We’re thrilled to have Sumana and her group here at the WIMM, driving innovative research at the intersection of immunology and systems biology.

Ultimately, their goal is to engineer or reprogram T cell function to improve immune control in disease — enhancing function where needed and restraining it where necessary.

By combining experimental and computational strategies — including CRISPR-based perturbations, functional genomics, and network analysis — the Sharma Lab takes a systems-level approach to map how T cell states are established and transitioned.

Her team aims to define how signaling inputs are integrated to shape T cell behaviour across contexts such as cancer and viral infection. A particular focus is on inhibitory signaling networks in cytotoxic T cellsand how these pathways modulate cell state, effector function & adaptability.

Sumana’s group is dedicated to understanding how T cells are wired — from receptors and signaling pathways to transcriptional programs — and how these molecular circuits determine their function and state.

🎧 You can also listen to James’ radio interview from yesterday on BBC Sounds (starts around 26 minutes) — www.bbc.co.uk/sounds/play/...

🎥 Here’s an explanatory video — www.youtube.com/watch?v=EsI5...

And something a bit different — Abs recently featured on BBC Radio 4: www.bbc.co.uk/programmes/m...

Congratulations, Abs — we’re thrilled to see your new lab taking shape at the #MRCWIMM!

🧬 Recent work:
Check out this recent paper: www.ahajournals.org/doi/10.1161/...

Abs’ research is on building better human models to understand how & why blood and immune cells dysfunction in ageing & disease. His lab’s vision: by developing systems that more accurately capture real human biology, we can bridge the translational gap that has long stood between bench and bedside.

@medsci.ox.ac.uk @ox.ac.uk @oncology.ox.ac.uk

#BloodJournal #StemCellBiology #Hematopoiesis #CRISPR #StemCells #Genomics @bloodjournals.hematology.org @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk