David Sherman
@iamdsherman.bsky.social
Biochemist and cell biologist striving to improve human health | protein/lipid homeostasis | writer & consumer of fiction | science policy | views my own
Harvard Ph.D., Caltech / Amgen postdoc
Harvard Ph.D., Caltech / Amgen postdoc
Reposted by David Sherman
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I’m happy to share our latest paper on the function of PNPLA3-I148M, the most significant genetic risk factor for fatty liver disease (MASLD).
www.cell.com/cell-reports...
Many groups have tried to determine the function of PNPLA3 and its disease variant (I148M) since 2008...
Thread 🧵 1/5
www.cell.com/cell-reports...
Many groups have tried to determine the function of PNPLA3 and its disease variant (I148M) since 2008...
Thread 🧵 1/5
PNPLA3-I148M is a neomorph that interferes with two primary hepatic triglyceride clearance pathways
Sherman et al. show that the common fatty liver disease risk factor PNPLA3-I148M impairs
hepatic lipoprotein secretion by altering cellular membrane dynamics. This effect
is mediated by a protein that...
www.cell.com
October 7, 2025 at 4:31 AM
I’m happy to share our latest paper on the function of PNPLA3-I148M, the most significant genetic risk factor for fatty liver disease (MASLD).
www.cell.com/cell-reports...
Many groups have tried to determine the function of PNPLA3 and its disease variant (I148M) since 2008...
Thread 🧵 1/5
www.cell.com/cell-reports...
Many groups have tried to determine the function of PNPLA3 and its disease variant (I148M) since 2008...
Thread 🧵 1/5
Looking forward to engaging presentations and discussions at #ASBMB25! I’ll be by poster 270 (Abstract 2651) on Sunday highlighting some of our work on the biological function of the strongest known genetic risk factor for fatty liver disease worldwide, PNPLA3-I148M — stop by if you’re interested
April 10, 2025 at 9:02 PM
Looking forward to engaging presentations and discussions at #ASBMB25! I’ll be by poster 270 (Abstract 2651) on Sunday highlighting some of our work on the biological function of the strongest known genetic risk factor for fatty liver disease worldwide, PNPLA3-I148M — stop by if you’re interested
Reposted by David Sherman
Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
www.nature.com
March 26, 2025 at 5:48 PM
Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
Reposted by David Sherman
“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Opinion | Covid’s Deadliest Effect Took Five Years to Appear (Gift Article)
What once belonged to all of us now belongs to corporations.
www.nytimes.com
March 16, 2025 at 3:58 PM
“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Reposted by David Sherman
It's an honor to share this year's Passano Award with Ray Deshaies, Ph.D. for the development of PROTACs, a new therapeutic modality that targets proteins for degradation via co-opting the cellular protein recycling machinery.
March 11, 2025 at 11:49 AM
It's an honor to share this year's Passano Award with Ray Deshaies, Ph.D. for the development of PROTACs, a new therapeutic modality that targets proteins for degradation via co-opting the cellular protein recycling machinery.