Lara Hundsdorfer
@hundsdorfer.bsky.social
Interested in cell biomechanics &
host-pathogen interactions. Exploring how mechanical stretch impacts the behavior and infection of epithelial cell monolayers. PhD student in the Bastounis lab, University of Tübingen.
host-pathogen interactions. Exploring how mechanical stretch impacts the behavior and infection of epithelial cell monolayers. PhD student in the Bastounis lab, University of Tübingen.
Thanks for the amazing support @effiebastounis.bsky.social, the great contributions from all authors & collaborating labs (Serge Mostowy, María José Gómez Benito, Boris Macek, Tilman Schäffer, Iordania Constantinou) & for the support from @dfg.de, @cmfi.bsky.social & @unituebingen.bsky.social (4/4)
January 24, 2025 at 11:18 AM
Thanks for the amazing support @effiebastounis.bsky.social, the great contributions from all authors & collaborating labs (Serge Mostowy, María José Gómez Benito, Boris Macek, Tilman Schäffer, Iordania Constantinou) & for the support from @dfg.de, @cmfi.bsky.social & @unituebingen.bsky.social (4/4)
Collective infected cell extrusion (CICE) also occurs with another #pathogen & in vivo! Huge thanks to Marie Muenkel & the @sergemostowylab.bsky.social lab for showing that #zebrafish larvae fins infected with #Shigella also extrude the infected cells in an ERK activity dependent manner. (3/4)
January 24, 2025 at 11:18 AM
Collective infected cell extrusion (CICE) also occurs with another #pathogen & in vivo! Huge thanks to Marie Muenkel & the @sergemostowylab.bsky.social lab for showing that #zebrafish larvae fins infected with #Shigella also extrude the infected cells in an ERK activity dependent manner. (3/4)
Epithelial cells in monolayer ( #MDCK) coordinate their collective cell migration via ERK activation waves, thereby squeezing & extruding #host cells infected with #Listeria. ERK inhibition or constitutive activation abolish ERK activation waves and obstruct this cell extrusion. (2/4)
January 24, 2025 at 11:18 AM