Jacob Kimmel
jacobkimmel.bsky.social
Jacob Kimmel
@jacobkimmel.bsky.social
co-founder & president @newlimitbio.bsky.social | Prev PI @calico, PhD @ucsf | interested in aging, machine learning, genomics, & the technology production function

https://jck.bio
we remodeled also @newlimitbio.bsky.social hq.

we stole design ideas from bell labs & skunk works, then added glass everywhere to mimic the future we're trying to build.

we're all excited for the discoveries to come in our new space.
November 23, 2024 at 6:16 PM
discovering TF sets that reverse cell age is only the first step to making a medicine. next, we'll need to formulate these TF sets into drugs.

@newlimitbio.bsky.social is leveraging LNP-mRNA technology to achieve this, similar to the COVID vaccines.
November 23, 2024 at 6:16 PM
our Metabolism team developed 2 gold-standard pre-clinical models for hepatocytes.

consistent with our previous results, old hepatocytes are more susceptible to damage than young in both settings.
November 23, 2024 at 6:16 PM
We've ported our Engine technology to human hepatocytes and received our first in vivo screening results

to our knowledge, these are the first in vivo screening data for human hepatocytes & the first 70 reprogramming sets tested to date. already we're seeing promising signals.
November 23, 2024 at 6:16 PM