MRC Weatherall Institute of Molecular Medicine
banner
imm.ox.ac.uk
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk
The MRC WIMM is a research institute at the University of Oxford with 5 core research areas: rare diseases, haematology, immunology and infection, stem cells and developmental biology and cancer biology.

www.imm.ox.ac.uk
Season's Greetings from all of us here at the MRC WIMM!

From molecules to twinkling light,
the WIMM is glowing bright tonight.
Happy holidays to all — we’re now signing out,
back on 2 January, refreshed throughout.
December 23, 2025 at 4:00 PM
#WIMMReads: A new #review in Nature Reviews Immunology by Hal Drakesmith and Joe N Frost explores how #iron shapes immune responses in infection inflammation and cancer.
Read more 👇

#Immunology #Immunology #IronMetabolism #Infection
@rdm.ox.ac.uk @drakesmith-lab.bsky.social @medsci.ox.ac.uk
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
www.nature.com
December 18, 2025 at 9:28 AM
We’re incredibly proud of our Sustainability Team for being recognised at the LEAF Oxford Forum yesterday.

#WIMMHighlights #WIMMCommunity #LEAFOxForum
@ox.ac.uk @medsci.ox.ac.uk
December 17, 2025 at 11:58 AM
#WIMMinFocus
Looks like a distant planet in deep space.
It is actually the edge of a cell #nucleus expanded in gel to reveal #chromatin in blue and sites of #DNA replication in red.

The Nuclear Sponge by George Lister
2025 WIMM Image Competition
#SciComm
@rdm.ox.ac.uk @medsci.ox.ac.uk
December 17, 2025 at 10:10 AM
#ScientistSpotlight
This week we’re introducing Anna Li, a postdoctoral researcher in the Yin Dong Lab at the #MRCWIMM.

@ndcnoxford.bsky.social @medsci.ox.ac.uk

#WIMMSpotlight #WIMMCommunity #StructuralBiology #CryoEM #IonChannels #Neuroscience

Photo credit: Susan Maxwell
December 16, 2025 at 9:54 AM
Great to be featured on the University of Oxford’s Pulse today. It’s fantastic to see this piece highlighting Hal Drakesmith and the Drakesmith Lab at the #MRCWIMM, working with colleagues from Oxford Earth Sciences.
www.ox.ac.uk/pulse/health... @ox.ac.uk
Tackling iron deficiency
More than 1.2 billion people worldwide are so iron-deficient that they develop iron-deficiency anaemia. The consequences include fatigue, dizziness, hair loss, greater risk of pregnancy complications,...
www.ox.ac.uk
December 15, 2025 at 4:08 PM
#WIMMReads: Led by Andrew Wilkie and Stephen Twigg, this study shows how optical genome mapping can help reveal the true structure of complex DNA duplications in genetic disease. 🧪

#Genomics #GeneticDiagnosis #StructuralVariants

@rdm.ox.ac.uk @medsci.ox.ac.uk
Exploring the size limits of Bionano optical genome mapping to resolve alternative structures of linked interspersed chromosomal duplications - Genome Medicine
Genome Medicine - Determining the correct structure of large, interspersed duplications and related complex genomic rearrangements in genetic disease is critical when establishing causal roles and...
link.springer.com
December 11, 2025 at 10:41 AM
#WIMMinFocus
This swirling scene shows fibrotic and non-fibrotic granuloma in sarcoidosis lung.

Each colour marks a cell type, revealing fibroblasts, pro fibrotic macrophages, CD four T cells and alveolar epithelium.

#SciComm @ndm.ox.ac.uk @medsci.ox.ac.uk
December 10, 2025 at 10:46 AM
Huge congratulations to Holly Russell who has been awarded a fellowship from the Lee Placito Medical Fund.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

www.imm.ox.ac.uk/news/holly-r...
Holly Russell receives Lee Placito Research Fellowship
Congratulations to Holly Russell who has been awarded a fellowship from the Lee Placito Medical Fund.
www.imm.ox.ac.uk
December 9, 2025 at 1:57 PM
#ScientistSpotlight
This week we’re featuring Naeema Mehmood, a #DPhil student in the De Bruijn Group at the MRC WIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk
December 9, 2025 at 9:48 AM
#WIMMReads The ISEH Junior Faculty Committee highlights why every PI can benefit from a Laboratory Handbook to support team culture, data practice & wellbeing.

With contribution from WIMM’s Professor Bethan Psaila, this resource reflects the WIMM commitment to supportive research environments.
👇
Building a transparent and functional laboratory culture: guidelines for creating a Laboratory Handbook for principal investigators
www.sciencedirect.com
December 4, 2025 at 9:49 AM
Final countdown to the MRC WIMM Festive Decoration Contest!
The judging panel had a very difficult decision to make…
Stay tuned to see who will take the festive crown!✨

youtu.be/BDOm1PUJe7s
Final Countdown!
YouTube video by MRC Weatherall Institute of Molecular Medicine
youtu.be
December 3, 2025 at 2:53 PM
#WIMMinFocus
May look like a dino egg swallowed a disco ball.
But it's actually an intestinal #organoid glowing in cyan, magenta and yellow to show #nuclei, E cadherin and Zonula Occludens one.

