IorioLab
@ioriolab.bsky.social
we mix informatics/biology/functional-genomics to identify new therapeutic targets/markers, for cancer and other human diseases. we ❤️ CRISPR, statistics and ML
The Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.
October 29, 2025 at 1:30 PM
The Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.
Kudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.
October 23, 2025 at 11:48 AM
Kudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.
Our very own Raffaele Iannuzzi successfully defended his PhD Thesis last week. Raf has worked on benchmarking CRISPRdata analytical tool and predictive models leveraging bulk & single cell RNA-seq data. We will definitely miss him. We wish him all the best as new adventures await! Congrats Raf! 🎉
October 22, 2025 at 7:23 AM
Our very own Raffaele Iannuzzi successfully defended his PhD Thesis last week. Raf has worked on benchmarking CRISPRdata analytical tool and predictive models leveraging bulk & single cell RNA-seq data. We will definitely miss him. We wish him all the best as new adventures await! Congrats Raf! 🎉
!!! Less than 2 weeks left to register !!! Join us in Milan for the 2nd European Cancer Dependency Map Symposium, taking place on 20 November 2025 at Human Technopole
Cancer functional genomics; CRISPR-based screening;
AIdriven targetDiscovery and drug development
humantechnopole.it/en/trainings...
Cancer functional genomics; CRISPR-based screening;
AIdriven targetDiscovery and drug development
humantechnopole.it/en/trainings...
October 21, 2025 at 10:08 AM
!!! Less than 2 weeks left to register !!! Join us in Milan for the 2nd European Cancer Dependency Map Symposium, taking place on 20 November 2025 at Human Technopole
Cancer functional genomics; CRISPR-based screening;
AIdriven targetDiscovery and drug development
humantechnopole.it/en/trainings...
Cancer functional genomics; CRISPR-based screening;
AIdriven targetDiscovery and drug development
humantechnopole.it/en/trainings...
Last week we had the pleasure of hosting @maxbillmann.bsky.social at @humantechnopole.bsky.social for an inspiring seminar on genetic interaction maps an networks. Fantastic to learn how CRISPR screens and integrative analyses can illuminate the logic of genetic dependencies. A big thank you Max 👏
October 21, 2025 at 8:57 AM
Last week we had the pleasure of hosting @maxbillmann.bsky.social at @humantechnopole.bsky.social for an inspiring seminar on genetic interaction maps an networks. Fantastic to learn how CRISPR screens and integrative analyses can illuminate the logic of genetic dependencies. A big thank you Max 👏
Kudos to Yasin Ilkagan Tepeli for defending his PhD at TU Delft (June 2025)! During his PhD at goncalveslab.tudelft.nl, he visited our lab working on Oncostratifier for oncogene-addicted cohort stratification and therapeutic target prediction.
Computational Molecular Biomedicine
in Computer Science Tecnical University of Lisbon
goncalveslab.tudelft.nl
October 10, 2025 at 7:47 AM
Kudos to Yasin Ilkagan Tepeli for defending his PhD at TU Delft (June 2025)! During his PhD at goncalveslab.tudelft.nl, he visited our lab working on Oncostratifier for oncogene-addicted cohort stratification and therapeutic target prediction.
Francesco will be speaking at the High-Content CRISPR Screening conference, taking place March 18–19, 2026 in Vienna 🇦🇹 alongside leading experts in CRISPR screening, functional genomics, and drug discovery
www.linkedin.com/posts/myllia...
www.linkedin.com/posts/myllia...
The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open!
Secure your spot via the conference website...
The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open!
Secure your spot via the conference website: https://...
www.linkedin.com
September 16, 2025 at 12:04 PM
Francesco will be speaking at the High-Content CRISPR Screening conference, taking place March 18–19, 2026 in Vienna 🇦🇹 alongside leading experts in CRISPR screening, functional genomics, and drug discovery
www.linkedin.com/posts/myllia...
www.linkedin.com/posts/myllia...
🚨 We’re hiring! 🚨 looking for a computational postdoc to lead an exciting project at the intersection of AI, CRISPR, multi-omics, and cancer genomics.
Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities
www.linkedin.com/jobs/view/42...
Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities
www.linkedin.com/jobs/view/42...
Human Technopole hiring Postdoc in Cancer Synthetic Lethality Prediction and AI-Driven Target Discovery in Milan, Lombardy, Italy | LinkedIn
Posted 2:37:53 PM. APPLICATION CLOSING DATE: October 12, 2025Human Technopole (HT) is an interdisciplinary life…See this and similar jobs on LinkedIn.
www.linkedin.com
September 11, 2025 at 4:30 PM
🚨 We’re hiring! 🚨 looking for a computational postdoc to lead an exciting project at the intersection of AI, CRISPR, multi-omics, and cancer genomics.
Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities
www.linkedin.com/jobs/view/42...
Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities
www.linkedin.com/jobs/view/42...
Today we bid farewell to our postDoc @aurorasavino.bsky.social, who is moving to an independent position at the University of Torino. Her talent dedication and collaborative spirit have left a lasting mark on our team and projects🎉
Wishing you all the best for this exciting next chapter, Aurora!
🥳🍾
Wishing you all the best for this exciting next chapter, Aurora!
🥳🍾
September 11, 2025 at 12:33 PM
Today we bid farewell to our postDoc @aurorasavino.bsky.social, who is moving to an independent position at the University of Torino. Her talent dedication and collaborative spirit have left a lasting mark on our team and projects🎉
Wishing you all the best for this exciting next chapter, Aurora!
🥳🍾
Wishing you all the best for this exciting next chapter, Aurora!
🥳🍾
Reposted by IorioLab
Just back from the GRC on Synthetic Lethality in Oncology: great science, deep discussion, great venue and flawless organisation. Thanks to @mgarnett.bsky.social, Benjamin Schwartz & @vazquezf.bsky.social for leading a fantastic meeting at the frontier of cancer research #SyntheticLethality #GRC
July 25, 2025 at 3:36 PM
Just back from the GRC on Synthetic Lethality in Oncology: great science, deep discussion, great venue and flawless organisation. Thanks to @mgarnett.bsky.social, Benjamin Schwartz & @vazquezf.bsky.social for leading a fantastic meeting at the frontier of cancer research #SyntheticLethality #GRC
Reposted by IorioLab
Enjoying the Gordon Conference on Synthetic Lethality in Oncology with @francescoiorio.bsky.social and @maxbillmann.bsky.social 😊 #bioinformatics #gordonConference #syntheticLethality
July 24, 2025 at 5:58 PM
Enjoying the Gordon Conference on Synthetic Lethality in Oncology with @francescoiorio.bsky.social and @maxbillmann.bsky.social 😊 #bioinformatics #gordonConference #syntheticLethality
Reposted by IorioLab
happy and honoured to have had a chance to deliver a lecture @bocconi.bsky.social University on AIapplications in life sciences and to share exciting projects we are developing at @humantechnopole.bsky.social-
A great opportunity to engage with a community that values innovation and forwardThinking
A great opportunity to engage with a community that values innovation and forwardThinking
July 18, 2025 at 6:16 PM
happy and honoured to have had a chance to deliver a lecture @bocconi.bsky.social University on AIapplications in life sciences and to share exciting projects we are developing at @humantechnopole.bsky.social-
A great opportunity to engage with a community that values innovation and forwardThinking
A great opportunity to engage with a community that values innovation and forwardThinking
New work out in @natgenet.nature.com from @davidjadams.bsky.social Lab @sangerinstitute.bsky.social (with a contribution from us led by A.Vinceti): CDS2 is a cancer dependency in uveal melanomas with low CDS1 expression: a synthetic lethal axis with broad potential
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types - Nature Genetics
This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic targe...
www.nature.com
July 6, 2025 at 3:14 PM
New work out in @natgenet.nature.com from @davidjadams.bsky.social Lab @sangerinstitute.bsky.social (with a contribution from us led by A.Vinceti): CDS2 is a cancer dependency in uveal melanomas with low CDS1 expression: a synthetic lethal axis with broad potential
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Reposted by IorioLab
Proud to announce that the 2nd European Cancer DepMap Symposium has the patronage of AIRC: the Italian Association for Cancer Research. Honoured by their support as we bring together leading scientists on cancer-dependencies functional-genomics CRISPR
🔗 humantechnopole.it/en/trainings...
#EuroDepMap
🔗 humantechnopole.it/en/trainings...
#EuroDepMap
June 19, 2025 at 11:40 AM
Proud to announce that the 2nd European Cancer DepMap Symposium has the patronage of AIRC: the Italian Association for Cancer Research. Honoured by their support as we bring together leading scientists on cancer-dependencies functional-genomics CRISPR
🔗 humantechnopole.it/en/trainings...
#EuroDepMap
🔗 humantechnopole.it/en/trainings...
