The 6th Sunrise Meeting

The 2025 MRS Early Career Research Virtual Meeting is a two day meeting aimed at engaging trainees and early career researchers from around the world and highlighting recent advances in metastasis research through keynote presentations, invited talks, panel discussions, and selected talks from abstracts. The meeting is organized and hosted by the Early Career Leadership Council (ECLC) of the MRS. Abstracts are being accepted for consideration for oral presentations. Abstract submission is open to graduate students, postdoctoral fellows, medical students, residents, clinical fellows, and researchers within 3 years of starting their own independent research group. Registration for this meeting is free for MRS Members!

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Daniel Kirschenbaum has developed an experimental method for investigating immune responses in living organisms with high temporal resolution. The technique enabled him and his colleagues to reconstru...

Nature Reviews Clinical Oncology, Published online: 27 October 2025; doi:10.1038/s41571-025-01090-2Sacituzumab tirumotecan improves OS in EGFR TKI-resistant NSCLC

Zhong et al. report that SHR-A1921, a novel TROP-2-targeted antibody-drug conjugate, demonstrates promising efficacy and a tolerable safety profile in heavily pretreated advanced or metastatic solid tumors, notably ovarian, lung, and breast cancers. Its favorable safety profile with reduced bone marrow toxicity supports its potential for future combination therapy strategies.

Antibody-drug conjugate cut risk for death by 40% versus platinum-based chemotherapy

Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the molecular interactions and immune system effects of these sophisticated drugs that drive their efficacy and toxicity.

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

YouTube video by CRUK Manchester Institute