Jacob Kimmel
@jacobkimmel.bsky.social
co-founder & president @newlimitbio.bsky.social | Prev PI @calico, PhD @ucsf | interested in aging, machine learning, genomics, & the technology production function
https://jck.bio
https://jck.bio
we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease.
now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.
it's a privilege to build this future with generational partners.
now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.
it's a privilege to build this future with generational partners.
NewLimit has raised a $130M Series B led by Kleiner Perkins alongside NFDG, @khoslaventures.bsky.social, Human Capital and returning investors Dimension & Founders Fund
We're grateful for their boldness in joining us on our journey to extend human healthspan
blog.newlimit.com/p/newlimit-r...
We're grateful for their boldness in joining us on our journey to extend human healthspan
blog.newlimit.com/p/newlimit-r...
NewLimit raises $130 million Series B led by Kleiner Perkins alongside NFDG, Khosla Ventures, Human Capital and others
NewLimit is developing medicines to extend human healthspan through epigenetic reprogramming
blog.newlimit.com
May 6, 2025 at 9:56 PM
we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease.
now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.
it's a privilege to build this future with generational partners.
now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.
it's a privilege to build this future with generational partners.
health is both the most valuable commodity & a Jevons good.
the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.
the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.
May 4, 2025 at 8:53 PM
health is both the most valuable commodity & a Jevons good.
the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.
the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.
AI2's paper finder is one of the best improvements to my research workflow in years
highly recommended:
highly recommended:
Introducing Ai2 Paper Finder | Ai2
Ai2 Paper Finder is an LLM-powered literature search system that mimics the iterative paper-finding process.
allenai.org
April 5, 2025 at 6:03 PM
AI2's paper finder is one of the best improvements to my research workflow in years
highly recommended:
highly recommended:
each year @newlimitbio.bsky.social, we share an update on our progress with the public
this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.
watch here: m.youtube.com/watch?v=HR0-...
this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.
watch here: m.youtube.com/watch?v=HR0-...
NewLimit Progress Update 2025
YouTube video by NewLimit
m.youtube.com
March 23, 2025 at 6:07 AM
each year @newlimitbio.bsky.social, we share an update on our progress with the public
this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.
watch here: m.youtube.com/watch?v=HR0-...
this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.
watch here: m.youtube.com/watch?v=HR0-...
early winter @newlimitbio.bsky.social:
- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline
details: bit.ly/4iuBvqC
- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline
details: bit.ly/4iuBvqC
January // February 2025 Progress Update
Therapeutic beginnings
blog.newlimit.com
March 14, 2025 at 4:23 PM
early winter @newlimitbio.bsky.social:
- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline
details: bit.ly/4iuBvqC
- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline
details: bit.ly/4iuBvqC
cognitive drills are substantially underrated in molecular biology & genomics
half of creativity is having the ingredients for invention top of mind
building a Borgesian mental library of enzymes & reactions pays dividends
half of creativity is having the ingredients for invention top of mind
building a Borgesian mental library of enzymes & reactions pays dividends
March 1, 2025 at 8:36 PM
cognitive drills are substantially underrated in molecular biology & genomics
half of creativity is having the ingredients for invention top of mind
building a Borgesian mental library of enzymes & reactions pays dividends
half of creativity is having the ingredients for invention top of mind
building a Borgesian mental library of enzymes & reactions pays dividends
2024 @newlimitbio.bsky.social:
- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming
we demonstrated that reprogramming medicines are possible
2025: we start to develop them
bit.ly/4h7rrD3
- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming
we demonstrated that reprogramming medicines are possible
2025: we start to develop them
bit.ly/4h7rrD3
2024 Year in Review
Restoring youthful function
bit.ly
January 9, 2025 at 5:12 PM
2024 @newlimitbio.bsky.social:
- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming
we demonstrated that reprogramming medicines are possible
2025: we start to develop them
bit.ly/4h7rrD3
- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming
we demonstrated that reprogramming medicines are possible
2025: we start to develop them
bit.ly/4h7rrD3
Reposted by Jacob Kimmel
Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction.
www.nature.com/articles/s41... 1/
www.nature.com/articles/s41... 1/
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics
Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.
www.nature.com
January 8, 2025 at 10:06 PM
Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction.
www.nature.com/articles/s41... 1/
www.nature.com/articles/s41... 1/
obesity installs an epigenetic memory that persists even after weight loss
this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient
imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time
this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient
imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 27, 2024 at 7:59 AM
obesity installs an epigenetic memory that persists even after weight loss
this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient
imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time
this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient
imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time
early autumn @newlimitbio.bsky.social:
- 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system
- +2779 TF sets tested in T cells
- +51 sets that reverse phenotypic age in T cells
- 5 → 7 functional assays for hepatocyte age
- 0 → 80% efficiency LNP-mRNA delivery
bit.ly/4g0NKJV
- 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system
- +2779 TF sets tested in T cells
- +51 sets that reverse phenotypic age in T cells
- 5 → 7 functional assays for hepatocyte age
- 0 → 80% efficiency LNP-mRNA delivery
bit.ly/4g0NKJV
September // October 2024 Progress Update
In chimerico reprogramming
blog.newlimit.com
November 23, 2024 at 6:16 PM
early autumn @newlimitbio.bsky.social:
- 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system
- +2779 TF sets tested in T cells
- +51 sets that reverse phenotypic age in T cells
- 5 → 7 functional assays for hepatocyte age
- 0 → 80% efficiency LNP-mRNA delivery
bit.ly/4g0NKJV
- 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system
- +2779 TF sets tested in T cells
- +51 sets that reverse phenotypic age in T cells
- 5 → 7 functional assays for hepatocyte age
- 0 → 80% efficiency LNP-mRNA delivery
bit.ly/4g0NKJV
late summer @newlimit
- world's largest partial reprogramming screen (again)
- 3x'd speed of sequencing turn-around
- 5x'd reprog factor library size
- built our first integrated reprog corpus for model training
- team += 3
blog.newlimit.com/p/july-augus...
- world's largest partial reprogramming screen (again)
- 3x'd speed of sequencing turn-around
- 5x'd reprog factor library size
- built our first integrated reprog corpus for model training
- team += 3
blog.newlimit.com/p/july-augus...
July-August 2023 Progress Update
Recursive record setting
blog.newlimit.com
September 9, 2023 at 5:09 PM
late summer @newlimit
- world's largest partial reprogramming screen (again)
- 3x'd speed of sequencing turn-around
- 5x'd reprog factor library size
- built our first integrated reprog corpus for model training
- team += 3
blog.newlimit.com/p/july-augus...
- world's largest partial reprogramming screen (again)
- 3x'd speed of sequencing turn-around
- 5x'd reprog factor library size
- built our first integrated reprog corpus for model training
- team += 3
blog.newlimit.com/p/july-augus...