Jaakko Lehtimäki
@jalehtimaki.bsky.social
Currently post-doc @CellMigrationLab, previously @NordenLab. PhD from @LabLappalainen. Fascinated by cells on the move, zebrafish and boulders.
But not right away at least. And they do not seems to be too unhappy even when stuck with them😉
July 25, 2025 at 11:22 AM
But not right away at least. And they do not seems to be too unhappy even when stuck with them😉
Repulsive and attractive cues team up to sculpt the retina🔧👁️, Perfect positioning also for your neurons navigating in multipolar manner, no GPS required! Get your free pdf copy of the full story today: www.biorxiv.org/cgi/content/...
July 25, 2025 at 5:46 AM
Repulsive and attractive cues team up to sculpt the retina🔧👁️, Perfect positioning also for your neurons navigating in multipolar manner, no GPS required! Get your free pdf copy of the full story today: www.biorxiv.org/cgi/content/...
2. Attraction through Gfrα1 receptor (HC) and Neurturin secreted from apical photoreceptors.
-Weaker cue ensuring HCs reach the photoreceptors. Take both Neurturin and Robo2 out and majority of HCs (cyan + yellow) are misplaced in the amacrine cell layer (yellow).
-Weaker cue ensuring HCs reach the photoreceptors. Take both Neurturin and Robo2 out and majority of HCs (cyan + yellow) are misplaced in the amacrine cell layer (yellow).
July 25, 2025 at 5:46 AM
2. Attraction through Gfrα1 receptor (HC) and Neurturin secreted from apical photoreceptors.
-Weaker cue ensuring HCs reach the photoreceptors. Take both Neurturin and Robo2 out and majority of HCs (cyan + yellow) are misplaced in the amacrine cell layer (yellow).
-Weaker cue ensuring HCs reach the photoreceptors. Take both Neurturin and Robo2 out and majority of HCs (cyan + yellow) are misplaced in the amacrine cell layer (yellow).
1. Repulsion through Robo2 receptor (HC) and Slit1b/2, expressed by the basal amacrine cells (yellow).
-Without Robo2 HCs (cyan + yellow), especially the ones further away from photoreceptor cell layer (grey arrowheads), fail to laminate correctly.
-Without Robo2 HCs (cyan + yellow), especially the ones further away from photoreceptor cell layer (grey arrowheads), fail to laminate correctly.
July 25, 2025 at 5:46 AM
1. Repulsion through Robo2 receptor (HC) and Slit1b/2, expressed by the basal amacrine cells (yellow).
-Without Robo2 HCs (cyan + yellow), especially the ones further away from photoreceptor cell layer (grey arrowheads), fail to laminate correctly.
-Without Robo2 HCs (cyan + yellow), especially the ones further away from photoreceptor cell layer (grey arrowheads), fail to laminate correctly.
So, what is going on? 🤔 Using transcriptomics, in vivo CRISPR screens and high-res live imaging in a transparent zebrafish retina 👁️, we now introduce “The Spatiotemporal Guidance System🗺️⏰” for multipolar migration with dual action:
July 25, 2025 at 5:46 AM
So, what is going on? 🤔 Using transcriptomics, in vivo CRISPR screens and high-res live imaging in a transparent zebrafish retina 👁️, we now introduce “The Spatiotemporal Guidance System🗺️⏰” for multipolar migration with dual action:
But how then to know where to go? A problem many developing neurons face, including the retinal horizontal cells (HCs), we studied.
Neighboring cells as tracks? Removing 3/4 retinal cell types and HCs still navigate correctly. However, take out the 4th type (amacrine cells) and 💥 HCs are stuck.
Neighboring cells as tracks? Removing 3/4 retinal cell types and HCs still navigate correctly. However, take out the 4th type (amacrine cells) and 💥 HCs are stuck.
July 25, 2025 at 5:46 AM
But how then to know where to go? A problem many developing neurons face, including the retinal horizontal cells (HCs), we studied.
Neighboring cells as tracks? Removing 3/4 retinal cell types and HCs still navigate correctly. However, take out the 4th type (amacrine cells) and 💥 HCs are stuck.
Neighboring cells as tracks? Removing 3/4 retinal cell types and HCs still navigate correctly. However, take out the 4th type (amacrine cells) and 💥 HCs are stuck.
Also thrilled to start today a new chapter in @guijacquemet.bsky.social lab on microglia migration and their protrusion dynamics🧠🐠
January 7, 2025 at 11:15 AM
Also thrilled to start today a new chapter in @guijacquemet.bsky.social lab on microglia migration and their protrusion dynamics🧠🐠