Innate2Adaptive research group @ UCL
@innate2adaptive.bsky.social
We aim to advance personalized/precision medicine for infections and cancer by improving diagnosis and patient stratification, and by driving innovations in vaccine design and immunotherapeutics.
Website: https://www.innate2adaptive.uk/
Website: https://www.innate2adaptive.uk/
Reposted by Innate2Adaptive research group @ UCL
Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1...
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.
T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal…
www.biorxiv.org
April 21, 2025 at 5:28 PM
Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1...
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
Reposted by Innate2Adaptive research group @ UCL
Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author
@maphemthembu.bsky.social
A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses
#HIVSky #IDSky #ImmunoSky
www.cell.com/iscience/ful...
@maphemthembu.bsky.social
A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses
#HIVSky #IDSky #ImmunoSky
www.cell.com/iscience/ful...
Dysfunctional bronchoalveolar effector memory CD8+ T cells in tuberculosis-exposed people living with antiretroviral-naïve HIV infection
Immunology; Virology
www.cell.com
December 5, 2024 at 1:32 PM
Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author
@maphemthembu.bsky.social
A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses
#HIVSky #IDSky #ImmunoSky
www.cell.com/iscience/ful...
@maphemthembu.bsky.social
A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses
#HIVSky #IDSky #ImmunoSky
www.cell.com/iscience/ful...
Reposted by Innate2Adaptive research group @ UCL
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications
It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...
www.nature.com
November 30, 2024 at 2:50 PM
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
Reposted by Innate2Adaptive research group @ UCL
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
November 21, 2024 at 10:30 AM
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Reposted by Innate2Adaptive research group @ UCL
Presented interesting paper in @innate2adaptive.bsky.social journal club today.
Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling:
- activated cells
- T cell-like monocytes & monocyte-like T cells
Unclear functional role & if 100% not artefact #Immunosky
Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling:
- activated cells
- T cell-like monocytes & monocyte-like T cells
Unclear functional role & if 100% not artefact #Immunosky
A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection
Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed a novel high-throughput method to study the transcriptome and adaptive immune re...
www.biorxiv.org
November 26, 2024 at 11:55 AM
Presented interesting paper in @innate2adaptive.bsky.social journal club today.
Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling:
- activated cells
- T cell-like monocytes & monocyte-like T cells
Unclear functional role & if 100% not artefact #Immunosky
Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling:
- activated cells
- T cell-like monocytes & monocyte-like T cells
Unclear functional role & if 100% not artefact #Immunosky
Reposted by Innate2Adaptive research group @ UCL
📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London.
.
🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position.
🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...
.
🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position.
🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
November 25, 2024 at 1:59 PM
📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London.
.
🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position.
🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...
.
🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position.
🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...
Reposted by Innate2Adaptive research group @ UCL
More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky
www.nature.com/artic...
#ImmunoSky
www.nature.com/artic...
Targeting immune–fibroblast cell communication in heart failure
Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...
www.nature.com
November 15, 2024 at 3:02 PM
More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky
www.nature.com/artic...
#ImmunoSky
www.nature.com/artic...