reposted by Jarek Cendrowski
A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.
rdcu.be/ecb2B
Interesting section on unanswered questions.
rdcu.be/ecb2B
The pathways of secretory cargo export at the endoplasmic reticulum
Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...
rdcu.be
March 4, 2025 at 10:00 PM
A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.
rdcu.be/ecb2B
Interesting section on unanswered questions.
rdcu.be/ecb2B
Reposted by Jarek Cendrowski
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Reposted by Jarek Cendrowski
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications
Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...
www.nature.com
March 3, 2025 at 3:51 PM
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...