Hugues Nury
@hugbum.bsky.social
Ion channels, structural biology. CNRS - Institut de Biologie Structurale - France. Current interests: protein design, biologics in crop protection.
Reposted by Hugues Nury
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
June 5, 2025 at 8:36 PM
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
The place where I work is hiring an expert in AI applied to the de novo design of proteins: urls.fr/DpLCMY
Excellent structural biology environment, amazing city surrounded by mountains.
Excellent structural biology environment, amazing city surrounded by mountains.
June 25, 2025 at 2:38 PM
The place where I work is hiring an expert in AI applied to the de novo design of proteins: urls.fr/DpLCMY
Excellent structural biology environment, amazing city surrounded by mountains.
Excellent structural biology environment, amazing city surrounded by mountains.
Reposted by Hugues Nury
New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A covalent recognition strategy enables conspecific mate identification
The olfactory system can detect an uncountable number of volatile molecules while retaining the ability to discriminate amongst very similar ones. We identified a unique mechanism employed by insect o...
www.biorxiv.org
June 3, 2025 at 9:59 PM
New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hugues Nury
Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc
Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions
Nature Communications - The association and dissociation dynamics of the ECF transporter complex for vitamin B12 are visualized by single-molecule FRET, highlighting the original transport...
rdcu.be
May 13, 2025 at 7:30 PM
Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc
🧪 Question for ion channels people: is it possible to use the membrane potential-sensitive FLIPR dyes in cytometry? Any protocol or reference to get started?
May 5, 2025 at 11:46 AM
🧪 Question for ion channels people: is it possible to use the membrane potential-sensitive FLIPR dyes in cytometry? Any protocol or reference to get started?
I used to love science fiction, and some books describing AI-governed worlds left a lasting impression on me (Ian M Banks, John Varley, ...). I enjoyed this short story about AI takeover, despite - or perhaps because of - its dead-serious academic tone.
ai-2027.com
ai-2027.com
AI 2027
A research-backed AI scenario forecast.
ai-2027.com
April 18, 2025 at 2:32 PM
I used to love science fiction, and some books describing AI-governed worlds left a lasting impression on me (Ian M Banks, John Varley, ...). I enjoyed this short story about AI takeover, despite - or perhaps because of - its dead-serious academic tone.
ai-2027.com
ai-2027.com
New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 27, 2025 at 7:51 AM
New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New preprint describing a primed nicotinic receptor state with only one agonist bound, seen at low [agonist]. My fav part: ~7% of particles are in that state on cryoEM grids... that's also the proportion predicted from the fitting of single-channel data! Work led by @mackthompson88.bsky.social
So happy to finally share my final paper from my PhD! By collecting cryo-EM datasets at sub-saturating concentrations of ACh, we were able to determine a mono-liganded state of the muscle-type nAChR. This state has a fully activated alpha subunit where ACh binds…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Asynchronous subunit transitions precede acetylcholine receptor activation
Rapid communication at synapses is facilitated by postsynaptic receptors, which convert a chemical signal into an electrical response. In the case of ligand-gated ion channels, agonist binding trigger...
www.biorxiv.org
December 3, 2024 at 7:28 PM
New preprint describing a primed nicotinic receptor state with only one agonist bound, seen at low [agonist]. My fav part: ~7% of particles are in that state on cryoEM grids... that's also the proportion predicted from the fitting of single-channel data! Work led by @mackthompson88.bsky.social
What examples would you include in a short lecture on transporters? My current ones are P4-ATPase and EAATs. Suggestions involving different techniques on top of multistate cryoEM particularly appreciated!
November 13, 2024 at 2:56 PM
What examples would you include in a short lecture on transporters? My current ones are P4-ATPase and EAATs. Suggestions involving different techniques on top of multistate cryoEM particularly appreciated!