James Ware
@jamesware.bsky.social
Clinician Scientist. Cardiovascular genetics, genomics in healthcare, inherited cardiac conditions, open science, patient participation. He/him.
https://profiles.imperial.ac.uk/j.ware
https://profiles.imperial.ac.uk/j.ware
Reposted by James Ware
Last week we went to the Cardiomyopathy UK Midlands HCP Study Day to share what we’re doing with specialists from across the UK.
Thank you to everyone who has been helping us to open up research to more people, and to all the Heart Hivers who have given up their time to take part in research ❤
Thank you to everyone who has been helping us to open up research to more people, and to all the Heart Hivers who have given up their time to take part in research ❤
July 24, 2025 at 11:24 AM
Last week we went to the Cardiomyopathy UK Midlands HCP Study Day to share what we’re doing with specialists from across the UK.
Thank you to everyone who has been helping us to open up research to more people, and to all the Heart Hivers who have given up their time to take part in research ❤
Thank you to everyone who has been helping us to open up research to more people, and to all the Heart Hivers who have given up their time to take part in research ❤
Reposted by James Ware
🧬 New @emblebi.bsky.social service beta launched:
Perturbation Catalogue
🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies
Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...
Funded by @opentargets.org
Perturbation Catalogue
🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies
Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...
Funded by @opentargets.org
July 23, 2025 at 10:06 AM
🧬 New @emblebi.bsky.social service beta launched:
Perturbation Catalogue
🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies
Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...
Funded by @opentargets.org
Perturbation Catalogue
🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies
Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...
Funded by @opentargets.org
Reposted by James Ware
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
lms.mrc.ac.uk
July 9, 2025 at 3:19 PM
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
Reposted by James Ware
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.
#academicSky 🧪
www.nature.com/articles/d41...
#academicSky 🧪
www.nature.com/articles/d41...
Renewal of NIH grants linked to more innovative results, study finds
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.
www.nature.com
May 8, 2025 at 5:56 PM
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.
#academicSky 🧪
www.nature.com/articles/d41...
#academicSky 🧪
www.nature.com/articles/d41...
Reposted by James Ware
Our paper now published! 🙌🏻🧬🫀
@alexbutters25.bsky.social
@k-jt.bsky.social
@njhenden.bsky.social
@dgmacarthur.bsky.social
@kathrynmcgurk.bsky.social @jamesware.bsky.social @sharday-penn.bsky.social @rdbagnall.bsky.social @garvaninstitute.bsky.social @escardio.bsky.social
doi.org/10.1093/eurh...
@alexbutters25.bsky.social
@k-jt.bsky.social
@njhenden.bsky.social
@dgmacarthur.bsky.social
@kathrynmcgurk.bsky.social @jamesware.bsky.social @sharday-penn.bsky.social @rdbagnall.bsky.social @garvaninstitute.bsky.social @escardio.bsky.social
doi.org/10.1093/eurh...
A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets
Inherited cardiomyopathies, including hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathies affect ∼1 in 200–500 in the population. Gen
doi.org
April 17, 2025 at 3:46 AM
Reposted by James Ware
There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage!
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
Emerging Innovators Fellowship - MRC Laboratory of Medical Sciences
The Emerging Innovators Fellowship is a new 3-year fully-funded postdoctoral fellowship for scientists from Black Heritage Backgrounds.
lms.mrc.ac.uk
April 28, 2025 at 3:40 PM
There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage!
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply.
Applications close 11 May 2025.
Find out more 👇
Reposted by James Ware
🚨 New paper alert! 🚨
Using SHaRe registry data, we explored how clinical & genetic risk factors influence heart failure, arrhythmias, and mortality in men & women with HCM.
This study, from my PhD, emphasises the need for sex-specific approaches to improve care.
📖 Read more: bit.ly/41vlF9r
Using SHaRe registry data, we explored how clinical & genetic risk factors influence heart failure, arrhythmias, and mortality in men & women with HCM.
This study, from my PhD, emphasises the need for sex-specific approaches to improve care.
📖 Read more: bit.ly/41vlF9r
February 24, 2025 at 6:12 AM
🚨 New paper alert! 🚨
Using SHaRe registry data, we explored how clinical & genetic risk factors influence heart failure, arrhythmias, and mortality in men & women with HCM.
This study, from my PhD, emphasises the need for sex-specific approaches to improve care.
📖 Read more: bit.ly/41vlF9r
Using SHaRe registry data, we explored how clinical & genetic risk factors influence heart failure, arrhythmias, and mortality in men & women with HCM.
This study, from my PhD, emphasises the need for sex-specific approaches to improve care.
📖 Read more: bit.ly/41vlF9r
Reposted by James Ware
🚨Our double header on genetics of hypertrophic #cardiomyopathy out today in @naturegenet.bsky.social 🧬
📍GWAS www.nature.com/articles/s41...
📍polygenic scores www.nature.com/articles/s41...
A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel
📍GWAS www.nature.com/articles/s41...
📍polygenic scores www.nature.com/articles/s41...
A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel
www.nature.com
February 18, 2025 at 12:19 PM
🚨Our double header on genetics of hypertrophic #cardiomyopathy out today in @naturegenet.bsky.social 🧬
📍GWAS www.nature.com/articles/s41...
📍polygenic scores www.nature.com/articles/s41...
A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel
📍GWAS www.nature.com/articles/s41...
📍polygenic scores www.nature.com/articles/s41...
A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel
Reposted by James Ware
Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…
www.sciencedirect.com
February 18, 2025 at 6:14 AM
Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Reposted by James Ware
TWO STAR co-first authors did most of the heavy lifting on this: Sophie Hespe and Amber Waddell 🌟 🌟 And huge high five to our biocurators and experts @jamesware.bsky.social @roddywalsh.bsky.social @chloereuter.bsky.social @andrewlandstrom.bsky.social @anwarchahal.bsky.social +++
February 18, 2025 at 6:14 AM
TWO STAR co-first authors did most of the heavy lifting on this: Sophie Hespe and Amber Waddell 🌟 🌟 And huge high five to our biocurators and experts @jamesware.bsky.social @roddywalsh.bsky.social @chloereuter.bsky.social @andrewlandstrom.bsky.social @anwarchahal.bsky.social +++
Reposted by James Ware
We’re really excited to focus on understanding takotsubo cardiomyopathy. Have your say and take part in research to help us find the causes, risks, and treatments 💪🫀🧬 @thebhf.bsky.social
We want to learn more about the genetics of Takotsubo cardiomyopathy.
Are you over 18, in the UK and interested in taking part in research?
Go to thehearthive.org to learn more about the Heart Hive Cardiomyopathy Study.
#takotsubo #research #cardiomyopathy
Are you over 18, in the UK and interested in taking part in research?
Go to thehearthive.org to learn more about the Heart Hive Cardiomyopathy Study.
#takotsubo #research #cardiomyopathy
November 22, 2024 at 6:52 PM
We’re really excited to focus on understanding takotsubo cardiomyopathy. Have your say and take part in research to help us find the causes, risks, and treatments 💪🫀🧬 @thebhf.bsky.social
Reposted by James Ware
The long awaited European guidelines for the use of Polygenic score for primary prevention of cardiovascular diseases are out!
It took > 10 years from the first results proposing its use as additional screening factor among patients with intermediate CVD risk
academic.oup.com/eurheartj/ad...
It took > 10 years from the first results proposing its use as additional screening factor among patients with intermediate CVD risk
academic.oup.com/eurheartj/ad...
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular...
Abstract. Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (
academic.oup.com
February 7, 2025 at 5:02 AM
The long awaited European guidelines for the use of Polygenic score for primary prevention of cardiovascular diseases are out!
It took > 10 years from the first results proposing its use as additional screening factor among patients with intermediate CVD risk
academic.oup.com/eurheartj/ad...
It took > 10 years from the first results proposing its use as additional screening factor among patients with intermediate CVD risk
academic.oup.com/eurheartj/ad...
Reposted by James Ware
Most cardiac arrests happen at home, and knowing CPR could save the life of someone you love. All you need is your phone and a cushion to learn CPR in just 15 minutes, for free with RevivR. Be ready for when it matters most. ❤️ Find out more about RevivR here: bit.ly/3E7D0fg:
February 7, 2025 at 9:10 AM
Most cardiac arrests happen at home, and knowing CPR could save the life of someone you love. All you need is your phone and a cushion to learn CPR in just 15 minutes, for free with RevivR. Be ready for when it matters most. ❤️ Find out more about RevivR here: bit.ly/3E7D0fg:
Reposted by James Ware
February is #HeartMonth! Want to get involved in heart research but not sure how? The Heart Hive is an online portal where you can sign up to take part in research studies.
Go to thehearthive.org to find out more and register today.
#NationalHeartMonth #HeartResearch #ParticipateInResearch
Go to thehearthive.org to find out more and register today.
#NationalHeartMonth #HeartResearch #ParticipateInResearch
February 5, 2025 at 11:02 AM
February is #HeartMonth! Want to get involved in heart research but not sure how? The Heart Hive is an online portal where you can sign up to take part in research studies.
Go to thehearthive.org to find out more and register today.
#NationalHeartMonth #HeartResearch #ParticipateInResearch
Go to thehearthive.org to find out more and register today.
#NationalHeartMonth #HeartResearch #ParticipateInResearch
Reposted by James Ware
Fantastic to work with Emma, a patient-scientist with DCM, on this review informed by her perspective, please check it out!
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs | Cardiology in the Young | Cambridge Core
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs
www.cambridge.org
February 6, 2025 at 8:59 AM
Fantastic to work with Emma, a patient-scientist with DCM, on this review informed by her perspective, please check it out!
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Reposted by James Ware
🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal,
👉 gvascstudy.org 👈
👉 gvascstudy.org 👈
January 9, 2025 at 12:02 AM
🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal,
👉 gvascstudy.org 👈
👉 gvascstudy.org 👈
Reposted by James Ware
The prevalence for cardiomyopathies is also now displayed for genes associated with cardiac disorders @jamesware.bsky.social @kathrynmcgurk.bsky.social
January 8, 2025 at 4:03 PM
The prevalence for cardiomyopathies is also now displayed for genes associated with cardiac disorders @jamesware.bsky.social @kathrynmcgurk.bsky.social
Reposted by James Ware
Cardiac case/control cohort data, which demonstrates the confidence of cardiac gene-phenotype relationships associated with specific variant classes, has been updated; more variant classes e.g. canonical splice site variants @jamesware.bsky.social @kathrynmcgurk.bsky.social
January 8, 2025 at 4:03 PM
Cardiac case/control cohort data, which demonstrates the confidence of cardiac gene-phenotype relationships associated with specific variant classes, has been updated; more variant classes e.g. canonical splice site variants @jamesware.bsky.social @kathrynmcgurk.bsky.social
Reposted by James Ware
Estimated population penetrance for variants associated with cardiomyopathies are now displayed alongside cardiac allele frequencies. This information is useful when considering secondary findings @jamesware.bsky.social @kathrynmcgurk.bsky.social
January 8, 2025 at 4:03 PM
Estimated population penetrance for variants associated with cardiomyopathies are now displayed alongside cardiac allele frequencies. This information is useful when considering secondary findings @jamesware.bsky.social @kathrynmcgurk.bsky.social
Reposted by James Ware
DECIPHER version 11.29 has been released. See the new features at www.deciphergenomics.org #variantinterpretation
January 8, 2025 at 4:01 PM
DECIPHER version 11.29 has been released. See the new features at www.deciphergenomics.org #variantinterpretation
Reposted by James Ware
We’re hiring for Programme Leader Track positions! This is an outstanding opportunity to advance your career in a discovery science institute of world-leading excellence.
Application deadline is 13 January 2025.
lms.mrc.ac.uk/work/vacanci...
Application deadline is 13 January 2025.
lms.mrc.ac.uk/work/vacanci...
Programme Leader Track - MRC Laboratory of Medical Sciences
Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.
lms.mrc.ac.uk
January 6, 2025 at 3:50 PM
We’re hiring for Programme Leader Track positions! This is an outstanding opportunity to advance your career in a discovery science institute of world-leading excellence.
Application deadline is 13 January 2025.
lms.mrc.ac.uk/work/vacanci...
Application deadline is 13 January 2025.
lms.mrc.ac.uk/work/vacanci...
Are you a computational biologist, looking for a role in a diverse and collaborative team, and eager to help us understand genetic heart muscle diseases? Come and join us. Closing date 12th January...
Exciting new opportunity for a Postdoctoral Research Bioinformatician within our Cardiovascular Genomics and Precision Medicine Group at the MRC LMS and Imperial #bioinformatics #postdoc @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social
Apply now:
tinyurl.com/ypwz7uva
Apply now:
tinyurl.com/ypwz7uva
MRC Postdoctoral Research Scientist LMS 2530 - Medical Research Council
Location: London. Vacancy: MRC Postdoctoral Research Scientist LMS 2530. Closing Date: 12/01/2025, 23:55
tinyurl.com
January 8, 2025 at 3:11 PM
Are you a computational biologist, looking for a role in a diverse and collaborative team, and eager to help us understand genetic heart muscle diseases? Come and join us. Closing date 12th January...
Reposted by James Ware
Check out our @mrc-lms.bsky.social Programme Leader Track opportunities - open for Submission of applications until 13/01/2025, interviews for shortlisted candidates in March lms.mrc.ac.uk/wp-content/u... #scisky #medsky
December 24, 2024 at 8:03 AM
Check out our @mrc-lms.bsky.social Programme Leader Track opportunities - open for Submission of applications until 13/01/2025, interviews for shortlisted candidates in March lms.mrc.ac.uk/wp-content/u... #scisky #medsky
Reposted by James Ware
We’re delighted to share our recruitment brochure for our current Programme Leader Track vacancies at the MRC Laboratory of Medical Sciences.
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
Programme Leader Track - MRC Laboratory of Medical Sciences
Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.
lms.mrc.ac.uk
December 17, 2024 at 4:14 PM
We’re delighted to share our recruitment brochure for our current Programme Leader Track vacancies at the MRC Laboratory of Medical Sciences.
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
You can download the brochure on our vacancy web page 👇
lms.mrc.ac.uk/work/vacanci...
Fantastic opportunity of funded research position for clinician scientists in training (predoctoral fellowships). Come and see why the LMS is a fun and rewarding place to do science...
December 10, 2024 at 5:40 PM
Fantastic opportunity of funded research position for clinician scientists in training (predoctoral fellowships). Come and see why the LMS is a fun and rewarding place to do science...