Bhawik Jain
@jainbhawik.bsky.social
Cell and Molecular Biologist, Cricket enthusiast
Reposted by Bhawik Jain
🍨Interested in reading more about the study? Here is the N&Vs article written by Michael Salsaa & Gregory D. Fairn.
👉https://rdcu.be/eADFu
bit.ly/45zxHiL
👉https://rdcu.be/eADFu
bit.ly/45zxHiL
Phosphoinositide flipping governs neomycin sensitivity - Nature Cell Biology
Neomycin toxicity in eukaryotic cells stems from its binding to phosphoinositides, primarily confined to the inner leaflet of the plasma membrane. New research reveals a complex lipid-trafficking path...
bit.ly
August 13, 2025 at 8:05 PM
🍨Interested in reading more about the study? Here is the N&Vs article written by Michael Salsaa & Gregory D. Fairn.
👉https://rdcu.be/eADFu
bit.ly/45zxHiL
👉https://rdcu.be/eADFu
bit.ly/45zxHiL
@vai.org @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social
#flippase #membrane-transport #neomycin #lipid transport
#flippase #membrane-transport #neomycin #lipid transport
July 14, 2025 at 7:28 PM
Our study explains why yeast cells lacking Neo1 are neomycin sensitive, which targets PI4P when it is exposed on the outer leaflet of the plasma membrane. We show that Neo1 flips PI4P, offering key mechanistic insight into how phosphoinositide membrane asymmetry is maintained. @vuartsci.bsky.social
July 14, 2025 at 7:28 PM
Our study explains why yeast cells lacking Neo1 are neomycin sensitive, which targets PI4P when it is exposed on the outer leaflet of the plasma membrane. We show that Neo1 flips PI4P, offering key mechanistic insight into how phosphoinositide membrane asymmetry is maintained. @vuartsci.bsky.social