Ivy streeter
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ivystreeter.bsky.social
Ivy streeter
@ivystreeter.bsky.social
Developing CRISPR NGS off-target assays.
Interested in genomics, bioinformatics, and gene editing technologies.
https://ivystreeter.com/
Never thought I'd reach the point of writing R with Python packages. Nor did I ever think I'd write in light mode 🤔 🤨
September 21, 2025 at 2:17 AM
Reposted by Ivy streeter
Excited to share our paper in
@natimmunol.nature.com! Using in vivo #CRISPR screens we identify the E3 ligase STUB1 as a new cancer immunotherapy target in CD8 T cells. STUB1 is a dual function target: STUB1 KO promotes CD8 responses and STUB1 KO hinders tumor cells. www.nature.com/articles/s41...
A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity
Nature Immunology - LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as a potent negative regulator of CD8+...
rdcu.be
August 12, 2025 at 6:49 PM