Disco Intestinal Organoid by Dimitrios Ioannidis
#SciArt runner up, 2025 #WIMMImageCompetition.

#SciComm
December 3, 2025 at 9:34 AM
#ScientistSpotlight

This week’s spotlight features Kexin Xu, a DPhil student in the Agne Antanaviciute Group at the MRC WIMM. Kexin is a biologist who taught herself machine learning and deep learning.

@rdm.ox.ac.uk @medsci.ox.ac.uk
December 2, 2025 at 10:12 AM
"It's beginning to look a lot like Gutmas!"

Congratulations to @vywien-lai.bsky.social on winning the MRF/MRC 2025 Festive Science Image Competition with these striking cross sections of gut tissue at different developmental stages 🧪🎄

@medresfdn.bsky.social @ukri.org @rdm.ox.ac.uk

Learn more 👇
It's beginning to look a lot like Gutmas!
Congratulations to Vy Wien Lai, whose image was chosen for 1st place in the MRC/MRF 2025 Festive Science Image Competition.
www.imm.ox.ac.uk
December 1, 2025 at 9:56 AM
#WIMMReads: A recent study from the Roy and Milne Groups shows that it’s not just #DNA mutations that make cancers behave differently.

In acute lymphoblastic leukemia (ALL), differences in how genes are switched on and off — through enhancers — help explain why each patient’s cancer is unique. 👇
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients
Key PointsDifferential enhancer activity contributes to oncogene overexpression and transcriptional diversity in primary KMT2A::AFF1 leukemia samples.Indiv
ashpublications.org
November 27, 2025 at 10:29 AM
#WIMMinFocus
These #megakaryocytes show six strange shapes as they respond to Galectin one. Their actin cytoskeleton is stained to reveal this variety.
Six of a Kind by Natalie Jooss
Honourable Mention, 2025 WIMM Image Competition.
#SciComm @rdm.ox.ac.uk @medsci.ox.ac.uk
November 26, 2025 at 1:25 PM
How much do you know about what’s going on in your gut? 🦠

That’s the question that a group of scientists, led by @anna-aulicino.bsky.social from the Simmons Group, asked attendees at ‘TECHWORKS’ - one of #IFOxford’s family zones this year.

Learn more 👇

@rdm.ox.ac.uk | @medsci.ox.ac.uk
Battle in the Gut at IF Oxford 2025
In October 2025, researchers from the MRC Translational Immune Discovery Unit led activities on researching gut bacteria at Oxford Science + Ideas Festival.
www.imm.ox.ac.uk
November 25, 2025 at 1:59 PM
#ScientistSpotlight
This week’s spotlight features Pei Rong Toh, a DPhil student in the Hal Drakesmith Group at the #MRCWIMM

@drakesmith-lab.bsky.social @medsci.ox.ac.uk @rdm.ox.ac.uk
November 25, 2025 at 9:45 AM
Reposted by MRC Weatherall Institute of Molecular Medicine
NEWS: Study reveals how drug resistance develops early in targeted AML therapy

A new study led by researchers at @rdm.ox.ac.uk has shown that resistance to a targeted treatment for acute myeloid leukaemia (AML) can develop much earlier than expected.
Study reveals how drug resistance develops early in targeted AML therapy
A new study led by researchers at the MRC Molecular Haematology Unit has shown that resistance to a targeted treatment for acute myeloid leukaemia (AML) can develop much earlier than expected.
www.medsci.ox.ac.uk
November 21, 2025 at 1:00 PM
#WIMMReads: Researchers from the MRC Molecular Haematology Unit and the MRC WIMM Centre for Computational Biology review how #DNA sequence shapes the complex regulatory layers inside our cells.
Read more 👇

#Genomics
#3DGenome
#ComputationalBiology
@rdm.ox.ac.uk @medsci.ox.ac.uk
The emerging sequence grammar of 3D genome organisation - Human Genetics
The multiplexed layers of regulatory processes and mechanisms within a cell are, to a degree, encoded in our genome. Unravelling the relationship between DNA sequence and molecular processes is crucia...
doi.org
November 20, 2025 at 9:38 AM
#WIMMinFocus
These shapes look like tiny sea creatures but they are healthy #platelets with bright pockets of #DNA in red. This image won the Eureka category of the 2025 WIMM Image Contest. Captured with a ZEISS LSM980 inverted confocal microscope with Airyscan detection.
#Microscopy #SciArt
November 19, 2025 at 3:01 PM
Oxford’s innovation is shaping a better future 🌍

From the world’s first high-efficacy malaria vaccine to breakthroughs in clean energy and neuro-inclusive design — Oxford research is driving real-world impact across every UN Sustainable Development Goal.

Read the 2025 Impact Report ⬇️
November 18, 2025 at 10:54 AM
#ScientistSpotlight: This week we’re introducing Verena Körber, one of the newest Group Leaders at the MRC WIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk
November 18, 2025 at 9:43 AM