James Forward
@jamesforward.bsky.social
Fundamental Cell Biology and Neuroscience at UCSF. Formerly Microbial Evolution at UBC. https://jcforward.github.io/
Reposted by James Forward
We have a new preprint!
👉 We’ve developed a novel method to induce spindle buckling and utilize this deformation to gain insights into their structural integrity.
👉 A little animated illustration on the bent spindles (green) and our model (blue+pink) where we tune the rigidity of the midzone.
👉 We’ve developed a novel method to induce spindle buckling and utilize this deformation to gain insights into their structural integrity.
👉 A little animated illustration on the bent spindles (green) and our model (blue+pink) where we tune the rigidity of the midzone.
November 25, 2025 at 5:09 AM
We have a new preprint!
👉 We’ve developed a novel method to induce spindle buckling and utilize this deformation to gain insights into their structural integrity.
👉 A little animated illustration on the bent spindles (green) and our model (blue+pink) where we tune the rigidity of the midzone.
👉 We’ve developed a novel method to induce spindle buckling and utilize this deformation to gain insights into their structural integrity.
👉 A little animated illustration on the bent spindles (green) and our model (blue+pink) where we tune the rigidity of the midzone.
Reposted by James Forward
The second by @kevinguttenplan.bsky.social
in Marc Freeman's lab on gating of astrocyte responses to many transmitters by tyramine (an invertebrate norepinephrine analog) in flies, building on earlier work from the lab on astrocytes and ATP in larval fly behavior. science.org/doi/10.1126/... 4/8
in Marc Freeman's lab on gating of astrocyte responses to many transmitters by tyramine (an invertebrate norepinephrine analog) in flies, building on earlier work from the lab on astrocytes and ATP in larval fly behavior. science.org/doi/10.1126/... 4/8
GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity
How astrocytes regulate neuronal circuits is a fundamental question in neurobiology. Specifically, how astrocytes respond to different neurotransmitters in vivo and how they affect downstream circuit ...
science.org
May 16, 2025 at 4:20 AM
The second by @kevinguttenplan.bsky.social
in Marc Freeman's lab on gating of astrocyte responses to many transmitters by tyramine (an invertebrate norepinephrine analog) in flies, building on earlier work from the lab on astrocytes and ATP in larval fly behavior. science.org/doi/10.1126/... 4/8
in Marc Freeman's lab on gating of astrocyte responses to many transmitters by tyramine (an invertebrate norepinephrine analog) in flies, building on earlier work from the lab on astrocytes and ATP in larval fly behavior. science.org/doi/10.1126/... 4/8
Reposted by James Forward
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...
🔭 The Einstein AI model
I shared a controversial take the other day at an event and I decided to write it down in a longer format: I’m afraid AI won't give us a compressed 21st century.
thomwolf.io
March 22, 2025 at 4:06 PM
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...
Reposted by James Forward
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...
(1/n) www.biorxiv.org/content/earl...
Intracellular competition shapes plasmid population dynamics
Conflicts between levels of biological organization are central to evolution, from populations of multicellular organisms to selfish genetic elements in microbes. Plasmids are extrachromosomal, self-r...
www.biorxiv.org
February 21, 2025 at 8:36 PM
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...
(1/n) www.biorxiv.org/content/earl...
Reposted by James Forward
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:30 AM
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