Javier Gonzalez
@j-t-gonzalez.bsky.social
Scientist
Nutrition and Metabolism
Energy, Carbohydrate and Fat Metabolism
University of Bath, UK
https://researchportal.bath.ac.uk/en/persons/javier-gonzalez
https://gonzalezjt1.wordpress.com/2024/03/
Nutrition and Metabolism
Energy, Carbohydrate and Fat Metabolism
University of Bath, UK
https://researchportal.bath.ac.uk/en/persons/javier-gonzalez
https://gonzalezjt1.wordpress.com/2024/03/
New paper from
@CNEM_Bath
in
@JPhysiol
led by
@lfbradshaw
Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling
doi.org/10.1113/JP28...
(1/7)
#exercise #metabolism #muscle #fasting
@CNEM_Bath
in
@JPhysiol
led by
@lfbradshaw
Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling
doi.org/10.1113/JP28...
(1/7)
#exercise #metabolism #muscle #fasting
November 17, 2025 at 7:15 AM
New paper from
@CNEM_Bath
in
@JPhysiol
led by
@lfbradshaw
Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling
doi.org/10.1113/JP28...
(1/7)
#exercise #metabolism #muscle #fasting
@CNEM_Bath
in
@JPhysiol
led by
@lfbradshaw
Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling
doi.org/10.1113/JP28...
(1/7)
#exercise #metabolism #muscle #fasting
Reposted by Javier Gonzalez
Born #OnThisDay in 1934 was astronomer, astrobiologist and science communicator Carl Sagan. As well as being one of the world's greatest science communicators, he worked on the Viking and Mariner missions. Listen to his famous 'Pale Blue Dot' monologue: https://bit.ly/2ANRX30
November 9, 2025 at 11:00 AM
Born #OnThisDay in 1934 was astronomer, astrobiologist and science communicator Carl Sagan. As well as being one of the world's greatest science communicators, he worked on the Viking and Mariner missions. Listen to his famous 'Pale Blue Dot' monologue: https://bit.ly/2ANRX30
Reposted by Javier Gonzalez
You categorised patients as responders or non responders by dichotomising a change from baseline?
You triple criminal!
You triple criminal!
November 8, 2025 at 7:33 PM
You categorised patients as responders or non responders by dichotomising a change from baseline?
You triple criminal!
You triple criminal!
Reposted by Javier Gonzalez
Stop interpreting clinical trials as if they were surveys.
www.linkedin.com/pulse/illegi...
www.linkedin.com/pulse/illegi...
Illegible Eligible
Several times recently, in published papers and in papers I have been asked to review, I have come across the quite incorrect claim that the eligibility criteria of a clinical trial define the target ...
www.linkedin.com
November 2, 2025 at 10:50 AM
Stop interpreting clinical trials as if they were surveys.
www.linkedin.com/pulse/illegi...
www.linkedin.com/pulse/illegi...
Reposted by Javier Gonzalez
The target population for the research question is the population of people who would satisfy the eligibility criteria. “
Wrong x 2
1) The eligibility criteria define who doesn’t come into the trial not who does.
2) We generalise from quite different trials to populations eg bioequivalence trials.
Wrong x 2
1) The eligibility criteria define who doesn’t come into the trial not who does.
2) We generalise from quite different trials to populations eg bioequivalence trials.
November 1, 2025 at 7:03 PM
The target population for the research question is the population of people who would satisfy the eligibility criteria. “
Wrong x 2
1) The eligibility criteria define who doesn’t come into the trial not who does.
2) We generalise from quite different trials to populations eg bioequivalence trials.
Wrong x 2
1) The eligibility criteria define who doesn’t come into the trial not who does.
2) We generalise from quite different trials to populations eg bioequivalence trials.
Reposted by Javier Gonzalez
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
October 24, 2025 at 8:43 PM
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China.
My slides can be viewed here:
www.linkedin.com/posts/javier...
My slides can be viewed here:
www.linkedin.com/posts/javier...
RACMEM Debate: Is Human Energy Expenditure Constrained? | Javier Gonzalez
Is human energy expenditure constrained?
This hypothesis was proposed by Herman Pontzer, and has received widespread interest with coverage from mainstream media, podcasts, and even the RI Christmas ...
www.linkedin.com
October 19, 2025 at 12:13 PM
Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China.
My slides can be viewed here:
www.linkedin.com/posts/javier...
My slides can be viewed here:
www.linkedin.com/posts/javier...
Reposted by Javier Gonzalez
Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...
Erroneous epidemiological findings on vitamins: coming full circle after two decades of Mendelian randomization?
Our editorial responsibility for the International Journal of Epidemiology (IJE) started at the dawn of the current millennium, and we marked the occasion
academic.oup.com
September 11, 2025 at 1:47 PM
Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...
Reposted by Javier Gonzalez
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
journals.humankinetics.com
August 28, 2025 at 5:50 PM
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
Reposted by Javier Gonzalez
New insights into glycogen recovery in endurance athletes 🧵
1️⃣ Our new study in The Journal of Physiology tested how muscle + liver glycogen recover after exhaustive cycling in well-trained cyclists.
1️⃣ Our new study in The Journal of Physiology tested how muscle + liver glycogen recover after exhaustive cycling in well-trained cyclists.
August 21, 2025 at 7:22 AM
New insights into glycogen recovery in endurance athletes 🧵
1️⃣ Our new study in The Journal of Physiology tested how muscle + liver glycogen recover after exhaustive cycling in well-trained cyclists.
1️⃣ Our new study in The Journal of Physiology tested how muscle + liver glycogen recover after exhaustive cycling in well-trained cyclists.
Reposted by Javier Gonzalez
The ideal, of course, is to have randomisation embedded into routine practice … then, the real world data of the future will be randomised data giving the best of both worlds 9/9
August 18, 2025 at 6:35 AM
The ideal, of course, is to have randomisation embedded into routine practice … then, the real world data of the future will be randomised data giving the best of both worlds 9/9
Reposted by Javier Gonzalez
There has been a lot of debate recently about the promise of real world data - the routine (observational) data collected on patients eg treatments received, clinical outcomes etc – for estimating treatment effects. But can they deliver? 1/9
#MethodologyMonday #123
#MethodologyMonday #123
August 18, 2025 at 6:35 AM
There has been a lot of debate recently about the promise of real world data - the routine (observational) data collected on patients eg treatments received, clinical outcomes etc – for estimating treatment effects. But can they deliver? 1/9
#MethodologyMonday #123
#MethodologyMonday #123
New paper!
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
August 12, 2025 at 5:26 PM
New paper!
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
🚨 3-year Post-doc opportunity at the Centre for Nutrition, Exercise and Metabolism
Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets
www.bath.ac.uk/jobs/Vacancy...
Building in our prior work
pubmed.ncbi.nlm.nih.gov/39106867/
Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets
www.bath.ac.uk/jobs/Vacancy...
Building in our prior work
pubmed.ncbi.nlm.nih.gov/39106867/
August 3, 2025 at 8:04 AM
🚨 3-year Post-doc opportunity at the Centre for Nutrition, Exercise and Metabolism
Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets
www.bath.ac.uk/jobs/Vacancy...
Building in our prior work
pubmed.ncbi.nlm.nih.gov/39106867/
Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets
www.bath.ac.uk/jobs/Vacancy...
Building in our prior work
pubmed.ncbi.nlm.nih.gov/39106867/
Reposted by Javier Gonzalez
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
August 1, 2025 at 3:01 PM
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Javier Gonzalez
This is, however, not clever or safe writing, it is a bad collective habit that needs to stop. Not by avoiding references to causality but by clear referencing to it
pubmed.ncbi.nlm.nih.gov/37286459/
pubmed.ncbi.nlm.nih.gov/37286459/
Guidelines for Reporting Observational Research in Urology: The Importance of Clear Reference to Causality - PubMed
Observational studies often dance around the issue of causality. We propose guidelines to ensure that papers refer to whether or not the study aim is to investigate causality, and suggest language to ...
pubmed.ncbi.nlm.nih.gov
July 31, 2025 at 8:33 AM
This is, however, not clever or safe writing, it is a bad collective habit that needs to stop. Not by avoiding references to causality but by clear referencing to it
pubmed.ncbi.nlm.nih.gov/37286459/
pubmed.ncbi.nlm.nih.gov/37286459/
The mixed-meal tolerance test in appetite research
🧵
Topics covered:
-Familiarisation/Standardisation 🟰
-Meal stimulus 🥣
-Appetite scales 😋
-Blood sampling 💉
-Blood analyses 🩸
-Data handling 📊
nature.com/articles/s41...