#EuroDepMap
we are at #EACR2025 with two posters - the second one is presented by Ludovica Proietti and Gianluca vozza and focuses on our ERC funded DEPshock project
@humantechnopole.bsky.social
@humantechnopole.bsky.social
June 18, 2025 at 11:57 AM
we are at #EACR2025 with two posters - the second one is presented by Ludovica Proietti and Gianluca vozza and focuses on our ERC funded DEPshock project
@humantechnopole.bsky.social
@humantechnopole.bsky.social
we are at #EACR2025 with two posters, one presented by our Ottavio Croci on our collaborative work around a CRISPR based prioritisation of lncRNA vulnerabilities in multiple myeloma @humantechnopole.bsky.social
June 18, 2025 at 7:32 AM
we are at #EACR2025 with two posters, one presented by our Ottavio Croci on our collaborative work around a CRISPR based prioritisation of lncRNA vulnerabilities in multiple myeloma @humantechnopole.bsky.social
Reposted by IorioLab
Big thanks to @floriangrebien.bsky.social for a fantastic seminar yesterday at @humantechnopole.bsky.social 🔬🧬 a masterclass in dissecting AML vulnerabilities with precision and creativity. We loved the science and the lunch chat too! 👏 #cancerbiology #AML #condensates
June 12, 2025 at 7:38 PM
Big thanks to @floriangrebien.bsky.social for a fantastic seminar yesterday at @humantechnopole.bsky.social 🔬🧬 a masterclass in dissecting AML vulnerabilities with precision and creativity. We loved the science and the lunch chat too! 👏 #cancerbiology #AML #condensates
Big thanks to @floriangrebien.bsky.social for a fantastic seminar yesterday at @humantechnopole.bsky.social 🔬🧬 a masterclass in dissecting AML vulnerabilities with precision and creativity. We loved the science and the lunch chat too! 👏 #cancerbiology #AML #condensates
June 12, 2025 at 7:38 PM
Big thanks to @floriangrebien.bsky.social for a fantastic seminar yesterday at @humantechnopole.bsky.social 🔬🧬 a masterclass in dissecting AML vulnerabilities with precision and creativity. We loved the science and the lunch chat too! 👏 #cancerbiology #AML #condensates
🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR
🔬 Join us in Milan for the 2nd European Cancer Dependency Map Symposium #ECDM25! A key event for scientists in functional genomics & target discovery. Talks, panels, AI & poster sessions await.
Register now 👉 humantechnopole.it/en/trainings...
Register now 👉 humantechnopole.it/en/trainings...
June 11, 2025 at 3:02 PM
🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR
🎄🎁 Secret Santa at IorioLab! 🎁🎄
Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas
Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas
December 12, 2024 at 8:23 PM
🎄🎁 Secret Santa at IorioLab! 🎁🎄
Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas
Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas
Amazing Bavarian-style @humantechnopole.bsky.social CompBiol Centre Xmas Dinner w @bioimagecomputing.com @sottoriva.bsky.social and other labs 🍺🎄👍💻🧬
December 10, 2024 at 6:44 PM
Amazing Bavarian-style @humantechnopole.bsky.social CompBiol Centre Xmas Dinner w @bioimagecomputing.com @sottoriva.bsky.social and other labs 🍺🎄👍💻🧬
Reposted by IorioLab
Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social
Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning
Nature Communications - Multi-omics integration is often limited by data sparsity and heterogeneity. Here, the authors develop MOSA, a method designed to augment DepMap cell line data to...
rdcu.be
November 29, 2024 at 2:53 PM
Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social
🎓 Huge congratulations to Irene FernandezRebollo
and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social
and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social
November 28, 2024 at 9:44 PM
🎓 Huge congratulations to Irene FernandezRebollo
and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social
and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social
It has been great to be involved in this collaborative project linking ADD3 to cell morphology and vulnerabilities of glioblastoma, using data from the @depmap.org and computational analyses led by our Raffaele Iannuzzi @humantechnopole.bsky.social
🔬Our Kalebic group with our @francescoiorio.bsky.social Group identified ADD3 as a key gene driving glioblastoma stem cell shape and tumour connectivity, uncovering growth and therapy resistance
📰Published in Life Science Alliance with support from AIRC
humantechnopole.it/en/news/canc...
📰Published in Life Science Alliance with support from AIRC
humantechnopole.it/en/news/canc...
Cancer stem cell morphology predicts glioblastoma growth and resistance - Human Technopole
Human Technopole researchers have identified adducin-γ (ADD3) as a crucial regulator of glioblastoma cancer stem cell morphology and intercellular bridges between tumour cells. These connections facil...
humantechnopole.it
November 26, 2024 at 3:11 PM
It has been great to be involved in this collaborative project linking ADD3 to cell morphology and vulnerabilities of glioblastoma, using data from the @depmap.org and computational analyses led by our Raffaele Iannuzzi @humantechnopole.bsky.social
Reposted by IorioLab
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov