Lara Hundsdorfer
@hundsdorfer.bsky.social
Interested in cell biomechanics &
host-pathogen interactions. Exploring how mechanical stretch impacts the behavior and infection of epithelial cell monolayers. PhD student in the Bastounis lab, University of Tübingen.
host-pathogen interactions. Exploring how mechanical stretch impacts the behavior and infection of epithelial cell monolayers. PhD student in the Bastounis lab, University of Tübingen.
Collective infected cell extrusion (CICE) also occurs with another #pathogen & in vivo! Huge thanks to Marie Muenkel & the @sergemostowylab.bsky.social lab for showing that #zebrafish larvae fins infected with #Shigella also extrude the infected cells in an ERK activity dependent manner. (3/4)
January 24, 2025 at 11:18 AM
Collective infected cell extrusion (CICE) also occurs with another #pathogen & in vivo! Huge thanks to Marie Muenkel & the @sergemostowylab.bsky.social lab for showing that #zebrafish larvae fins infected with #Shigella also extrude the infected cells in an ERK activity dependent manner. (3/4)
Epithelial cells in monolayer ( #MDCK) coordinate their collective cell migration via ERK activation waves, thereby squeezing & extruding #host cells infected with #Listeria. ERK inhibition or constitutive activation abolish ERK activation waves and obstruct this cell extrusion. (2/4)
January 24, 2025 at 11:18 AM