Hugo Brandao
@hugoresearch.bsky.social
biophysics, chromosomes, DNA
Reposted by Hugo Brandao
Today, we report a new discovery about this - a new twist to the story!
These SMC motor proteins do not only extrude the DNA into a loop. While doing so, they also put TWIST into the extruded DNA loop!
See our paper today in Science Advances: www.science.org/doi/10.1126/...
1/
These SMC motor proteins do not only extrude the DNA into a loop. While doing so, they also put TWIST into the extruded DNA loop!
See our paper today in Science Advances: www.science.org/doi/10.1126/...
1/
All eukaryotic SMC proteins induce a twist of −0.6 at each DNA loop extrusion step
Measuring single DNA loop extrusion steps of individual eukaryotic SMCs revealed that ATP binding induces a DNA twist of −0.6.
www.science.org
December 13, 2024 at 7:13 PM
Today, we report a new discovery about this - a new twist to the story!
These SMC motor proteins do not only extrude the DNA into a loop. While doing so, they also put TWIST into the extruded DNA loop!
See our paper today in Science Advances: www.science.org/doi/10.1126/...
1/
These SMC motor proteins do not only extrude the DNA into a loop. While doing so, they also put TWIST into the extruded DNA loop!
See our paper today in Science Advances: www.science.org/doi/10.1126/...
1/