Jaakko Lehtimäki
@jalehtimaki.bsky.social
Currently post-doc @CellMigrationLab, previously @NordenLab. PhD from @LabLappalainen. Fascinated by cells on the move, zebrafish and boulders.
Reposted by Jaakko Lehtimäki
Now online! Zebrafish use spectral information to suppress the visual background
Zebrafish use spectral information to suppress the visual background
Vertebrate eyes first evolved in water, where spectral content rapidly fades with distance. Zebrafish exploit this loss by antagonizing cone signals to suppress the background, pointing to distance estimation—rather than color—as an ancestral cone function.
dlvr.it
November 3, 2025 at 3:59 PM
Now online! Zebrafish use spectral information to suppress the visual background
Mind-boggling. Remember seeing older papers on playing music to cultured cell lines. Would love to see the reviewer responses on this one.
"Here we show that heartbeat sound promotes structural and functional maturation of human cortical organoids with a physiological astrocyte-to-neuron ratio." 🤯 www.biorxiv.org/content/10.1...
Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids
Heartbeat sound is one of the first rhythmic stimuli encountered by the developing human brain, yet its biological role has remained unexplored. Here we show that heartbeat sound promotes structural a...
www.biorxiv.org
October 24, 2025 at 11:44 AM
Mind-boggling. Remember seeing older papers on playing music to cultured cell lines. Would love to see the reviewer responses on this one.
Reposted by Jaakko Lehtimäki
Eric Peterman @errricpeterman.bsky.social, Jeffrey Rasmussen @jraslab.bsky.social @uwbiology.bsky.social & colleagues discover that microtubules regulate tissue-level navigation in skin-resident macrophages.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
September 24, 2025 at 8:13 AM
Eric Peterman @errricpeterman.bsky.social, Jeffrey Rasmussen @jraslab.bsky.social @uwbiology.bsky.social & colleagues discover that microtubules regulate tissue-level navigation in skin-resident macrophages.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Reposted by Jaakko Lehtimäki
Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:
September 6, 2025 at 11:09 PM
Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:
Reposted by Jaakko Lehtimäki
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
August 28, 2025 at 3:15 PM
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Had thought to test this wild idea in the future but so cool to see Francesca Peri lab making it real: Xenografted human microglia in zebrafish, doing their job 😍https://www.biorxiv.org/content/10.1101/2025.08.27.672578v1.full.pdf
www.biorxiv.org
August 28, 2025 at 6:47 AM
Had thought to test this wild idea in the future but so cool to see Francesca Peri lab making it real: Xenografted human microglia in zebrafish, doing their job 😍https://www.biorxiv.org/content/10.1101/2025.08.27.672578v1.full.pdf
Reposted by Jaakko Lehtimäki
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
August 18, 2025 at 5:07 PM
🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio
Interested in cell migration yet bored of the canonical translocation modes? 😴 Don’t worry — we @nordenlab.bsky.social with @aiopticalbiolab.bsky.social have multipolar migration back in stock! No need to follow the other cells: extend long protrusions and roam more freely🪼 in the crowded brain.
July 25, 2025 at 5:46 AM
Interested in cell migration yet bored of the canonical translocation modes? 😴 Don’t worry — we @nordenlab.bsky.social with @aiopticalbiolab.bsky.social have multipolar migration back in stock! No need to follow the other cells: extend long protrusions and roam more freely🪼 in the crowded brain.
Reposted by Jaakko Lehtimäki
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
June 23, 2025 at 2:29 PM
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
Skimming through biorxiv might improve your climbing?
As a non-expert (climber and in this field), I was taught to climb the route mentally before physically. Movement coordination comes through repetitions as in any sport.🤔
As a non-expert (climber and in this field), I was taught to climb the route mentally before physically. Movement coordination comes through repetitions as in any sport.🤔
Whole-body coarticulation reflects expertise in sport climbing
Taking sport climbing as a testbed, we explored coarticulation in naturalistic motor-behavior at the level of whole-body kinematics. Participants were instructed to execute a series of climbing routes...
www.biorxiv.org
January 14, 2025 at 6:27 AM
Skimming through biorxiv might improve your climbing?
As a non-expert (climber and in this field), I was taught to climb the route mentally before physically. Movement coordination comes through repetitions as in any sport.🤔
As a non-expert (climber and in this field), I was taught to climb the route mentally before physically. Movement coordination comes through repetitions as in any sport.🤔
Reposted by Jaakko Lehtimäki
Ever wondered how to manipulate mechanical forces in the developing zebrafish heart?🤓
Check out our new protocol by @cvagenapantoula.bsky.social and Hajime, where we describe magnetic bead grafting as an effective approach to study #mechanotransduction!🐟🔬
app.jove.com/t/67604/mani...
Check out our new protocol by @cvagenapantoula.bsky.social and Hajime, where we describe magnetic bead grafting as an effective approach to study #mechanotransduction!🐟🔬
app.jove.com/t/67604/mani...
January 9, 2025 at 3:18 PM
Ever wondered how to manipulate mechanical forces in the developing zebrafish heart?🤓
Check out our new protocol by @cvagenapantoula.bsky.social and Hajime, where we describe magnetic bead grafting as an effective approach to study #mechanotransduction!🐟🔬
app.jove.com/t/67604/mani...
Check out our new protocol by @cvagenapantoula.bsky.social and Hajime, where we describe magnetic bead grafting as an effective approach to study #mechanotransduction!🐟🔬
app.jove.com/t/67604/mani...
After ~3.5 inspiring years @nordenlab.bsky.social, I’ve migrated back to 'apical' Finland. The last months, I appeared a lot like these multipolar retinal cells. Excited to share more soon about their fascinating in vivo navigation!
January 7, 2025 at 11:11 AM
After ~3.5 inspiring years @nordenlab.bsky.social, I’ve migrated back to 'apical' Finland. The last months, I appeared a lot like these multipolar retinal cells. Excited to share more soon about their fascinating in vivo navigation!