Hyejung Won
@hyejungwon.bsky.social
Associate Professor at UNC Chapel Hill
Neurogenetics
wonlab.org
Neurogenetics
wonlab.org
Pinned
Hyejung Won
@hyejungwon.bsky.social
· Jan 27
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
High-throughput experimental validation of genetic variants linked to eight psychiatric
disorders reveals the regulatory mechanisms underlying variants with pleiotropic and
disorder-specific effects.
www.cell.com
1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Hyejung Won
Phenomenal talk from @hyejungwon.bsky.social who is visiting us @lieberinstitute.bsky.social for the day. Groundbreaking work w/ important implications and roadmap for using rapidly emerging information on psychiatric genetics to prioritize variants and understand their impact on 🧠 function
June 24, 2025 at 7:23 PM
Phenomenal talk from @hyejungwon.bsky.social who is visiting us @lieberinstitute.bsky.social for the day. Groundbreaking work w/ important implications and roadmap for using rapidly emerging information on psychiatric genetics to prioritize variants and understand their impact on 🧠 function
Reposted by Hyejung Won
Reposted by Hyejung Won
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
https://nature.com/articles/s4146…
May 27, 2025 at 8:33 AM
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
Reposted by Hyejung Won
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 16, 2025 at 4:39 PM
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Reposted by Hyejung Won
March 11, 2025 at 2:15 AM
Reposted by Hyejung Won
Very good new preprint by @nanamatoba.bsky.social @hyejungwon.bsky.social @steinlab.bsky.social, using a Massively Parallel Reporter Assay to gain insight into regulatory elements associated with inter-individual differences in cortical structure (Wnt response sensitivity plays a prominent role)🧪🧠🧬
Massively parallel assessment of gene regulatory activity at human cortical structure associated variants
Genetic association studies have identified hundreds of largely non-coding loci associated with inter-individual differences in the structure of the human cortex, though the specific genetic variants ...
www.biorxiv.org
February 12, 2025 at 9:44 AM
Very good new preprint by @nanamatoba.bsky.social @hyejungwon.bsky.social @steinlab.bsky.social, using a Massively Parallel Reporter Assay to gain insight into regulatory elements associated with inter-individual differences in cortical structure (Wnt response sensitivity plays a prominent role)🧪🧠🧬
1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
High-throughput experimental validation of genetic variants linked to eight psychiatric
disorders reveals the regulatory mechanisms underlying variants with pleiotropic and
disorder-specific effects.
www.cell.com
January 27, 2025 at 7:02 PM
1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Hyejung Won
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
@cellcellpress.bsky.social @hyejungwon.bsky.social
cell.com/cell/fulltex...
@cellcellpress.bsky.social @hyejungwon.bsky.social
cell.com/cell/fulltex...
January 22, 2025 at 8:51 PM
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
@cellcellpress.bsky.social @hyejungwon.bsky.social
cell.com/cell/fulltex...
@cellcellpress.bsky.social @hyejungwon.bsky.social
cell.com/cell/fulltex...
Reposted by Hyejung Won
Very elegant Massively Parallel Reporter Assay approach pursued by @hyejungwon.bsky.social & members of her group to reveal shared genetic variants of eight psychiatric disorders, out in Cell:
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
High-throughput experimental validation of genetic variants linked to eight psychiatric
disorders reveals the regulatory mechanisms underlying variants with pleiotropic and
disorder-specific effects.
www.cell.com
January 26, 2025 at 7:19 PM
Very elegant Massively Parallel Reporter Assay approach pursued by @hyejungwon.bsky.social & members of her group to reveal shared genetic variants of eight psychiatric disorders, out in Cell:
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Hyejung Won
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
November 25, 2024 at 6:37 PM
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr