close to heaven, could only be better with tartine bread

Noam is a hero. It’s a shame there are no good books about him. “Man who fed the world” doesn’t do him justice.

thanks for sharing, reached out :)

this is gorgeous! any trick to spotting these events?

would love to meet while you’re in town

for hotels, South SF is probably a good 80/20. mostly oriented toward biotech travelers & ~15’ from downtown.

the Sound Life Cohort from Allen Immunology has 100+ patients for PBMCs.

Unfortunately I don’t think there are any multi-tissue unified efforts at that scale yet, so the best data available today might need to integrate across studies.

zenodo wrapped: which supplemental methods did you most rely upon 🙂

excited to dig into this, congratulations to the team 🎉

we remodeled also @newlimitbio.bsky.social hq.

we stole design ideas from bell labs & skunk works, then added glass everywhere to mimic the future we're trying to build.

we're all excited for the discoveries to come in our new space.

we've previously discovered TF sets that reverse T cell age using a phenotypic approach. for each TF set, we ask if it makes old T cells "look" younger based on gene expression.

last month, we developed our 1st functional screening system that directly measures the impact of 100s of TF sets at once

discovering TF sets that reverse cell age is only the first step to making a medicine. next, we'll need to formulate these TF sets into drugs.

@newlimitbio.bsky.social is leveraging LNP-mRNA technology to achieve this, similar to the COVID vaccines.

our Metabolism team developed 2 gold-standard pre-clinical models for hepatocytes.

consistent with our previous results, old hepatocytes are more susceptible to damage than young in both settings.

We've ported our Engine technology to human hepatocytes and received our first in vivo screening results

to our knowledge, these are the first in vivo screening data for human hepatocytes & the first 70 reprogramming sets tested to date. already we're seeing promising signals.

jacob let’s be honest we all know you mostly use fruits