🧵
Topics covered:
-Familiarisation/Standardisation 🟰
-Meal stimulus 🥣
-Appetite scales 😋
-Blood sampling 💉
-Blood analyses 🩸
-Data handling 📊
nature.com/articles/s41...
July 31, 2025 at 10:52 AM
The mixed-meal tolerance test in appetite research
🧵
Topics covered:
-Familiarisation/Standardisation 🟰
-Meal stimulus 🥣
-Appetite scales 😋
-Blood sampling 💉
-Blood analyses 🩸
-Data handling 📊
nature.com/articles/s41...
🧵
Topics covered:
-Familiarisation/Standardisation 🟰
-Meal stimulus 🥣
-Appetite scales 😋
-Blood sampling 💉
-Blood analyses 🩸
-Data handling 📊
nature.com/articles/s41...
Reposted by Javier Gonzalez
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
OSF
osf.io
May 27, 2025 at 7:04 PM
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
Reposted by Javier Gonzalez
Here is a link to the trial I refer to. The energy expenditure outcome was one of several outcomes. Not all showed such unreliable response heterogeneity. The crucial estimand is the person-by-treatment interaction variance, not what is seen on a waterfall plot link.springer.com/article/10.1...
Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial - European Journal of Nutrition
Background Following consumption of a meal, circulating glucose concentrations can rise and then fall briefly below the basal/fasting concentrations. This phenomenon is known as reactive hypoglycaemia...
link.springer.com
March 12, 2025 at 7:38 AM
Here is a link to the trial I refer to. The energy expenditure outcome was one of several outcomes. Not all showed such unreliable response heterogeneity. The crucial estimand is the person-by-treatment interaction variance, not what is seen on a waterfall plot link.springer.com/article/10.1...
Reposted by Javier Gonzalez
No agreement at all. What we are dealing here is within-subjects (period-to-period) random variation swamping any response heterogeneity. Without a replicate trial, we wouldn't have known that 1st set of responses are not "true". Unfortunately, many conclusions on this topic are compromised by this.
March 12, 2025 at 7:38 AM
No agreement at all. What we are dealing here is within-subjects (period-to-period) random variation swamping any response heterogeneity. Without a replicate trial, we wouldn't have known that 1st set of responses are not "true". Unfortunately, many conclusions on this topic are compromised by this.
Reposted by Javier Gonzalez
Looks good doesn't it? This is how some researchers conclude there are individual differences in response. Some might even say participant 1 is an "extreme responder". But just to say that this trial was actually a replicate crossover. Here's the second set of differences plotted in the same order.
March 12, 2025 at 7:38 AM
Looks good doesn't it? This is how some researchers conclude there are individual differences in response. Some might even say participant 1 is an "extreme responder". But just to say that this trial was actually a replicate crossover. Here's the second set of differences plotted in the same order.
Reposted by Javier Gonzalez
Waterfall plots present changes or differences for individual cases. While "show the data" is 👍, just a reminder that these plots don't inform about treatment response heterogeneity on their own. Here's a plot of the treatment-control differences in energy expenditure from a crossover trial.
March 12, 2025 at 7:38 AM
Waterfall plots present changes or differences for individual cases. While "show the data" is 👍, just a reminder that these plots don't inform about treatment response heterogeneity on their own. Here's a plot of the treatment-control differences in energy expenditure from a crossover trial.
Reposted by Javier Gonzalez
New PhD opportunity in nutrition and metabolism at @uniofbath.bsky.social - closing date 31st March. Come and join CNEM! eur01.safelinks.protection.outlook.com?url=https%3A...
February 25, 2025 at 10:43 AM
New PhD opportunity in nutrition and metabolism at @uniofbath.bsky.social - closing date 31st March. Come and join CNEM! eur01.safelinks.protection.outlook.com?url=https%3A...