Hugues Nury
@hugbum.bsky.social
Ion channels, structural biology. CNRS - Institut de Biologie Structurale - France. Current interests: protein design, biologics in crop protection.
Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!
March 27, 2025 at 7:51 AM
Our long term aim is to help develop environmentally benign insecticidal proteins. This mechanistic work is a first big milestone!
A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.
March 27, 2025 at 7:51 AM
A fungal-derived compound, ChroB, has an unanticipated mode-of-action (only two were known for GABAA targeting insecticides, since the 1950s) through a site that resembles the neurosteroid mammalian site. And nearby, a new PIP2 site.
Abamectin binds to the “classical” insecticide modulation site, where the bulk of resistant mutants are found. This -mectin bound structure is closed at the hydrophobic gate, unlike others.
March 27, 2025 at 7:51 AM
Abamectin binds to the “classical” insecticide modulation site, where the bulk of resistant mutants are found. This -mectin bound structure is closed at the hydrophobic gate, unlike others.
The GABA-bound receptor looks so much like human receptors at the site level. Many site mutations surprisingly cause spontaneous activation. The pore helices are weirdly arranged (look at Fig. 5)
March 27, 2025 at 7:51 AM
The GABA-bound receptor looks so much like human receptors at the site level. Many site mutations surprisingly cause spontaneous activation. The pore helices are weirdly arranged (look at Fig. 5)